dhs-3 Protein dhs-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dhs-3
Official Full Name: Protein dhs-3
Primary source: WormBase:WBGene00000967
Locus tag: CELE_T02E1.5
See related: AllianceGenome:WB:WBGene00000967
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in response to oxidative stress. Located in lipid droplet. Is expressed in intestinal cell. Orthologous to human SDR16C5 (short chain dehydrogenase/reductase family 16C member 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dhs-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (8212362..8218324, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mechanism responsible for this negative regulation exerted by CD9 on LFA-1 adhesion does not involve changes in the affinity state of this integrin but seems to be related to alterations in its state of aggregation.
Title: Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans.
Data show that short-chain dehydrogenase, DHS-3 is almost exclusively localized on Lipid droplets (LDs), indicating that it can be used as a LD marker protein.
Title: Proteomic study and marker protein identification of Caenorhabditis elegans lipid droplets.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T02E1.4 (e-PCR)
- UniSTS:321032

T02E1.3 (e-PCR)
- UniSTS:317524

T02E1.5 (e-PCR)
- UniSTS:322287

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in response to oxidative stress	HEP more info	PubMed

Component	Evidence Code	Pubs
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein dhs-3

NP_001122508.1

Confirmed by transcript evidence

NP_001122509.1

Confirmed by transcript evidence

NP_001122510.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8212362..8218324 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001129036.4 → NP_001122508.1 Protein dhs-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122508.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5JYX5

Conserved Domains (2) summary

cd05339
Location:41 → 282

17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

pfam00106
Location:40 → 231

adh_short; short chain dehydrogenase
NM_001129037.4 → NP_001122509.1 Protein dhs-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122509.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5JYX4, A5JYX5, A5JYX6

Conserved Domains (1) summary

cd05339
Location:43 → 284

17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
NM_001129038.4 → NP_001122510.1 Protein dhs-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122510.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5JYX5

Conserved Domains (1) summary

cl21454
Location:3 → 143

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins