mtm-1 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase mtm-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mtm-1
Official Full Name: Phosphatidylinositol-3,5-bisphosphate 3-phosphatase mtm-1
Primary source: WormBase:WBGene00003475
Locus tag: CELE_Y110A7A.5
See related: AllianceGenome:WB:WBGene00003475
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in negative regulation of engulfment of apoptotic cell and phospholipid dephosphorylation. Located in apical cortex; cytosol; and plasma membrane. Is expressed in several structures, including coelomocyte; hermaphrodite somatic gonadal cell; neurons; pharynx; and vulva. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B1 and congenital structural myopathy. Orthologous to human MTM1 (myotubularin 1); MTMR1 (myotubularin related protein 1); and MTMR2 (myotubularin related protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mtm-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (5134739..5137971)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MTM-1, a PI 3-phosphatase that antagonizes the activities of PIKI-1 and VPS-34 by down-regulating phosphatidylinositol 3-phosphate on phagosomes.
Title: Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells.
Loss of mtm-1 function leads to substantially reduced numbers of persistent cell corpses in engulfment mutants, which is a result of a restoration of engulfment function rather than of impaired or delayed programmed cell death.
Title: The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.
Identified Caenorhabditis elegans myotubularin MTM-1 as a negative regulator of cell corpse engulfment. Show that loss of mtm-1 function accelerates the clearance of cell corpses by promoting their internalization.
Title: Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells.
at least three C. elegans MTMs play essential roles in coelomocyte endocytosis
Title: Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y110A7A.p (e-PCR)
- UniSTS:323451

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of engulfment of apoptotic cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Phosphatidylinositol-3,5-bisphosphate 3-phosphatase mtm-1

NP_491531.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5134739..5137971

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059130.6 → NP_491531.2 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase mtm-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491531.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N589

Conserved Domains (2) summary

cd13223
Location:36 → 141

PH-GRAM_MTM-like; Myotubularian 1 and related proteins Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase

pfam06602
Location:148 → 487

Myotub-related; Myotubularin-like phosphatase domain