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    alh-1 Aldehyde dehydrogenase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alh-1
    Official Full Name
    Aldehyde dehydrogenase domain-containing protein
    Primary source
    WormBase:WBGene00000107
    Locus tag
    CELE_F54D8.3
    See related
    AllianceGenome:WB:WBGene00000107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aldehyde dehydrogenase (NAD+) activity. Is expressed in head mesodermal cell; intestine; nervous system; pharynx; and rectal gland cell. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH1B1 (aldehyde dehydrogenase 1 family member B1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See alh-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5077764..5080661)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative tRNA-dihydrouridine synthase-like protein C45G9.2 Neighboring gene Uncharacterized protein Neighboring gene Inactive tau-tubulin kinase ttbk-6 Neighboring gene ncRNA Neighboring gene Cytochrome c oxidase subunit 6A, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved missense variant in ALDH1A3 ortholog impairs fecundity in C. elegans. Wong WR, et al. MicroPubl Biol, 2021 Jan 14. PMID 33474529, Free PMC Article
    2. Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-hydroxynonenal (4-HNE). Singh SP, et al. Aging (Albany NY), 2008 Dec 18. PMID 20157589, Free PMC Article
    3. Mass spectrometric proteome analysis suggests anaerobic shift in metabolism of Dauer larvae of Caenorhabditis elegans. Mádi A, et al. Biochim Biophys Acta, 2008 Nov. PMID 18620082
    4. iProteinDB: An Integrative Database of Drosophila Post-translational Modifications. Hu Y, et al. G3 (Bethesda), 2019 Jan 9. PMID 30397019, Free PMC Article
    5. Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. Kwon JY, et al. Genomics, 2004 Apr. PMID 15028283

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aldehyde dehydrogenase domain-containing protein
    NP_001379805.1
    • Confirmed by transcript evidence
    NP_498081.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5077764..5080661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392085.1 → NP_001379805.1  Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG19
      Conserved Domains (1) summary
      cd07091
      Location:1 → 415
      ALDH_F1-2_Ald2-like; ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins

    2. NM_065680.8 → NP_498081.2  Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498081.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20780
      Conserved Domains (1) summary
      cd07141
      Location:24 → 504
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    Nucleotide Protein
    Heading Accession and Version

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