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    INHA inhibin subunit alpha [ Sus scrofa (pig) ]

    Gene ID: 397386, updated on 17-Aug-2024

    Summary

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    Official Symbol
    INHAprovided by VGNC
    Official Full Name
    inhibin subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:96372
    See related
    Ensembl:ENSSSCG00000020771
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Restricted expression toward ovary (RPKM 185.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See INHA in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 15 NC_010457.5 (121581847..121586020)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 15 NC_010457.4 (134507304..134511349, complement)

    Chromosome 15 - NC_010457.5Genomic Context describing neighboring genes Neighboring gene transmembrane protein 198 Neighboring gene obscurin like cytoskeletal adaptor 1 Neighboring gene UBX domain-containing protein 2B-like Neighboring gene serine/threonine kinase 11 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. circRNA-Mediated Inhibin-Activin Balance Regulation in Ovarian Granulosa Cell Apoptosis and Follicular Atresia. Ma M, et al. Int J Mol Sci, 2021 Aug 24. PMID 34502034, Free PMC Article
    2. Transcriptome sequencing analysis of porcine granulosa cells treated with an anti-inhibin antibody. Lei M, et al. Reprod Biol, 2017 Mar. PMID 28082104
    3. A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows. Li W, et al. J Vet Med Sci, 2016 May 18. PMID 26521695, Free PMC Article
    4. Association of inhibin-α gene polymorphisms with follicular cysts in large white sows. Li W, et al. Theriogenology, 2015 Oct 1. PMID 26208435
    5. SNPs in the porcine INHA gene and linkage mapping to SSC15. Hiendleder S, et al. Anim Genet, 2002 Jun. PMID 12030943

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. circRNA-Mediated Inhibin-Activin Balance Regulation in Ovarian Granulosa Cell Apoptosis and Follicular Atresia.
      Title: circRNA-Mediated Inhibin-Activin Balance Regulation in Ovarian Granulosa Cell Apoptosis and Follicular Atresia.
    2. Data suggest that, in granulosa cells, inhibin alpha-subunit is involved in regulation of cell proliferation, extracellular matrix remodeling, oogenesis, and ovulation. These studies were conducted in China and involved transcriptome sequencing analysis in cultured granulosa cells (from slaughterhouse pigs) exposed in vitro to a neutralizing anti-inhibin alpha-subunit antibody.
      Title: Transcriptome sequencing analysis of porcine granulosa cells treated with an anti-inhibin antibody.
    3. The relationship of INHA insertion/deletion polymorphisms with follicular cysts was investigated
      Title: A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows.
    4. This study provides evidence that the expressions of inhibin alpha subunit and betaglycan are inferior in cystic follicles, and this may be caused by the decrease in FSH in the presence of a cystic follicle.
      Title: Downregulation of the expression of inhibin α subunit and betaglycan in porcine cystic follicles.
    5. The c.-42G>A and c.3222G>A polymorphisms in the INHA gene are significantly associated with follicular cysts in sows.
      Title: Association of inhibin-α gene polymorphisms with follicular cysts in large white sows.
    6. INHA and INHB expression and cellular localization in porcine oocytes were studied.
      Title: Expression and cellular distribution of INHA and INHB before and after in vitro cultivation of porcine oocytes isolated from follicles of different size.
    7. inhibin alpha-subunits were localized in the granulosa cells of follicles at all stages but were not localized in corpora lutea.
      Title: Cellular Localization of Inhibin alpha-subunit, PKB/Akt and FoxO3a proteins in the ovaries of minipigs.
    8. Association of the INHA gene to ovulation rate.
      Title: Sequence variation and evaluation of inhibin alpha-subunit and steroidogenic acute regulatory protein for reproductive traits in swine.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibin alpha chain
    Names
    inhibin alpha subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214189.2 → NP_999354.1  inhibin alpha chain precursor

      See identical proteins and their annotated locations for NP_999354.1

      Status: PROVISIONAL

      Source sequence(s)
      X03265
      UniProtKB/Swiss-Prot
      P04087, Q2I0D4
      UniProtKB/TrEMBL
      A0A480NX98
      Related
      ENSSSCP00000021670.2, ENSSSCT00000031176.4
      Conserved Domains (1) summary
      smart00204
      Location:260 → 364
      TGFB; Transforming growth factor-beta (TGF-beta) family

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010457.5 Reference Sscrofa11.1 Primary Assembly

      Range
      121581847..121586020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021074693.1 → XP_020930352.1  inhibin alpha chain isoform X1

      Conserved Domains (1) summary
      smart00204
      Location:235 → 339
      TGFB; Transforming growth factor-beta (TGF-beta) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04087.2 GenPept UniProtKB/Swiss-Prot:P04087

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.