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    idh-1 Isocitrate dehydrogenase [NADP] [ Caenorhabditis elegans ]

    Gene ID: 177775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    idh-1
    Official Full Name
    Isocitrate dehydrogenase [NADP]
    Primary source
    WormBase:WBGene00010317
    Locus tag
    CELE_F59B8.2
    See related
    AllianceGenome:WB:WBGene00010317
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in NADP metabolic process and isocitrate metabolic process. Predicted to be active in cytosol; mitochondrion; and peroxisome. Is expressed in several structures, including hypodermis; intestine; pharynx; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See idh-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (9439078..9441107, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Daxx;SPX domain-containing protein;Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NR LBD domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans. Yang HC, et al. J Mol Med (Berl), 2019 Mar. PMID 30661088, Free PMC Article
    2. In vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans. Vergano SS, et al. Mol Genet Metab, 2014 Mar. PMID 24445252, Free PMC Article
    3. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article
    4. C. elegans longevity pathways converge to decrease mitochondrial membrane potential. Lemire BD, et al. Mech Ageing Dev, 2009 Jul. PMID 19442682
    5. C. elegans ribosomal protein S3 protects against H(2)O(2)-induced DNA damage and suppresses spontaneous mutations in yeast. Elsakrmy N, et al. DNA Repair (Amst), 2022 Sep. PMID 35809390

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables isocitrate dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isocitrate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glyoxylate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isocitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isocitrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Isocitrate dehydrogenase [NADP]
    NP_001255392.1
    • Confirmed by transcript evidence
    NP_001255393.1
    • Confirmed by transcript evidence
    NP_001255394.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9439078..9441107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268463.4 → NP_001255392.1  Isocitrate dehydrogenase [NADP] [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2T4
      Conserved Domains (1) summary
      PTZ00435
      Location:27 → 432
      PTZ00435; isocitrate dehydrogenase; Provisional

    2. NM_001268464.3 → NP_001255393.1  Isocitrate dehydrogenase [NADP] [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255393.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21032
      Conserved Domains (1) summary
      PTZ00435
      Location:4 → 409
      PTZ00435; isocitrate dehydrogenase; Provisional

    3. NM_001268465.3 → NP_001255394.1  Isocitrate dehydrogenase [NADP] [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2T3
      Conserved Domains (1) summary
      cl00445
      Location:2 → 44
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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