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    Rpt4R Regulatory particle triple-A ATPase 4-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39351, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpt4Rprovided by FlyBase
    Official Full Name
    Regulatory particle triple-A ATPase 4-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036224
    Locus tag
    Dmel_CG7257
    See related
    AllianceGenome:FB:FBgn0036224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    7257; CG7257; DmCG7257; Dmel\CG7257; Dm_Rpt4c
    Summary
    Predicted to enable proteasome-activating activity. Predicted to be involved in ERAD pathway; positive regulation of RNA polymerase II transcription preinitiation complex assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of cytosolic proteasome complex and proteasome regulatory particle, base subcomplex. Is expressed in organism. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpt4R in Genome Data Viewer
    Location:
    68E3-68E3; 3-37 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11941912..11943485)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11935012..11936585)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Succinate dehydrogenase, subunit A (flavoprotein)-like Neighboring gene brachyenteron Neighboring gene mir-285 stem loop Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Dnmt2-like protein mediates DNA methylation in Drosophila. Kunert N, et al. Development, 2003 Nov. PMID 12944428
    2. Evolution of proteasomal ATPases. Wollenberg K, et al. Mol Biol Evol, 2001 Jun. PMID 11371584
    3. Comparative Ubiquitome Analysis Reveals Deubiquitinating Effects Induced by Wolbachia Infection in Drosophila melanogaster. Zong Q, et al. Int J Mol Sci, 2022 Aug 21. PMID 36012723, Free PMC Article
    4. CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 33163493, Free PMC Article
    5. An AAA family tree. Fröhlich KU. J Cell Sci, 2001 May. PMID 11309190

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome-activating activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    regulatory particle triple-A ATPase 4-related
    Names
    CG7257-PA
    CG7257-PB
    Rpt4R-PA
    Rpt4R-PB
    NP_001287039.1
    NP_648525.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11941912..11943485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300110.1 → NP_001287039.1  regulatory particle triple-A ATPase 4-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287039.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTQ9
      Conserved Domains (2) summary
      COG1222
      Location:13 → 396
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
      pfam00004
      Location:180 → 312
      AAA; ATPase family associated with various cellular activities (AAA)

    2. NM_140268.2 → NP_648525.1  regulatory particle triple-A ATPase 4-related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTQ9
      Related
      FBpp0075772
      Conserved Domains (2) summary
      COG1222
      Location:13 → 396
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
      pfam00004
      Location:180 → 312
      AAA; ATPase family associated with various cellular activities (AAA)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTQ9 Q9VTQ9

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