H2-Aa histocompatibility 2, class II antigen A, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-Aaprovided by MGI
Official Full Name: histocompatibility 2, class II antigen A, alphaprovided by MGI
Primary source: MGI:MGI:95895
See related: Ensembl:ENSMUSG00000036594 AllianceGenome:MGI:95895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha
Summary: Enables peptide antigen binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and positive regulation of T cell differentiation. Located in external side of plasma membrane and lysosome. Part of MHC class II protein complex. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); glomerulonephritis (multiple); hematologic cancer (multiple); and systemic scleroderma (multiple). Orthologous to human HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1) and HLA-DQA2 (major histocompatibility complex, class II, DQ alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 791.4), large intestine adult (RPKM 638.1) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34501718..34506797, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34282744..34287823, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate an alternative mechanism where lymph node stromal cells (LNSCs) tolerize CD4(+) T cells through the presentation of self-antigens via transferred peptide-MHCII complexes of dendritic cell origin.
Title: Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance.
Data show that MHC class II(+)Fas(+) BM cells were closely associated with CD4(+) T cells in the BM of affected animals.
Title: MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.
Analysis of CD8(+) T-cell-specific responses in A2xneu mice indicated that the priming activity of old A2xneu mice to induce an immune response was diminished compared with young animals.
Title: Implications of aging and self-tolerance on the generation of immune and antitumor immune responses.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H2-Aa (e-PCR), detects polymorphism
- UniSTS:238116

H2-Aa (e-PCR), detects polymorphism
- UniSTS:238117

H2-Aa (e-PCR), detects polymorphism
- UniSTS:143299

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of peptide antigen	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen assembly with MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class II protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histocompatibility 2, class II antigen A, alpha

Names: H-2 class II histocompatibility antigen, A-B alpha chain; H-2 class II histocompatibility antigen, A-F alpha chain; H-2 class II histocompatibility antigen, A-K alpha chain; H-2 class II histocompatibility antigen, A-Q alpha chain; H-2 class II histocompatibility antigen, A-R alpha chain; H-2 class II histocompatibility antigen, A-S alpha chain; H-2 class II histocompatibility antigen, A-U alpha chain; MHC class II antigen alpha chain; MHC-II I-A(d) alpha; histocompatibility 2, class II antigen A, alpha, promoter 1; major histocompatibility protein class II alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010378.3 → NP_034508.2 histocompatibility 2, class II antigen A, alpha precursor

See identical proteins and their annotated locations for NP_034508.2

Status: VALIDATED

Source sequence(s)

AK002532, BY604245, CR974422

Consensus CDS

CCDS28645.1

UniProtKB/Swiss-Prot

O78195, P01910, P14434

Related

ENSMUSP00000046105.7, ENSMUST00000040655.14

Conserved Domains (3) summary

cd05767
Location:113 → 206

IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00993
Location:31 → 109

MHC_II_alpha; Class II histocompatibility antigen, alpha domain

pfam16196
Location:204 → 255

C1-set_C; C1-set C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34501718..34506797 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P01910.2	GenPept	UniProtKB/Swiss-Prot:P01910
P04227.1	GenPept	UniProtKB/Swiss-Prot:P04227
P04228.1	GenPept	UniProtKB/Swiss-Prot:P04228
P14434.2	GenPept	UniProtKB/Swiss-Prot:P14434
P14435.1	GenPept	UniProtKB/Swiss-Prot:P14435
P14436.1	GenPept	UniProtKB/Swiss-Prot:P14436
P14437.1	GenPept	UniProtKB/Swiss-Prot:P14437
P14438.1	GenPept	UniProtKB/Swiss-Prot:P14438
P23150.1	GenPept	UniProtKB/Swiss-Prot:P23150