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    Eif4e3 eukaryotic translation initiation factor 4E member 3 [ Mus musculus (house mouse) ]

    Gene ID: 66892, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eif4e3provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E member 3provided by MGI
    Primary source
    MGI:MGI:1914142
    See related
    Ensembl:ENSMUSG00000093661 AllianceGenome:MGI:1914142
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    eIF4E-3; 1300018P11Rik
    Summary
    Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in blood vessel; central nervous system; and sensory organ. Orthologous to human EIF4E3 (eukaryotic translation initiation factor 4E family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 17.2), subcutaneous fat pad adult (RPKM 13.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif4e3 in Genome Data Viewer
    Location:
    6 D3; 6 45.98 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (99599008..99669834, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (99621879..99692873, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene forkhead box P1 Neighboring gene STARR-seq mESC enhancer starr_16824 Neighboring gene predicted gene, 52870 Neighboring gene STARR-positive B cell enhancer mm9_chr6:99211544-99211845 Neighboring gene STARR-positive B cell enhancer mm9_chr6:99214819-99215119 Neighboring gene STARR-positive B cell enhancer ABC_E4848 Neighboring gene STARR-seq mESC enhancer starr_16826 Neighboring gene STARR-positive B cell enhancer ABC_E6458 Neighboring gene STARR-positive B cell enhancer ABC_E4849 Neighboring gene STARR-positive B cell enhancer ABC_E6459 Neighboring gene STARR-seq mESC enhancer starr_16827 Neighboring gene predicted gene, 32882 Neighboring gene STARR-seq mESC enhancer starr_16828 Neighboring gene STARR-seq mESC enhancer starr_16829 Neighboring gene STARR-seq mESC enhancer starr_16831 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:99472882-99473069 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:99473114-99473223 Neighboring gene STARR-seq mESC enhancer starr_16834 Neighboring gene STARR-seq mESC enhancer starr_16835 Neighboring gene STARR-seq mESC enhancer starr_16836 Neighboring gene STARR-positive B cell enhancer mm9_chr6:99575045-99575346 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:99608680-99608863 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:99616004-99616187 Neighboring gene predicted gene, 52869 Neighboring gene G protein-coupled receptor 27 Neighboring gene predicted gene, 26748 Neighboring gene prokineticin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition. Osborne MJ, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23431134, Free PMC Article
    2. Characterization of mammalian eIF4E-family members. Joshi B, et al. Eur J Biochem, 2004 Jun. PMID 15153109
    3. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
    4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E type 3
    Names
    eIF-4E type 3
    eIF-4E3
    eIF4E type 3
    eukaryotic translation initiation factor-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025829.4 → NP_080105.1  eukaryotic translation initiation factor 4E type 3

      See identical proteins and their annotated locations for NP_080105.1

      Status: PROVISIONAL

      Source sequence(s)
      AC122929, AC152987
      Consensus CDS
      CCDS20386.1
      UniProtKB/Swiss-Prot
      Q9D983, Q9DBB5
      Related
      ENSMUSP00000032151.3, ENSMUST00000032151.3
      Conserved Domains (1) summary
      pfam01652
      Location:31 → 181
      IF4E; Eukaryotic initiation factor 4E

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      99599008..99669834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255550.2 → XP_030111410.1  eukaryotic translation initiation factor 4E type 3 isoform X1

      Conserved Domains (1) summary
      pfam01652
      Location:6 → 92
      IF4E; Eukaryotic initiation factor 4E

    2. XM_030255549.2 → XP_030111409.1  eukaryotic translation initiation factor 4E type 3 isoform X1

      Conserved Domains (1) summary
      pfam01652
      Location:6 → 92
      IF4E; Eukaryotic initiation factor 4E

    3. XM_036152264.1 → XP_036008157.1  eukaryotic translation initiation factor 4E type 3 isoform X1

      Conserved Domains (1) summary
      pfam01652
      Location:6 → 92
      IF4E; Eukaryotic initiation factor 4E

    4. XM_030255548.2 → XP_030111408.1  eukaryotic translation initiation factor 4E type 3 isoform X1

      Conserved Domains (1) summary
      pfam01652
      Location:6 → 92
      IF4E; Eukaryotic initiation factor 4E
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBB5.1 GenPept UniProtKB/Swiss-Prot:Q9DBB5

    Gene LinkOut

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