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    CHRM1 cholinergic receptor muscarinic 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 483776, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CHRM1provided by VGNC
    Official Full Name
    cholinergic receptor muscarinic 1provided by VGNC
    Primary source
    VGNC:VGNC:39231
    See related
    Ensembl:ENSCAFG00845007309
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See CHRM1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (54835906..54849703)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (52389834..52403632)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (54299342..54313140)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (53933197..53947176)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (53507453..53521228)

    Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102157191 Neighboring gene solute carrier family 22 member 8 Neighboring gene solute carrier family 22 member 6 Neighboring gene uncharacterized LOC119864276 Neighboring gene solute carrier family 3 member 2 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caveolin 2 regulates endocytosis and trafficking of the M1 muscarinic receptor in MDCK epithelial cells. Shmuel M, et al. Mol Biol Cell, 2007 May. PMID 17314410, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. caveolins play a role in the attenuation of the M1 muscarinic receptor's intracellular trafficking to and from the plasma membrane
      Title: Caveolin 2 regulates endocytosis and trafficking of the M1 muscarinic receptor in MDCK epithelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G protein-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cognition IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of locomotion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in saliva secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    muscarinic acetylcholine receptor M1; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051822.1 Reference ROS_Cfam_1.0

      Range
      54835906..54849703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038425262.1 → XP_038281190.1  muscarinic acetylcholine receptor M1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MJA7, A0A8C0R0G3, A0A8I3RVA9
      Related
      ENSCAFP00845010054.1, ENSCAFT00845012901.1
      Conserved Domains (1) summary
      cd17790
      Location:26 → 429
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_038425263.1 → XP_038281191.1  muscarinic acetylcholine receptor M1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MJA7, A0A8C0R0G3, A0A8I3RVA9
      Related
      ENSCAFP00845010076.1, ENSCAFT00845012926.1
      Conserved Domains (1) summary
      cd17790
      Location:26 → 429
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049278.1 Alternate UMICH_Zoey_3.1

      Range
      53933197..53947176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038501531.1 → XP_038357459.1  muscarinic acetylcholine receptor M1 isoform X1

      Conserved Domains (1) summary
      cd17790
      Location:26 → 429
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_038501530.1 → XP_038357458.1  muscarinic acetylcholine receptor M1 isoform X2

      Conserved Domains (1) summary
      cd17790
      Location:246 → 649
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

      Range
      53507453..53521228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038628358.1 → XP_038484286.1  LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M1 isoform X1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

      Range
      54299342..54313140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038564218.1 → XP_038420146.1  muscarinic acetylcholine receptor M1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MJA7, A0A8C0R0G3, A0A8I3RVA9
      Conserved Domains (1) summary
      cd17790
      Location:26 → 429
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_038564217.1 → XP_038420145.1  muscarinic acetylcholine receptor M1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0T0L4, A0A8P0TT19
      Conserved Domains (1) summary
      cd17790
      Location:246 → 649
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      52389834..52403632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005631597.3 → XP_005631654.1  muscarinic acetylcholine receptor M1 isoform X1

      See identical proteins and their annotated locations for XP_005631654.1

      UniProtKB/TrEMBL
      A0A8C0MJA7, A0A8C0R0G3, A0A8I3RVA9
      Conserved Domains (1) summary
      cd17790
      Location:26 → 429
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_540897.6 → XP_540897.3  muscarinic acetylcholine receptor M1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0T0L4, A0A8P0TT19
      Conserved Domains (1) summary
      cd17790
      Location:246 → 649
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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