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    TIC40 hydroxyproline-rich glycoprotein family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831524, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TIC40
    Official Full Name
    hydroxyproline-rich glycoprotein family protein
    Primary source
    TAIR:AT5G16620
    Locus tag
    AT5G16620
    See related
    Araport:AT5G16620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTIC40; MTG13.14; MTG13_14; PDE120; pigment defective embryo; pigment defective embryo 120; translocon at the inner envelope membrane of chloroplasts 40
    Summary
    chloroplast protein import (Tic40)
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    Genomic context

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    See TIC40 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (5450620..5454577)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA repair protein Rad4 family Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein import into chloroplasts via the Tic40-dependent and -independent pathways depends on the amino acid composition of the transit peptide. Lee DW, et al. Biochem Biophys Res Commun, 2019 Oct 8. PMID 31400859
    2. Reconstitution of protein targeting to the inner envelope membrane of chloroplasts. Li M, et al. J Cell Biol, 2006 Oct 23. PMID 17060496, Free PMC Article
    3. Solution structure of the C-terminal NP-repeat domain of Tic40, a co-chaperone during protein import into chloroplasts. Kao YF, et al. J Biochem, 2012 Nov. PMID 22888115
    4. Tic40 is important for reinsertion of proteins from the chloroplast stroma into the inner membrane. Chiu CC, et al. Plant J, 2008 Dec. PMID 18657235, Free PMC Article
    5. A novel serine/proline-rich domain in combination with a transmembrane domain is required for the insertion of AtTic40 into the inner envelope membrane of chloroplasts. Tripp J, et al. Plant J, 2007 Dec. PMID 17883373

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. protein can be imported into chloroplast by either Tic40-independent or Tic40-dependent pathways depending on the types of transit peptide.
      Title: Protein import into chloroplasts via the Tic40-dependent and -independent pathways depends on the amino acid composition of the transit peptide.
    2. Tic40 is a multifunctional protein that, in addition to its originally described role in protein import, is able to influence downstream processes leading to thylakoid biogenesis.
      Title: Suppressors of the Chloroplast Protein Import Mutant tic40 Reveal a Genetic Link between Protein Import and Thylakoid Biogenesis.
    3. Interaction of Tic40-NP and Hsp93 stimulates ATP hydrolysis of Hsp93, but the hydrolysis is abolished in both N320A and N329A mutants of Tic40-NP.
      Title: Solution structure of the C-terminal NP-repeat domain of Tic40, a co-chaperone during protein import into chloroplasts.
    4. In a Tic40 mutant soluble Tic40 and Tic110N intermediates accumulated in the chloroplast stroma due to a slower rate of reinsertion into the inner membrane.
      Title: Tic40 is important for reinsertion of proteins from the chloroplast stroma into the inner membrane.
    5. the sorting of AtTic40 requires a bipartite transit peptide, which is first cleaved by the stromal processing peptidase (SPP), thus generating a soluble AtTic40 stromal intermediate.
      Title: A novel serine/proline-rich domain in combination with a transmembrane domain is required for the insertion of AtTic40 into the inner envelope membrane of chloroplasts.
    6. analysis of similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein
      Title: Functional similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein (Hip).
    7. The interaction of Tic40 with rhomboid proteases in a yeast mitochondria-based assay is reported.
      Title: Uncovering a link between a plastid translocon component and rhomboid proteases using yeast mitochondria-based assays.
    8. The interaction of Tic110, Tic40 and Hsp93 in A. thaliana chloroplast protein transport is described. [AtTic40]
      Title: In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121668.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into chloroplast stroma IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Tic complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    hydroxyproline-rich glycoprotein family protein
    NP_197165.1
    • TIC40; INVOLVED IN: protein import into chloroplast stroma, chloroplast organization; LOCATED IN: in 6 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock chaperonin-binding (InterPro:IPR006636), 26S proteasome complex ubiquitin receptor, subunit Rpn13 (InterPro:IPR006773); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5450620..5454577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121668.4 → NP_197165.1  hydroxyproline-rich glycoprotein family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FMD5
      UniProtKB/TrEMBL
      A0A178UEV6, A0A5S9Y5J6
      Conserved Domains (2) summary
      pfam16550
      Location:299 → 345
      RPN13_C; UCH-binding domain
      pfam17830
      Location:386 → 438
      STI1; STI1 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FMD5.1

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