let-756 Protein let-756 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-756
Official Full Name: Protein let-756
Primary source: WormBase:WBGene00002881
Locus tag: CELE_C05D11.4
See related: AllianceGenome:WB:WBGene00002881
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; growth factor activity; and protein kinase binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; nematode larval development; and regulation of axon extension involved in axon guidance. Located in cytoplasm; extracellular space; and nuclear lumen. Is expressed in several structures, including body wall musculature; cephalic sensillum; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); brain disease (multiple); cognitive disorder (multiple); and urinary system cancer (multiple). Orthologous to several human genes including FGF3 (fibroblast growth factor 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See let-756 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (6407129..6410033)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the EFISIA motif in the core of LET-756 is essential for its biological activity
Title: Functional phylogeny relates LET-756 to fibroblast growth factor 9.
LET-756, like vertebrate FGF9, -16, and -20, belongs to the FGF9 family, whereas EGL-17, like vertebrate FGF8, -17, and -18, could be included in the FGF8 family [review]
Title: A pair as a minimum: the two fibroblast growth factors of the nematode Caenorhabditis elegans.
LET-756 exerts its functions through a balance between a synergy of several nuclear localization signals and attenuated secretion signal.
Title: Intracellular trafficking of LET-756, a fibroblast growth factor of C. elegans, is controlled by a balance of export and nuclear signals.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05D11.4 (e-PCR)
- UniSTS:313474

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein let-756

NP_498403.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6407129..6410033

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066002.7 → NP_498403.1 Protein let-756 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498403.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76831, Q11184

Conserved Domains (1) summary

smart00442
Location:70 → 209

FGF; Acidic and basic fibroblast growth factor family