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    Pacsin2 protein kinase C and casein kinase substrate in neurons 2 [ Mus musculus (house mouse) ]

    Gene ID: 23970, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pacsin2provided by MGI
    Official Full Name
    protein kinase C and casein kinase substrate in neurons 2provided by MGI
    Primary source
    MGI:MGI:1345153
    See related
    Ensembl:ENSMUSG00000016664 AllianceGenome:MGI:1345153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SdpII
    Summary
    Enables cytoskeletal protein binding activity and lipid binding activity. Involved in cell projection morphogenesis; modulation of chemical synaptic transmission; and plasma membrane tubulation. Acts upstream of or within negative regulation of endocytosis. Located in caveola; cell-cell junction; and cytosol. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; aorta; cerebral cortex ventricular layer; genitourinary system; and thymus. Orthologous to human PACSIN2 (protein kinase C and casein kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 34.6), kidney adult (RPKM 33.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pacsin2 in Genome Data Viewer
    Location:
    15 E1; 15 39.4 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83259812..83348800, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83375607..83464610, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ARF GTPase activating protein 3 Neighboring gene RIKEN cDNA 1700001L05 gene Neighboring gene microRNA 12186 Neighboring gene predicted gene, 41368 Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2449 Neighboring gene predicted gene, 52181 Neighboring gene tubulin tyrosine ligase-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PACSIN proteins in vivo: Roles in development and physiology. Dumont V, et al. Acta Physiol (Oxf), 2022 Mar. PMID 34990060, Free PMC Article
    2. PACSIN2-dependent apical endocytosis regulates the morphology of epithelial microvilli. Postema MM, et al. Mol Biol Cell, 2019 Sep 1. PMID 31390291, Free PMC Article
    3. PACSIN2 regulates platelet integrin β1 hemostatic function. Biswas R, et al. J Thromb Haemost, 2023 Dec. PMID 37678551, Free PMC Article
    4. Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis. Hansen CG, et al. J Cell Sci, 2011 Aug 15. PMID 21807942
    5. Ultrastructural freeze-fracture immunolabeling identifies plasma membrane-localized syndapin II as a crucial factor in shaping caveolae. Koch D, et al. Histochem Cell Biol, 2012 Aug. PMID 22718246

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PACSIN2 regulates platelet integrin beta1 hemostatic function.
      Title: PACSIN2 regulates platelet integrin β1 hemostatic function.
    2. PACSIN proteins in vivo: Roles in development and physiology.
      Title: PACSIN proteins in vivo: Roles in development and physiology.
    3. Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes.
      Title: Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes.
    4. Pacsin 2 is necessary for cardiac development and function in mouse embryos.
      Title: Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.
    5. Pacsin 2 contributes to kidney development and repair in a nephron-specific manner.
      Title: The cytoplasmic protein Pacsin 2 in kidney development and injury repair.
    6. syndapin II binds to both flat and curved membranes in vivo and that it plays an important role in caveolar shaping, a role that it shares with PTRF/cavin 1.
      Title: Ultrastructural freeze-fracture immunolabeling identifies plasma membrane-localized syndapin II as a crucial factor in shaping caveolae.
    7. important role in the formation of plasma membrane caveolae
      Title: Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis.
    8. These findings suggest a novel function for PACSIN proteins 1, 2, and 3 in dynamic microtubule nucleation.
      Title: PACSIN proteins bind tubulin and promote microtubule assembly.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in caveola assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in caveola assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in caveolin-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in caveolin-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane tubulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C and casein kinase substrate in neurons protein 2
    Names
    Syndapin II
    syndapin-2
    syndapin-II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159509.2 → NP_001152981.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001152981.1

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Consensus CDS
      CCDS27701.1
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7
      Related
      ENSMUSP00000131504.2, ENSMUST00000171436.8
      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429 → 484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:348 → 428
      NPF; Rabosyn-5 repeating NPF sequence-motif

    2. NM_001159510.2 → NP_001152982.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001152982.1

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Consensus CDS
      CCDS27701.1
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7
      Related
      ENSMUSP00000155334.2, ENSMUST00000231184.2
      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429 → 484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:348 → 428
      NPF; Rabosyn-5 repeating NPF sequence-motif

    3. NM_001358641.2 → NP_001345570.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431 → 486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342 → 430
      NPF; Rabosyn-5 repeating NPF sequence-motif

    4. NM_001358642.2 → NP_001345571.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (2) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:390 → 445
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

    5. NM_001358643.2 → NP_001345572.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (2) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:388 → 443
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

    6. NM_001358644.2 → NP_001345573.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (2) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:390 → 445
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

    7. NM_001411850.1 → NP_001398779.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7

    8. NM_001411851.1 → NP_001398780.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7

    9. NM_001411852.1 → NP_001398781.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889

    10. NM_011862.4 → NP_035992.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      See identical proteins and their annotated locations for NP_035992.1

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Consensus CDS
      CCDS27701.1
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7
      Related
      ENSMUSP00000130098.2, ENSMUST00000165095.9
      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429 → 484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:348 → 428
      NPF; Rabosyn-5 repeating NPF sequence-motif

    RNA

    1. NR_177947.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      83259812..83348800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245633.4 → XP_011243935.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243935.1

      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431 → 486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342 → 430
      NPF; Rabosyn-5 repeating NPF sequence-motif

    2. XM_006520981.4 → XP_006521044.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521044.1

      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431 → 486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342 → 430
      NPF; Rabosyn-5 repeating NPF sequence-motif

    3. XM_036159409.1 → XP_036015302.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431 → 486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342 → 430
      NPF; Rabosyn-5 repeating NPF sequence-motif

    4. XM_006520980.4 → XP_006521043.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521043.1

      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431 → 486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342 → 430
      NPF; Rabosyn-5 repeating NPF sequence-motif

    5. XM_006520983.5 → XP_006521046.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521046.1

      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431 → 486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342 → 430
      NPF; Rabosyn-5 repeating NPF sequence-motif

    6. XM_006520982.2 → XP_006521045.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521045.1

      Conserved Domains (3) summary
      cd07679
      Location:18 → 275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431 → 486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342 → 430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVE8.1 GenPept UniProtKB/Swiss-Prot:Q9WVE8

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