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    rnh1 ribonuclease H1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rnh1provided by FlyBase
    Official Full Name
    ribonuclease H1provided by FlyBase
    Primary source
    FLYBASE:FBgn0023171
    Locus tag
    Dmel_CG8729
    See related
    AllianceGenome:FB:FBgn0023171
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    74/9; CG8729; Dmel\CG8729; l(2)43F1-5; l(2)43Fa; l(2)k07409; l(2)k07624; RNase H1; RnH1; rnhl
    Summary
    Enables RNA-DNA hybrid ribonuclease activity. Involved in mitochondrial DNA replication. Located in mitochondrion and nucleus. Is expressed in brain; central nervous system; embryonic/larval proventriculus; gonad; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2. Orthologous to human RNASEH1 (ribonuclease H1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rnh1 in Genome Data Viewer
    Location:
    43F2-43F2; 2-57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7931054..7932380, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3818559..3819885, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lysine demethylase 4A Neighboring gene Major Facilitator Superfamily Transporter 12 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class X Neighboring gene drosha Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of RNase H1 from Drosophila melanogaster. Filippov V, et al. Biochem Biophys Res Commun, 1997 Nov 26. PMID 9398656
    2. R-loop Mapping and Characterization During Drosophila Embryogenesis Reveals Developmental Plasticity in R-loop Signatures. Munden A, et al. J Mol Biol, 2022 Jul 15. PMID 35609632, Free PMC Article
    3. Drosophila RNase H1 is essential for development but not for proliferation. Filippov V, et al. Mol Genet Genomics, 2001 Jul. PMID 11523794
    4. A second hybrid-binding domain modulates the activity of Drosophila ribonuclease H1. González de Cózar JM, et al. J Biochem, 2020 Nov 1. PMID 32589740, Free PMC Article
    5. Putative Drosophila odor receptor OR43b localizes to dendrites of olfactory neurons. Elmore T, et al. Insect Biochem Mol Biol, 2001 Jun 22. PMID 11378414

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. addition of FAT10 also led to an increased interaction between OTUB1 and its cognate E2 UbcH5B, implying a function of FAT10 in the inhibition of polyubiquitylation
      Title: RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA-DNA hybrid ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, removal of RNA primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonuclease H1
    Names
    CG8729-PA
    CG8729-PB
    RNaseH1
    rnh1-PA
    rnh1-PB
    NP_477315.1
    NP_995777.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7931054..7932380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206055.3 → NP_995777.1  ribonuclease H1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z768, O44114
      Conserved Domains (2) summary
      cd09280
      Location:164 → 307
      RNase_HI_eukaryote_like; Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts
      pfam01693
      Location:19 → 60
      Cauli_VI; Caulimovirus viroplasmin

    2. NM_057967.5 → NP_477315.1  ribonuclease H1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477315.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44114, Q7JY33
      Related
      FBpp0087959
      Conserved Domains (2) summary
      cd09280
      Location:183 → 326
      RNase_HI_eukaryote_like; Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts
      pfam01693
      Location:19 → 60
      Cauli_VI; Caulimovirus viroplasmin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z768 A1Z768
    O44114 O44114
    Q7JY33 Q7JY33

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