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    HMBOX1 homeobox containing 1 [ Homo sapiens (human) ]

    Gene ID: 79618, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HMBOX1provided by HGNC
    Official Full Name
    homeobox containing 1provided by HGNC
    Primary source
    HGNC:HGNC:26137
    See related
    Ensembl:ENSG00000147421 MIM:618610; AllianceGenome:HGNC:26137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOT1; TAH1; PBHNF; HNF1LA
    Summary
    Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; telomere maintenance via telomerase; and telomere-telomerase complex assembly. Located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear body. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 3.8), testis (RPKM 3.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HMBOX1 in Genome Data Viewer
    Location:
    8p21.1-p12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (28890116..29053270)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (29168300..29331436)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28747912..28910787)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:28647439-28647939 Neighboring gene integrator complex subunit 9 Neighboring gene ribosomal protein L36a pseudogene 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19066 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:28728271-28728917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:28747269-28747825 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:28747826-28748382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27176 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:28834820-28835748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27177 Neighboring gene uncharacterized LOC105379346 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:28913988-28915187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27179 Neighboring gene Sharpr-MPRA regulatory region 8281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28924055-28924554 Neighboring gene RNA, 5S ribosomal pseudogene 260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28927814-28928543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28932443-28932946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28932947-28933448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28937642-28938205 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28945064-28945235 Neighboring gene kinesin family member 13B Neighboring gene MPRA-validated peak6973 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:29063474-29063627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27183 Neighboring gene high mobility group box 1 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19069 Neighboring gene uncharacterized LOC124901922 Neighboring gene Sharpr-MPRA regulatory region 4987 Neighboring gene uncharacterized LOC124901923

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanone attenuates LPS-induced inflammation and ROS production in EA.hy926 cells via HMBOX1 induction. Yuan HX, et al. J Cell Mol Med, 2019 Jan. PMID 30358079, Free PMC Article
    2. Homeobox‑containing protein 1 loss is associated with clinicopathological performance in glioma. Zhang P, et al. Mol Med Rep, 2017 Oct. PMID 28731165
    3. High-mobility group box-1 protein in tracheal aspirates from premature infants: relationship with bronchopulmonary dysplasia and steroid therapy. Aghai ZH, et al. J Perinatol, 2010 Sep. PMID 20182437
    4. Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening. Zhou S, et al. Oncol Rep, 2017 Jul. PMID 28628186
    5. Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis. Yu YL, et al. Biochem Biophys Res Commun, 2018 Jun 22. PMID 29709478

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High expression of HMBOX1 promotes the progression of lung squamous cell carcinoma.
      Title: High expression of HMBOX1 promotes the progression of lung squamous cell carcinoma.
    2. Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels.
      Title: Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels.
    3. TDD activates HMBOX1.
      Title: 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanone attenuates LPS-induced inflammation and ROS production in EA.hy926 cells via HMBOX1 induction.
    4. The association of HMBOX1 and CD133 with gastric neoplasm cell proliferation and migration are reported; the use of the levels of these proteins as prognostic markers are discussed.
      Title: High expression of HMBOX1 contributes to poor prognosis of gastric cancer by promoting cell proliferation and migration.
    5. HMBOX1 in hepatocytes acts as a key immunosuppressive factor for inflammation
      Title: HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation.
    6. this study demonstrates for the first time that c-Fos/miR-18a/HMBOX1 axis plays a critical role in the progression of gliomas
      Title: c-Fos/microRNA-18a feedback loop modulates the tumor growth via HMBOX1 in human gliomas.
    7. Low HMBOX1 expression is associated with liver cancer progression.
      Title: Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.
    8. HMBOX1 played important role in the high-grade serous ovarian cancer through regulation of proliferation and apoptosis.
      Title: Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis.
    9. HMBOX1 may be a potential diagnostic marker in glioma.
      Title: Homeobox‑containing protein 1 loss is associated with clinicopathological performance in glioma.
    10. Our data suggest a possible role of HMBOX1 in regulating radiosensitivity in cervical cancer cells.
      Title: Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21616

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables double-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables telomeric DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in telomere-telomerase complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in chromosome, telomeric region HDA PubMed 
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox-containing protein 1
    Names
    homeobox telomere-binding protein 1
    homeobox-containing protein PBHNF
    telomere-associated homeobox-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135726.3 → NP_001129198.1  homeobox-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001129198.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (1).
      Source sequence(s)
      AC108449, AK290683, BQ019252
      Consensus CDS
      CCDS6071.1
      UniProtKB/Swiss-Prot
      A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
      UniProtKB/TrEMBL
      E5RGZ2
      Related
      ENSP00000287701.10, ENST00000287701.15
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    2. NM_001324382.2 → NP_001311311.1  homeobox-containing protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (1).
      Source sequence(s)
      AC040975, AC108449, AK290683, BQ019252, DC358620, DC395744
      Consensus CDS
      CCDS6071.1
      UniProtKB/Swiss-Prot
      A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
      UniProtKB/TrEMBL
      E5RGZ2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    3. NM_001324383.2 → NP_001311312.1  homeobox-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108449, AK290683, AK295320, BC069242, BQ019252
      UniProtKB/TrEMBL
      E5RGZ2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    4. NM_001324384.1 → NP_001311313.1  homeobox-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108449, AK290683, AK295320, BC069242, BQ019252
      UniProtKB/TrEMBL
      E5RGZ2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    5. NM_001324385.2 → NP_001311314.1  homeobox-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC040975, AC091558, AC108449, AK290683, BQ019252
      UniProtKB/TrEMBL
      E5RGZ2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    6. NM_001324386.2 → NP_001311315.1  homeobox-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108449, AK290683, BQ019252, DQ153248
      UniProtKB/TrEMBL
      E5RGZ2
      Related
      ENSP00000430059.1, ENST00000519047.5
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    7. NM_001324387.2 → NP_001311316.1  homeobox-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC108449, AK290683, BQ019252, DQ153248
      UniProtKB/TrEMBL
      E5RGZ2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    8. NM_001324388.2 → NP_001311317.1  homeobox-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC040975, AC108449, AK290683, BQ019252, DC358620, DC395744, DQ153248
      UniProtKB/TrEMBL
      E5RGZ2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    9. NM_001324389.2 → NP_001311318.1  homeobox-containing protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC040975, AC091558, AC108449, AK290683, BQ019252
      UniProtKB/TrEMBL
      H0YLF2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    10. NM_001324390.1 → NP_001311319.1  homeobox-containing protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC091558, AC108449, BC069242, BQ019252
      UniProtKB/TrEMBL
      H0YLF2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    11. NM_001324391.2 → NP_001311320.1  homeobox-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC108449, AK290683, BC009259, BQ019252
      Consensus CDS
      CCDS83274.1
      UniProtKB/TrEMBL
      E5RGZ2
      Related
      ENSP00000453211.1, ENST00000558662.5
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    12. NM_001324392.1 → NP_001311321.1  homeobox-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC040975, AC091558, AC108449, BC069242, BQ019252
      Consensus CDS
      CCDS83274.1
      UniProtKB/TrEMBL
      E5RGZ2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    13. NM_001324393.2 → NP_001311322.1  homeobox-containing protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC108449, AK290683, BC009259, BQ019252, DC341559, DQ153248
      UniProtKB/TrEMBL
      H0YLF2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    14. NM_001324394.2 → NP_001311323.1  homeobox-containing protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC108449, AK290683, BC009259, BQ019252, DC341559, DQ153248
      UniProtKB/TrEMBL
      H0YLF2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    15. NM_001324395.2 → NP_001311324.1  homeobox-containing protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC108449, AK290683, BC009259, BQ019252
      UniProtKB/TrEMBL
      E5RGZ2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    16. NM_001330498.2 → NP_001317427.1  homeobox-containing protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC108449, BF369137, BQ019252, BX353564, HY077398
      Consensus CDS
      CCDS83273.1
      UniProtKB/TrEMBL
      E5RGZ2
      Related
      ENSP00000430110.1, ENST00000524238.3
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    17. NM_024567.4 → NP_078843.2  homeobox-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_078843.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 all encode the same isoform (1).
      Source sequence(s)
      AC108449, BC069242, BQ019252
      Consensus CDS
      CCDS6071.1
      UniProtKB/Swiss-Prot
      A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
      UniProtKB/TrEMBL
      E5RGZ2
      Related
      ENSP00000380516.3, ENST00000397358.7
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    RNA

    1. NR_136757.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108449, AK290683, BC009259, BQ019252

    2. NR_136758.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA400589, AC108449, AK290683, BQ019252, DQ153248

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      28890116..29053270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422223.1 → XP_047278179.1  homeobox-containing protein 1 isoform X4

      UniProtKB/Swiss-Prot
      A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
      UniProtKB/TrEMBL
      E5RGZ2

    2. XM_017013823.3 → XP_016869312.1  homeobox-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      E5RGZ2
      Conserved Domains (2) summary
      cd00086
      Location:268 → 340
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 227
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    3. XM_047422219.1 → XP_047278175.1  homeobox-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      E5RGZ2

    4. XM_047422224.1 → XP_047278180.1  homeobox-containing protein 1 isoform X4

      UniProtKB/Swiss-Prot
      A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
      UniProtKB/TrEMBL
      E5RGZ2

    5. XM_047422227.1 → XP_047278183.1  homeobox-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      E5RGZ2

    6. XM_006716398.3 → XP_006716461.1  homeobox-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      H0YLF2
      Related
      ENSP00000453185.1, ENST00000560599.5
      Conserved Domains (2) summary
      cd00086
      Location:268 → 305
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04814
      Location:25 → 226
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    7. XM_047422229.1 → XP_047278185.1  homeobox-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      H0YLF2

    8. XM_017013825.2 → XP_016869314.1  homeobox-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      H0YLF2
      Related
      ENSP00000430238.1, ENST00000521516.5
      Conserved Domains (1) summary
      pfam04814
      Location:25 → 226
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    9. XM_011544642.3 → XP_011542944.1  homeobox-containing protein 1 isoform X8

      Conserved Domains (1) summary
      pfam04814
      Location:25 → 226
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    10. XM_047422220.1 → XP_047278176.1  homeobox-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      E5RGZ2

    11. XM_047422222.1 → XP_047278178.1  homeobox-containing protein 1 isoform X4

      UniProtKB/Swiss-Prot
      A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
      UniProtKB/TrEMBL
      E5RGZ2

    12. XM_047422228.1 → XP_047278184.1  homeobox-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      E5RGZ2

    13. XM_047422221.1 → XP_047278177.1  homeobox-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      E5RGZ2

    14. XM_047422218.1 → XP_047278174.1  homeobox-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      E5RGZ2

    15. XM_047422226.1 → XP_047278182.1  homeobox-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      E5RGZ2
      Related
      ENSP00000475196.1, ENST00000355231.9

    RNA

    1. XR_001745595.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      29168300..29331436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361209.1 → XP_054217184.1  homeobox-containing protein 1 isoform X4

      UniProtKB/Swiss-Prot
      A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
      UniProtKB/TrEMBL
      E5RGZ2

    2. XM_054361203.1 → XP_054217178.1  homeobox-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      E5RGZ2

    3. XM_054361205.1 → XP_054217180.1  homeobox-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      E5RGZ2

    4. XM_054361210.1 → XP_054217185.1  homeobox-containing protein 1 isoform X4

      UniProtKB/Swiss-Prot
      A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
      UniProtKB/TrEMBL
      E5RGZ2

    5. XM_054361212.1 → XP_054217187.1  homeobox-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      E5RGZ2

    6. XM_054361214.1 → XP_054217189.1  homeobox-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      H0YLF2

    7. XM_054361216.1 → XP_054217191.1  homeobox-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      H0YLF2

    8. XM_054361215.1 → XP_054217190.1  homeobox-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      H0YLF2

    9. XM_054361217.1 → XP_054217192.1  homeobox-containing protein 1 isoform X8

    10. XM_054361206.1 → XP_054217181.1  homeobox-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      E5RGZ2

    11. XM_054361208.1 → XP_054217183.1  homeobox-containing protein 1 isoform X4

      UniProtKB/Swiss-Prot
      A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
      UniProtKB/TrEMBL
      E5RGZ2

    12. XM_054361213.1 → XP_054217188.1  homeobox-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      E5RGZ2

    13. XM_054361207.1 → XP_054217182.1  homeobox-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      E5RGZ2

    14. XM_054361204.1 → XP_054217179.1  homeobox-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      E5RGZ2

    15. XM_054361211.1 → XP_054217186.1  homeobox-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      E5RGZ2

    RNA

    1. XR_008487881.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NT76.1 GenPept UniProtKB/Swiss-Prot:Q6NT76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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