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    vps-35 Vacuolar protein sorting-associated protein 35 [ Caenorhabditis elegans ]

    Gene ID: 174000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-35
    Official Full Name
    Vacuolar protein sorting-associated protein 35
    Primary source
    WormBase:WBGene00006933
    Locus tag
    CELE_F59G1.3
    See related
    AllianceGenome:WB:WBGene00006933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in positive regulation of protein localization to cell periphery; protein localization to postsynaptic membrane; and regulation of presynapse assembly. Located in cytosol; dendrite; and neuronal cell body. Is expressed in several structures, including body wall musculature; ciliated neurons; coelomocyte; intestine; and pharynx. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-35 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (5907816..5911219)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene LisH domain-containing protein;VQ domain-containing protein Neighboring gene TetraSPanin family Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Ceramide glucosyltransferase 3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. VPS35 and EIF4G1 interactions and novel candidate genes for PD: from genes to pathways and back. Erro R. Mov Disord, 2015 Apr. PMID 25771811
    2. BMP signaling requires retromer-dependent recycling of the type I receptor. Gleason RJ, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550286, Free PMC Article
    3. SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes. Norris A, et al. Proc Natl Acad Sci U S A, 2017 Jan 17. PMID 28053230, Free PMC Article
    4. Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein. Harterink M, et al. Development, 2011 Jul. PMID 21653614, Free PMC Article
    5. The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation. Vázquez-Manrique RP, et al. Genomics, 2007 Mar. PMID 17174523

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The retromer protein vps-35 is required in Wnt-expressing cells.
      Title: Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein localization to cell periphery IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynapse assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in dendrite IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer, cargo-selective complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vacuolar protein sorting-associated protein 35
    NP_495180.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5907816..5911219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062779.6 → NP_495180.2  Vacuolar protein sorting-associated protein 35 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495180.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1X3T7, Q21053
      Conserved Domains (1) summary
      pfam03635
      Location:14 → 771
      Vps35; Vacuolar protein sorting-associated protein 35
    Nucleotide Protein
    Heading Accession and Version

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