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    LILRB1 leukocyte immunoglobulin like receptor B1 [ Homo sapiens (human) ]

    Gene ID: 10859, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LILRB1provided by HGNC
    Official Full Name
    leukocyte immunoglobulin like receptor B1provided by HGNC
    Primary source
    HGNC:HGNC:6605
    See related
    Ensembl:ENSG00000104972 MIM:604811; AllianceGenome:HGNC:6605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B
    Summary
    This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in appendix (RPKM 25.9), spleen (RPKM 20.5) and 10 other tissues See more
    Orthologs
    all
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    Genomic context

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    See LILRB1 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54616322..54638022)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57709827..57731530)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55127776..55149473)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor A2 Neighboring gene leukocyte immunoglobulin like receptor A1 Neighboring gene microRNA 8061 Neighboring gene vomeronasal 1 receptor 105 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Association of atherosclerosis with expression of the LILRB1 receptor by human NK and T-cells supports the infectious burden hypothesis. Romo N, et al. Arterioscler Thromb Vasc Biol, 2011 Oct. PMID 21817101
    2. HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j. Morel E, et al. J Immunol, 2008 Aug 15. PMID 18684926
    3. Expression of the CD85j (leukocyte Ig-like receptor 1, Ig-like transcript 2) receptor for class I major histocompatibility complex molecules in idiopathic inflammatory myopathies. Schleinitz N, et al. Arthritis Rheum, 2008 Oct. PMID 18821690
    4. SP1-induced lncRNA TINCR overexpression contributes to colorectal cancer progression by sponging miR-7-5p. Yu S, et al. Aging (Albany NY), 2019 Mar 10. PMID 30853664, Free PMC Article
    5. hsa-miR-7 Is a Potential Biomarker for Idiopathic Inflammatory Myopathies with Interstitial Lung Disease in Humans. Yu L, et al. Ann Clin Lab Sci, 2018 Nov. PMID 30610047

    See all (170) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis.
      Title: LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis.
    2. Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis.
      Title: Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis.
    3. ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms.
      Title: ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms.
    4. HLA-F and LILRB1 Genetic Polymorphisms Associated with Alloimmunisation in Sickle Cell Disease.
      Title: HLA-F and LILRB1 Genetic Polymorphisms Associated with Alloimmunisation in Sickle Cell Disease.
    5. Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients.
      Title: Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients.
    6. EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling.
      Title: EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling.
    7. Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma.
      Title: Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma.
    8. TET2 and LILRB1 mutations are frequent in Epstein-Barr virus-positive diffuse large B-cell lymphoma especially in elderly patients.
      Title: TET2 and LILRB1 mutations are frequent in Epstein-Barr virus-positive diffuse large B-cell lymphoma especially in elderly patients.
    9. Evidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo.
      Title: Evidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo.
    10. Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.
      Title: Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.
    Submit: New GeneRIF Correction See all GeneRIFs (119)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of leukocyte immunoglobulin-like receptor, subfamily B, member 1 (LILRB1) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37515

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables HLA-A specific inhibitory MHC class I receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables HLA-B specific inhibitory MHC class I receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MHC class I protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MHC class I protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables MHC class I protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables MHC class I receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MHC class Ib protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MHC class Ib protein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MHC class Ib receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SH2 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables amyloid-beta binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inhibitory MHC class I receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Fc receptor mediated inhibitory signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in T cell proliferation involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dendritic cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in immune response-inhibiting cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-10-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of CD8-positive, alpha-beta T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of alpha-beta T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cytokine production involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of dendritic cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-10 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of mononuclear cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of osteoclast development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of serotonin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gamma-delta T cell activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of macrophage cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in receptor internalization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte immunoglobulin-like receptor subfamily B member 1
    Names
    CD85 antigen-like family member J
    Ig-like transcript 2
    immunoglobulin heavy chain variable region
    leucocyte Ig-like receptor B1
    leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
    monocyte/macrophage immunoglobulin-like receptor 7
    myeloid inhibitory receptor 7

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081637.3 → NP_001075106.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a shorter 5' UTR and uses two alternate in-frame splice sites in the coding region, compared to variant 1. The resulting protein (isoform 2) is longer, compared to isoform 1.
      Source sequence(s)
      AC245036
      Consensus CDS
      CCDS42614.1
      UniProtKB/TrEMBL
      A0A087WSV6, A0A0G2JNQ6
      Related
      ENSP00000315997.7, ENST00000324602.12
      Conserved Domains (3) summary
      cd00096
      Location:125 → 129
      Ig; Ig strand A [structural motif]
      cd05751
      Location:28 → 118
      IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    2. NM_001081638.4 → NP_001075107.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region and differs in the 5' UTR, compared to variant 1. The resulting protein (isoform 3) is longer, compared to isoform 1.
      Source sequence(s)
      AF283984, AK223310, BC015731, DQ655953, EU915608
      Consensus CDS
      CCDS42615.1
      UniProtKB/TrEMBL
      A0A087WSX8, A0A0G2JQ44
      Related
      ENSP00000379618.3, ENST00000396327.7
      Conserved Domains (3) summary
      cd00096
      Location:125 → 129
      Ig; Ig strand A [structural motif]
      cd05751
      Location:28 → 118
      IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    3. NM_001081639.4 → NP_001075108.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001075108.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region and differs in the 5' UTR, compared to variant 1. The resulting protein (isoform 4) is longer, compared to isoform 1.
      Source sequence(s)
      AF004230, AF283984, AK223310, BC015731, DQ655953, EU915608
      Consensus CDS
      CCDS42616.1
      UniProtKB/TrEMBL
      D9IDM5, D9IDM8
      Related
      ENSP00000379623.4, ENST00000396332.8
      Conserved Domains (3) summary
      cd00096
      Location:125 → 129
      Ig; Ig strand A [structural motif]
      cd05751
      Location:28 → 118
      IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    4. NM_001278398.2 → NP_001265327.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has a shorter 5' UTR, lacks an internal in-frame exon, and uses an alternate splice site in the central coding region, compared to variant 1. The resulting protein (isoform 5) is shorter, compared to isoform 1.
      Source sequence(s)
      AF009006, AF283984, BC015731, EU915608
      Consensus CDS
      CCDS62803.1
      UniProtKB/TrEMBL
      A0A0G2JQ46, A8MVE2
      Related
      ENSP00000379610.1, ENST00000396317.5
      Conserved Domains (3) summary
      cd05751
      Location:27 → 119
      Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
      smart00410
      Location:335 → 397
      IG_like; Immunoglobulin like
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    5. NM_001278399.2 → NP_001265328.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 6 precursor

      See identical proteins and their annotated locations for NP_001265328.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has a shorter 5' UTR, lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The resulting protein (isoform 6) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 6 lacks the transmembrane domain found in isoform 1 and is suspected to be soluble (PMID: 19658091).
      Source sequence(s)
      AK223310, DA991480, EU915608
      UniProtKB/TrEMBL
      F6RVM3
      Conserved Domains (3) summary
      cd05751
      Location:27 → 119
      Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
      smart00410
      Location:335 → 397
      IG_like; Immunoglobulin like
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    6. NM_001388355.1 → NP_001375284.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC245036
      Consensus CDS
      CCDS42615.1
      UniProtKB/TrEMBL
      A0A087WSX8, A0A0G2JQ44
      Conserved Domains (3) summary
      cd00096
      Location:125 → 129
      Ig; Ig strand A [structural motif]
      cd05751
      Location:28 → 118
      IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    7. NM_001388356.1 → NP_001375285.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC245036
      Consensus CDS
      CCDS42616.1
      UniProtKB/TrEMBL
      D9IDM5, D9IDM8
      Conserved Domains (3) summary
      cd00096
      Location:125 → 129
      Ig; Ig strand A [structural motif]
      cd05751
      Location:28 → 118
      IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    8. NM_001388357.1 → NP_001375286.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC245036
      Consensus CDS
      CCDS42615.1
      UniProtKB/TrEMBL
      A0A087WSX8, A0A0G2JQ44
      Conserved Domains (3) summary
      cd00096
      Location:125 → 129
      Ig; Ig strand A [structural motif]
      cd05751
      Location:28 → 118
      IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    9. NM_001388358.1 → NP_001375287.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC245036
      Consensus CDS
      CCDS42614.1
      UniProtKB/TrEMBL
      A0A087WSV6, A0A0G2JNQ6
      Conserved Domains (3) summary
      cd00096
      Location:125 → 129
      Ig; Ig strand A [structural motif]
      cd05751
      Location:28 → 118
      IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    10. NM_006669.7 → NP_006660.4  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_006660.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AF283984, AK223310, AK292156, BC015731
      Consensus CDS
      CCDS42617.1
      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6
      UniProtKB/TrEMBL
      A0A0B4J1W1
      Related
      ENSP00000379622.1, ENST00000396331.5
      Conserved Domains (3) summary
      cd05751
      Location:27 → 119
      Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
      smart00410
      Location:335 → 397
      IG_like; Immunoglobulin like
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    RNA

    1. NR_103518.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has a shorter 5' UTR and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF283984, AK223310, BC015731

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54616322..54638022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438080.1 → XP_047294036.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

      UniProtKB/TrEMBL
      F6TER3

    2. XM_047438081.1 → XP_047294037.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      F6TER3

    3. XM_047438082.1 → XP_047294038.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

      UniProtKB/TrEMBL
      F6TER3

    4. XM_047438083.1 → XP_047294039.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

    5. XM_047438084.1 → XP_047294040.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JNQ6

    6. XM_047438085.1 → XP_047294041.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JQ44

    7. XM_047438086.1 → XP_047294042.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      D9IDM8

    8. XM_047438087.1 → XP_047294043.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

    9. XM_017026192.2 → XP_016881681.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9

      UniProtKB/TrEMBL
      F6RVM3

    10. XM_047438088.1 → XP_047294044.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

      UniProtKB/TrEMBL
      F6RVM3
      Related
      ENSP00000410165.1, ENST00000421584.5

    11. XM_047438089.1 → XP_047294045.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      522708..544408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329622.1 → XP_054185597.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

      UniProtKB/TrEMBL
      F6TER3

    2. XM_054329623.1 → XP_054185598.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      F6TER3

    3. XM_054329624.1 → XP_054185599.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

      UniProtKB/TrEMBL
      D9IDM6

    4. XM_054329625.1 → XP_054185600.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

    5. XM_054329626.1 → XP_054185601.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JNQ6

    6. XM_054329627.1 → XP_054185602.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JQ44

    7. XM_054329628.1 → XP_054185603.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      D9IDM6

    8. XM_054329629.1 → XP_054185604.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

    9. XM_054329630.1 → XP_054185605.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9

      UniProtKB/TrEMBL
      F6RVM3

    10. XM_054329631.1 → XP_054185606.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

      UniProtKB/TrEMBL
      F6RVM3

    11. XM_054329632.1 → XP_054185607.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      521195..542900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331448.1 → XP_054187423.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

      UniProtKB/TrEMBL
      F6TER3

    2. XM_054331449.1 → XP_054187424.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      F6TER3

    3. XM_054331450.1 → XP_054187425.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

      UniProtKB/TrEMBL
      D9IDM9

    4. XM_054331451.1 → XP_054187426.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

    5. XM_054331452.1 → XP_054187427.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JP80

    6. XM_054331453.1 → XP_054187428.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X13

      UniProtKB/TrEMBL
      A0A0G2JQ44

    7. XM_054331454.1 → XP_054187429.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X14

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

    8. XM_054331455.1 → XP_054187430.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JP80

    9. XM_054331457.1 → XP_054187432.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JQ15, A0A0G2JQ44

    10. XM_054331458.1 → XP_054187433.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JP64, D9IDM9

    11. XM_054331459.1 → XP_054187434.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6
      UniProtKB/TrEMBL
      A0A0G2JNM2

    12. XM_054331456.1 → XP_054187431.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JP80

    13. XM_054331460.1 → XP_054187435.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JNR3

    14. XM_054331461.1 → XP_054187436.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JNR3

    15. XM_054331462.1 → XP_054187437.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      598890..620587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333582.1 → XP_054189557.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

      UniProtKB/TrEMBL
      F6TER3

    2. XM_054333583.1 → XP_054189558.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      F6TER3

    3. XM_054333584.1 → XP_054189559.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

      UniProtKB/TrEMBL
      D9IDM9

    4. XM_054333585.1 → XP_054189560.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

    5. XM_054333586.1 → XP_054189561.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JP80

    6. XM_054333588.1 → XP_054189563.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JQ15, A0A0G2JQ44

    7. XM_054333589.1 → XP_054189564.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JP64, D9IDM9

    8. XM_054333591.1 → XP_054189566.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6
      UniProtKB/TrEMBL
      A0A0G2JNM2

    9. XM_054333587.1 → XP_054189562.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

      UniProtKB/TrEMBL
      F6TER3

    10. XM_054333590.1 → XP_054189565.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JP64, D9IDM9

    11. XM_054333592.1 → XP_054189567.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JNR3

    12. XM_054333593.1 → XP_054189568.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JNR3

    13. XM_054333594.1 → XP_054189569.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57709827..57731530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319577.1 → XP_054175552.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

      UniProtKB/TrEMBL
      F6TER3

    2. XM_054319578.1 → XP_054175553.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      F6TER3

    3. XM_054319579.1 → XP_054175554.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

      UniProtKB/TrEMBL
      D9IDM9

    4. XM_054319580.1 → XP_054175555.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

    5. XM_054319581.1 → XP_054175556.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X15

      UniProtKB/TrEMBL
      A0A0G2JP80

    6. XM_054319582.1 → XP_054175557.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X16

      UniProtKB/TrEMBL
      A0A0G2JQ44

    7. XM_054319583.1 → XP_054175558.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X17

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

    8. XM_054319584.1 → XP_054175559.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JP80

    9. XM_054319587.1 → XP_054175562.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JQ44

    10. XM_054319588.1 → XP_054175563.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      D9IDM9

    11. XM_054319590.1 → XP_054175565.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

      UniProtKB/Swiss-Prot
      A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6

    12. XM_054319586.1 → XP_054175561.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

      UniProtKB/TrEMBL
      F6TER3

    13. XM_054319585.1 → XP_054175560.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JP80

    14. XM_054319589.1 → XP_054175564.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      D9IDM9

    15. XM_054319591.1 → XP_054175566.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JNR3

    16. XM_054319592.1 → XP_054175567.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JNR3

    17. XM_054319593.1 → XP_054175568.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NHL6.1 GenPept UniProtKB/Swiss-Prot:Q8NHL6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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