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    Anapc15 anaphase promoting complex subunit 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Anapc15provided by RGD
    Official Full Name
    anaphase promoting complex subunit 15provided by RGD
    Primary source
    RGD:1311634
    See related
    EnsemblRapid:ENSRNOG00000019936 AllianceGenome:RGD:1311634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    APC15; RGD1311634
    Summary
    Predicted to be involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC15 (anaphase promoting complex subunit 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 142.8), Testes (RPKM 130.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Anapc15 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165650478..165678004)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156238640..156266005)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166981738..166985363)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene folate receptor beta Neighboring gene ribosomal protein L12, pseudogene 3 Neighboring gene folate receptor alpha Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein branched polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein branched polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein branched polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170435.1 → NP_001163906.1  anaphase-promoting complex subunit 15

      See identical proteins and their annotated locations for NP_001163906.1

      Status: VALIDATED

      Source sequence(s)
      FM103187, FM137052, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D3ZQX4, D4ACX3
      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Related
      ENSRNOP00000091579.1, ENSRNOT00000117670.2
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      165650478..165678004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106176.2 → XP_038962104.1  anaphase-promoting complex subunit 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZQX4, D4ACX3
      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    2. XM_063285205.1 → XP_063141275.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1

    3. XM_063285207.1 → XP_063141277.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1

    4. XM_039106196.2 → XP_038962124.1  anaphase-promoting complex subunit 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZQX4, D4ACX3
      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    5. XM_006229861.5 → XP_006229923.1  anaphase-promoting complex subunit 15 isoform X1

      See identical proteins and their annotated locations for XP_006229923.1

      UniProtKB/Swiss-Prot
      D3ZQX4, D4ACX3
      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    6. XM_063285202.1 → XP_063141272.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1

    7. XM_008759705.4 → XP_008757927.1  anaphase-promoting complex subunit 15 isoform X2

      See identical proteins and their annotated locations for XP_008757927.1

      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    8. XM_006229862.5 → XP_006229924.1  anaphase-promoting complex subunit 15 isoform X1

      See identical proteins and their annotated locations for XP_006229924.1

      UniProtKB/Swiss-Prot
      D3ZQX4, D4ACX3
      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    9. XM_039106208.2 → XP_038962136.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    10. XM_063285206.1 → XP_063141276.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1

    11. XM_006229869.5 → XP_006229931.1  anaphase-promoting complex subunit 15 isoform X2

      See identical proteins and their annotated locations for XP_006229931.1

      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    12. XM_017588966.3 → XP_017444455.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    13. XM_039106182.2 → XP_038962110.1  anaphase-promoting complex subunit 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZQX4, D4ACX3
      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    14. XM_017588962.3 → XP_017444451.1  anaphase-promoting complex subunit 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZQX4, D4ACX3
      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    15. XM_039106185.2 → XP_038962113.1  anaphase-promoting complex subunit 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZQX4, D4ACX3
      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    16. XM_006229860.4 → XP_006229922.1  anaphase-promoting complex subunit 15 isoform X1

      See identical proteins and their annotated locations for XP_006229922.1

      UniProtKB/Swiss-Prot
      D3ZQX4, D4ACX3
      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    17. XM_039106173.2 → XP_038962101.1  anaphase-promoting complex subunit 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZQX4, D4ACX3
      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:15 → 73
      ANAPC15; Anaphase-promoting complex subunit 15

    18. XM_039106204.1 → XP_038962132.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    19. XM_017588963.2 → XP_017444452.1  anaphase-promoting complex subunit 15 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYZ2, A6I6Y1
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZQX4.1 GenPept UniProtKB/Swiss-Prot:D3ZQX4

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