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    fnta-1 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [ Caenorhabditis elegans ]

    Gene ID: 176840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fnta-1
    Official Full Name
    Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    Primary source
    WormBase:WBGene00019823
    Locus tag
    CELE_R02D3.5
    See related
    AllianceGenome:WB:WBGene00019823
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein farnesyltransferase activity. Predicted to be involved in peptide pheromone maturation. Predicted to be part of CAAX-protein geranylgeranyltransferase complex and protein farnesyltransferase complex. Predicted to be active in cytoplasm. Orthologous to human FNTA (farnesyltransferase, CAAX box, subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fnta-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (237591..240307, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BSD domain-containing protein Neighboring gene Protein asunder Neighboring gene Conserved oligomeric Golgi complex subunit 8 Neighboring gene Saccharopine dehydrogenase Neighboring gene Ground-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase. Hagemann A, et al. Front Chem, 2022. PMID 36561140, Free PMC Article
    2. Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans. Mörck C, et al. Proc Natl Acad Sci U S A, 2009 Oct 27. PMID 19826081, Free PMC Article
    3. Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs". Matthews LR, et al. Genome Res, 2001 Dec. PMID 11731503, Free PMC Article
    4. Intracellular lipid surveillance by small G protein geranylgeranylation. Watterson A, et al. Nature, 2022 May. PMID 35585236, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to CAAX-protein geranylgeranyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein farnesyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide pheromone maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein prenylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CAAX-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein farnesyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    NP_001380029.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      237591..240307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392242.1 → NP_001380029.1  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44501
      Conserved Domains (1) summary
      PLN02789
      Location:17 → 315
      PLN02789; farnesyltranstransferase
    Nucleotide Protein
    Heading Accession and Version

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