Akt3 AKT serine/threonine kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akt3provided by RGD
Official Full Name: AKT serine/threonine kinase 3provided by RGD
Primary source: RGD:62390
See related: EnsemblRapid:ENSRNOG00000021497 AllianceGenome:RGD:62390
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pkbg
Summary: Enables ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within cellular response to insulin stimulus and positive regulation of sodium ion transport. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 538.7), Thymus (RPKM 188.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q25

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (91475839..91758060, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (88943708..89225831, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (95076308..95348913, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RUNX1 targeting AKT3 promotes alveolar hypercoagulation and fibrinolytic inhibition in LPS induced ARDS.
Title: RUNX1 targeting AKT3 promotes alveolar hypercoagulation and fibrinolytic inhibition in LPS induced ARDS.
Bach1 modulates AKT3 transcription to participate in hyperglycaemia-mediated EndMT in vascular endothelial cells.
Title: Bach1 modulates AKT3 transcription to participate in hyperglycaemia-mediated EndMT in vascular endothelial cells.
MiR-22-3p and miR-29a-3p synergistically inhibit hepatic stellate cell activation by targeting AKT3.
Title: MiR-22-3p and miR-29a-3p synergistically inhibit hepatic stellate cell activation by targeting AKT3.
MiR-20b-5p modulates inflammation, apoptosis and angiogenesis in severe acute pancreatitis through autophagy by targeting AKT3.
Title: MiR-20b-5p modulates inflammation, apoptosis and angiogenesis in severe acute pancreatitis through autophagy by targeting AKT3.
Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures.
Title: Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures.
Rosmarinic acid inhibits DNA glycation and modulates the expression of Akt1 and Akt3 partially in the hippocampus of diabetic rats.
Title: Rosmarinic acid inhibits DNA glycation and modulates the expression of Akt1 and Akt3 partially in the hippocampus of diabetic rats.
The overexpressed miR-150 repressed the level of AKT3 and simultaneously alleviated mechanical and thermal hyperalgesia in a rat model of neuropathic pain.
Title: Effects of miR-150 on neuropathic pain process via targeting AKT3.
Suggest that when cardiomyocytes incur oxidative stress under diabetic conditions, it subsequently activates the PI3Kgamma/Akt cell-signaling pathway and further increases HMGB1 expression.
Title: Activation of PI3Kγ/Akt pathway increases cardiomyocyte HMGB1 expression in diabetic environment.
BAFF/BAFF-R involved in autoantibody production in rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.
Title: BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.
EGF but not insulin specifically upregulated Akt 2 and 3.
Title: Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132276 (e-PCR)
- UniSTS:215559

RH133674 (e-PCR)
- UniSTS:216957

AI413057 (e-PCR)
- UniSTS:261296

BI301874 (e-PCR)
- UniSTS:247002

RH128880 (e-PCR)
- UniSTS:212188

RH134046 (e-PCR)
- UniSTS:217328

BF416653 (e-PCR)
- UniSTS:249330

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in brain morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial genome maintenance	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial genome maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of PERK-mediated unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell size	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: RAC-gamma serine/threonine-protein kinase

Names: AKT3 kinase; PKB gamma; RAC-PK-gamma; protein kinase Akt-3; protein kinase B, gamma; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

NP_113763.2

EC 2.7.11.1

XP_038946556.1

EC 2.7.11.1

XP_038946557.1

EC 2.7.11.1

XP_038946558.1

EC 2.7.11.1

XP_038946559.1

EC 2.7.11.1

XP_038946560.1

EC 2.7.11.1

XP_038946561.1

EC 2.7.11.1

XP_038946562.1

EC 2.7.11.1

XP_038946563.1

EC 2.7.11.1

XP_038946564.1

EC 2.7.11.1

XP_038946565.1

EC 2.7.11.1

XP_063128274.1

EC 2.7.11.1

XP_063128275.1

EC 2.7.11.1

XP_063128276.1

EC 2.7.11.1

XP_063128277.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429654.1 → NP_001416583.1 RAC-gamma serine/threonine-protein kinase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q63484

UniProtKB/TrEMBL

A0A0G2JXD7
NM_001429655.1 → NP_001416584.1 RAC-gamma serine/threonine-protein kinase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q63484

UniProtKB/TrEMBL

A0A0G2JXD7
NM_031575.2 → NP_113763.2 RAC-gamma serine/threonine-protein kinase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q63484

UniProtKB/TrEMBL

A0A0G2JXD7

Related

ENSRNOP00000070231.3, ENSRNOT00000085648.3

Conserved Domains (2) summary

cd01241
Location:4 → 110

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05593
Location:132 → 479

STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

91475839..91758060 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090632.2 → XP_038946560.1 RAC-gamma serine/threonine-protein kinase isoform X4

UniProtKB/TrEMBL

A6JGD0

Conserved Domains (2) summary

cd01241
Location:4 → 110

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cl21453
Location:152 → 419

PKc_like; Protein Kinases, catalytic domain
XM_039090633.2 → XP_038946561.1 RAC-gamma serine/threonine-protein kinase isoform X5

Conserved Domains (2) summary

cd01241
Location:4 → 110

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05593
Location:132 → 479

STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
XM_039090628.2 → XP_038946556.1 RAC-gamma serine/threonine-protein kinase isoform X1

UniProtKB/TrEMBL

A6JGD0

Conserved Domains (2) summary

cd01241
Location:4 → 133

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cl21453
Location:175 → 442

PKc_like; Protein Kinases, catalytic domain
XM_039090631.2 → XP_038946559.1 RAC-gamma serine/threonine-protein kinase isoform X3

UniProtKB/TrEMBL

F1M6A8

Related

ENSRNOP00000054688.6, ENSRNOT00000057879.6

Conserved Domains (2) summary

cd01241
Location:4 → 133

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05571
Location:175 → 474

STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B
XM_039090630.2 → XP_038946558.1 RAC-gamma serine/threonine-protein kinase isoform X2

UniProtKB/Swiss-Prot

Q63484

Conserved Domains (2) summary

cd01241
Location:4 → 133

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05593
Location:155 → 502

STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
XM_063272204.1 → XP_063128274.1 RAC-gamma serine/threonine-protein kinase isoform X5
XM_039090629.2 → XP_038946557.1 RAC-gamma serine/threonine-protein kinase isoform X1

UniProtKB/TrEMBL

A6JGD0

Conserved Domains (2) summary

cd01241
Location:4 → 133

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cl21453
Location:175 → 442

PKc_like; Protein Kinases, catalytic domain
XM_039090637.2 → XP_038946565.1 RAC-gamma serine/threonine-protein kinase isoform X8

UniProtKB/TrEMBL

A6JGD0

Conserved Domains (2) summary

cl17171
Location:1 → 49

PH-like; Pleckstrin homology-like domain

cl21453
Location:91 → 358

PKc_like; Protein Kinases, catalytic domain
XM_063272205.1 → XP_063128275.1 RAC-gamma serine/threonine-protein kinase isoform X8

UniProtKB/TrEMBL

A6JGD0
XM_039090634.2 → XP_038946562.1 RAC-gamma serine/threonine-protein kinase isoform X6

UniProtKB/TrEMBL

A6JGD0

Conserved Domains (2) summary

cd01241
Location:7 → 105

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cl21453
Location:147 → 414

PKc_like; Protein Kinases, catalytic domain
XM_063272206.1 → XP_063128276.1 RAC-gamma serine/threonine-protein kinase isoform X8

UniProtKB/TrEMBL

A6JGD0
XM_039090635.1 → XP_038946563.1 RAC-gamma serine/threonine-protein kinase isoform X7

UniProtKB/TrEMBL

A6JGD0

Related

ENSRNOP00000106081.1, ENSRNOT00000136405.1

Conserved Domains (2) summary

cl17171
Location:18 → 71

PH-like; Pleckstrin homology-like domain

cl21453
Location:113 → 380

PKc_like; Protein Kinases, catalytic domain
XM_063272207.1 → XP_063128277.1 RAC-gamma serine/threonine-protein kinase isoform X10
XM_039090636.2 → XP_038946564.1 RAC-gamma serine/threonine-protein kinase isoform X9

Conserved Domains (2) summary

cd01241
Location:4 → 133

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cl21453
Location:175 → 339

PKc_like; Protein Kinases, catalytic domain