Slc9a8 solute carrier family 9 member A8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc9a8provided by RGD
Official Full Name: solute carrier family 9 member A8provided by RGD
Primary source: RGD:1308193
See related: EnsemblRapid:ENSRNOG00000008354 AllianceGenome:RGD:1308193
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables sodium:proton antiporter activity. Involved in proton transmembrane transport; regulation of intracellular pH; and sodium ion transmembrane transport. Located in apical plasma membrane. Orthologous to human SLC9A8 (solute carrier family 9 member A8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 89.3), Adrenal (RPKM 83.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (176559658..176617510)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (156147855..156198497)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (164173045..164224747)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.
Title: Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.
NHE8 regulates Ca(2+) uptake into the proximal tubule epithelium.
Title: NHE8 attenuates Ca(2+) influx into NRK cells and the proximal tubule epithelium.
EGF inhibits intestinal NHE8 gene expression by reducing its basal transcription.
Title: Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.
Tumor necrosis factor-alpha downregulates intestinal NHE8 expression by reducing basal promoter activity.
Title: Tumor necrosis factor-{alpha} downregulates intestinal NHE8 expression by reducing basal promoter activity.
NHE8 is expressed along the gastrointestinal tract and NHE8 is a functional Na(+)/H(+) exchanger with kinetic characteristics that differ from other apically expressed NHE isoforms.
Title: Gastrointestinal distribution and kinetic characterization of the sodium-hydrogen exchanger isoform 8 (NHE8).
Thyroid hormone plays a potential role in the developmental isoform change from NHE8 to NHE3 and decreases NHE8 activity.
Title: Effect of thyroid hormone on the postnatal renal expression of NHE8.
NHE8 protein is expressed in the apical membrane of NRK cells as demonstrated by immunoblots, confocal fluorescent immunocytochemistry, and immunoelectron microscopy.
Title: Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells.
NHE-8 may play an important role in intestinal Na+ absorption during early life
Title: Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosome assembly	IEA Inferred from Electronic Annotation more info
involved_in acrosome assembly	ISO Inferred from Sequence Orthology more info
involved_in acrosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi lumen acidification	IEA Inferred from Electronic Annotation more info
involved_in regulation of Golgi lumen acidification	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sodium/hydrogen exchanger 8

Names: NHE-8; Na(+)/H(+) exchanger 8; solute carrier family 9 (sodium/hydrogen exchanger), member 8; solute carrier family 9 member 8; solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025281.2 → NP_001020452.2 sodium/hydrogen exchanger 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q4L208

UniProtKB/TrEMBL

A6JXJ7

Conserved Domains (1) summary

TIGR00840
Location:58 → 482

b_cpa1; sodium/hydrogen exchanger 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

176559658..176617510

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283885.1 → XP_063139955.1 sodium/hydrogen exchanger 8 isoform X1

UniProtKB/TrEMBL

A6JXJ7
XM_063283884.1 → XP_063139954.1 sodium/hydrogen exchanger 8 isoform X1

UniProtKB/TrEMBL

A6JXJ7
XM_017591797.3 → XP_017447286.1 sodium/hydrogen exchanger 8 isoform X2

UniProtKB/Swiss-Prot

Q4L208
XM_006235645.5 → XP_006235707.1 sodium/hydrogen exchanger 8 isoform X3

UniProtKB/Swiss-Prot

Q4L208

Conserved Domains (1) summary

cl01133
Location:54 → 431

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_063283887.1 → XP_063139957.1 sodium/hydrogen exchanger 8 isoform X5
XM_006235646.5 → XP_006235708.1 sodium/hydrogen exchanger 8 isoform X4

UniProtKB/Swiss-Prot

Q4L208

Related

ENSRNOP00000012175.4, ENSRNOT00000012175.6

Conserved Domains (1) summary

TIGR00840
Location:5 → 429

b_cpa1; sodium/hydrogen exchanger 3
XM_017591798.3 → XP_017447287.1 sodium/hydrogen exchanger 8 isoform X4

UniProtKB/Swiss-Prot

Q4L208

Conserved Domains (1) summary

TIGR00840
Location:5 → 429

b_cpa1; sodium/hydrogen exchanger 3
XM_039105140.1 → XP_038961068.1 sodium/hydrogen exchanger 8 isoform X4

UniProtKB/Swiss-Prot

Q4L208

Related

ENSRNOP00000102262.1, ENSRNOT00000171647.1

Conserved Domains (1) summary

TIGR00840
Location:5 → 429

b_cpa1; sodium/hydrogen exchanger 3
XM_039105141.1 → XP_038961069.1 sodium/hydrogen exchanger 8 isoform X6

Conserved Domains (1) summary

TIGR00840
Location:1 → 269

b_cpa1; sodium/hydrogen exchanger 3