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    odr-4 Odorant response abnormal protein 4 [ Caenorhabditis elegans ]

    Gene ID: 175950, updated on 9-Dec-2024

    Summary

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    Official Symbol
    odr-4
    Official Full Name
    Odorant response abnormal protein 4
    Primary source
    WormBase:WBGene00003851
    Locus tag
    CELE_Y102E9.1
    See related
    AllianceGenome:WB:WBGene00003851
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in olfactory behavior; receptor localization to non-motile cilium; and response to odorant. Located in intracellular membrane-bounded organelle. Part of protein-containing complex. Is expressed in neurons. Orthologous to human ODR4 (odr-4 GPCR localization factor homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See odr-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (6730800..6733936)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Neighboring gene tRNA-Arg Neighboring gene Uncharacterized protein Neighboring gene HMA domain-containing protein Neighboring gene SEA domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sensory interaction between attractant diacetyl and repellent 2-nonanone in the nematode Caenorhabditis elegans. Matsuura T, et al. J Exp Zool A Ecol Genet Physiol, 2013 Jun. PMID 23580469
    2. Trafficking prerogatives of olfactory receptors. McClintock TS, et al. Neuroreport, 2003 Aug 26. PMID 14502073
    3. Neural circuit-dependent odor adaptation in C. elegans is regulated by the Ras-MAPK pathway. Hirotsu T, et al. Genes Cells, 2005 Jun. PMID 15938711
    4. Chemosensation: molecular mechanisms in worms and mammals. Prasad BC, et al. Trends Genet, 1999 Apr. PMID 10203825
    5. Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans. Rogers C, et al. Curr Biol, 2006 Apr 4. PMID 16581509

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ODR-4 also binds ODR-10, suggesting that an ODR-4/ODR-8 complex promotes GPCR folding, maturation, or export from the ER.
      Title: An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor localization to non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to odorant IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Odorant response abnormal protein 4
    NP_001022815.1
    • Confirmed by transcript evidence
    NP_001370710.1
    • Confirmed by transcript evidence
    NP_001379932.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6730800..6733936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392129.1 → NP_001379932.1  Odorant response abnormal protein 4 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61648, Q23233, Q8I7F7, Q8I7F8
      Conserved Domains (1) summary
      pfam14778
      Location:66 → 410
      ODR4-like; Olfactory receptor 4-like

    2. NM_001027644.9 → NP_001022815.1  Odorant response abnormal protein 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022815.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I7F8
      Conserved Domains (1) summary
      pfam14778
      Location:64 → 408
      ODR4-like; Olfactory receptor 4-like

    3. NM_001382900.2 → NP_001370710.1  Odorant response abnormal protein 4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam14778
      Location:34 → 380
      ODR4-like; Olfactory receptor 4-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I7F8.1

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