nhx-9 putative Na(+)/H(+) antiporter nhx-9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhx-9
Official Full Name: putative Na(+)/H(+) antiporter nhx-9
Primary source: WormBase:WBGene00003736
Locus tag: CELE_ZK822.3
See related: AllianceGenome:WB:WBGene00003736
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in excretory cell; intestine; and phasmid sensillum. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8 and end stage renal disease. Orthologous to human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhx-9 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 10

Sequence:: Chromosome: IV; NC_003282.8 (11930872..11935718)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

ZK822.3 (e-PCR)
- UniSTS:308306

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:proton antiporter activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	NAS Non-traceable Author Statement more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative Na(+)/H(+) antiporter nhx-9

NP_001023627.1

Confirmed by transcript evidence

NP_001023628.1

Confirmed by transcript evidence

NP_001379286.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11930872..11935718

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028457.6 → NP_001023628.1 putative Na(+)/H(+) antiporter nhx-9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023628.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P35449, Q95PV8, Q95PV9, Q95PW0

Conserved Domains (1) summary

pfam00999
Location:44 → 443

Na_H_Exchanger; Sodium/hydrogen exchanger family
NM_001028456.4 → NP_001023627.1 putative Na(+)/H(+) antiporter nhx-9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023627.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P35449

Conserved Domains (1) summary

pfam00999
Location:24 → 423

Na_H_Exchanger; Sodium/hydrogen exchanger family
NM_001392404.1 → NP_001379286.1 putative Na(+)/H(+) antiporter nhx-9 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

TIGR00840
Location:9 → 471

b_cpa1; sodium/hydrogen exchanger 3