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    Stox2 storkhead box 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stox2provided by RGD
    Official Full Name
    storkhead box 2provided by RGD
    Primary source
    RGD:708477
    See related
    EnsemblRapid:ENSRNOG00000009590 AllianceGenome:RGD:708477
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryo development and maternal placenta development. Predicted to act upstream of or within response to bacterium. Predicted to be active in cytoplasm and nucleus. Orthologous to human STOX2 (storkhead box 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 61.4), Lung (RPKM 24.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stox2 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (51580855..51819909)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (44848179..45087238)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (47994555..48233588)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551690 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC120097575 Neighboring gene uncharacterized LOC103693959 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 6 Neighboring gene prothymosin alpha like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women: data from the Second Nord-Trondelag Health Study. Fenstad MH, et al. Mol Hum Reprod, 2010 Dec. PMID 20643876, Free PMC Article
    2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryo development ending in birth or egg hatching ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maternal placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maternal placenta development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    storkhead-box protein 2
    Names
    knockout CG10573-PA related
    spinelinin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134863.1 → NP_001128335.1  storkhead-box protein 2

      See identical proteins and their annotated locations for NP_001128335.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6G2M9, A6JPL7, D4A001
      Related
      ENSRNOP00000063517.1, ENSRNOT00000068562.4
      Conserved Domains (1) summary
      pfam10264
      Location:64 → 140
      Stork_head; Winged helix Storkhead-box1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      51580855..51819909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600114.3 → XP_017455603.1  storkhead-box protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTK2
      Related
      ENSRNOP00000082453.2, ENSRNOT00000117134.2
      Conserved Domains (1) summary
      pfam10264
      Location:131 → 209
      Stork_head; Winged helix Storkhead-box1 domain

    2. XM_017600116.3 → XP_017455605.1  storkhead-box protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTK2

    3. XM_017600118.3 → XP_017455607.1  storkhead-box protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G2M9
      Conserved Domains (1) summary
      pfam10264
      Location:1 → 79
      Stork_head; Winged helix Storkhead-box1 domain

    4. XM_039094522.2 → XP_038950450.1  storkhead-box protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G2M9
      Conserved Domains (1) summary
      pfam10264
      Location:1 → 79
      Stork_head; Winged helix Storkhead-box1 domain

    5. XM_039094520.2 → XP_038950448.2  storkhead-box protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G2M9
      Related
      ENSRNOP00000099583.1, ENSRNOT00000128483.1

    6. XM_039094521.2 → XP_038950449.1  storkhead-box protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G2M9
      Conserved Domains (1) summary
      pfam10264
      Location:12 → 90
      Stork_head; Winged helix Storkhead-box1 domain

    7. XM_006253152.5 → XP_006253214.1  storkhead-box protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K0Y3, A0A8I6G2M9
      Related
      ENSRNOP00000071628.2, ENSRNOT00000090839.3
      Conserved Domains (1) summary
      pfam10264
      Location:17 → 93
      Stork_head; Winged helix Storkhead-box1 domain

    8. XM_008771258.4 → XP_008769480.2  storkhead-box protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G2M9
      Conserved Domains (1) summary
      pfam10264
      Location:1 → 79
      Stork_head; Winged helix Storkhead-box1 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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