Foxj1 forkhead box J1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxj1provided by RGD
Official Full Name: forkhead box J1provided by RGD
Primary source: RGD:621764
See related: EnsemblRapid:ENSRNOG00000046001 AllianceGenome:RGD:621764
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hfh4; Hfh-4
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to insulin-like growth factor stimulus; response to estradiol; and spermatogenesis. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 43. Orthologous to human FOXJ1 (forkhead box J1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 72.9), Testes (RPKM 65.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (102065163..102069945, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (101566299..101570370, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (105282090..105289396, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and localization of FOXJ1 in S100beta-positive multiciliated cells of the rat pituitary has been described.
Title: Expression and localization of forkhead box protein FOXJ1 in S100β-positive multiciliated cells of the rat pituitary.
peripheral nerve crush-induced up-regulation of Foxj1 in the sciatic nerve was associated with Schwann cells proliferation.
Title: Changes in the Foxj1 expression of Schwann cells after sciatic nerve crush.
The findings of this study suggested that FOXJ1 plays an important role on neuronal production and neurogenesis in the adult brain after cerebral ischemia
Title: The expression of FOXJ1 in neurogenesis after transient focal cerebral ischemia.
Data suggest that Foxj1 may be involved in the pathophysiology of the brain after traumatic brain injury.
Title: Increased expression of Foxj1 after traumatic brain injury.
Data show that, although estradiol stimulates differentiation of epithelial cells, foxj1 but not estrogen receptor alpha is required for epithelial cell ciliogenesis of the neonatal oviduct.
Title: Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct.

Submit: New GeneRIF Correction

General gene information

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Markers

Foxj1 (e-PCR), detects polymorphism
- UniSTS:259328

RH135351 (e-PCR)
- UniSTS:218628

AU049465 (e-PCR)
- UniSTS:145912

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in axoneme assembly	IEA Inferred from Electronic Annotation more info
involved_in axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in axoneme assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin-like growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in central tolerance induction	IEA Inferred from Electronic Annotation more info
involved_in central tolerance induction	ISO Inferred from Sequence Orthology more info
involved_in ciliary basal body organization	IEA Inferred from Electronic Annotation more info
involved_in ciliary basal body organization	ISO Inferred from Sequence Orthology more info
involved_in ciliary basal body organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in determination of left/right symmetry	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelium development	ISO Inferred from Sequence Orthology more info
involved_in establishment of apical/basal cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of apical/basal cell polarity	ISO Inferred from Sequence Orthology more info
involved_in glomerular parietal epithelial cell development	IEA Inferred from Electronic Annotation more info
involved_in glomerular parietal epithelial cell development	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	IEA Inferred from Electronic Annotation more info
involved_in humoral immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within left/right pattern formation	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in lung epithelium development	IEA Inferred from Electronic Annotation more info
involved_in lung epithelium development	ISO Inferred from Sequence Orthology more info
involved_in metanephric part of ureteric bud development	IEA Inferred from Electronic Annotation more info
involved_in metanephric part of ureteric bud development	ISO Inferred from Sequence Orthology more info
involved_in motile cilium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of B cell activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of germinal center formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of germinal center formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of humoral immune response mediated by circulating immunoglobulin	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of central B cell tolerance induction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of central B cell tolerance induction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lung ciliated cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lung ciliated cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization	IEA Inferred from Electronic Annotation more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: forkhead box protein J1

Names: hepatocyte nuclear factor 3 forkhead homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053832.2 → NP_446284.2 forkhead box protein J1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q63247

UniProtKB/TrEMBL

A0A8I6GK97, A6HKW0

Related

ENSRNOP00000092642.1, ENSRNOT00000072687.4

Conserved Domains (1) summary

cd20023
Location:121 → 199

FH_FOXJ1; Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins