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    Trim43c tripartite motif-containing 43C [ Mus musculus (house mouse) ]

    Gene ID: 666731, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trim43cprovided by MGI
    Official Full Name
    tripartite motif-containing 43Cprovided by MGI
    Primary source
    MGI:MGI:3647365
    See related
    Ensembl:ENSMUSG00000067399 AllianceGenome:MGI:3647365
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trim43; EG666731
    Summary
    Predicted to enable protein kinase binding activity and ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. Is expressed in 4-cell stage embryo; 8-cell stage embryo; and early conceptus. Orthologous to several human genes including TRIM43 (tripartite motif containing 43) and TRIM43B (tripartite motif containing 43B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 2.4), bladder adult (RPKM 1.4) and 20 other tissues See more
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    Genomic context

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    See Trim43c in Genome Data Viewer
    Location:
    9 E3.1; 9 47.24 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (88721217..88736480)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (88839164..88848190)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10634 Neighboring gene STARR-seq mESC enhancer starr_24861 Neighboring gene predicted gene, 53511 Neighboring gene STARR-seq mESC enhancer starr_24862 Neighboring gene predicted gene, 26082 Neighboring gene STARR-seq mESC enhancer starr_24863 Neighboring gene RIKEN cDNA 9330159M07 gene Neighboring gene predicted gene, 26135 Neighboring gene transcription elongation factor B polypeptide 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos. Stanghellini I, et al. Gene Expr Patterns, 2009 Dec. PMID 19703589, Free PMC Article
    2. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol, 2009 May 5. PMID 19468303, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 43C
    Names
    tripartite motif-containing 43

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177858.1 → NP_001171329.1  tripartite motif-containing protein 43C

      See identical proteins and their annotated locations for NP_001171329.1

      Status: PROVISIONAL

      Source sequence(s)
      CT030259, CT030651
      Consensus CDS
      CCDS52883.1
      UniProtKB/Swiss-Prot
      P86449
      UniProtKB/TrEMBL
      A0A087WPC1
      Related
      ENSMUSP00000129255.3, ENSMUST00000163255.9
      Conserved Domains (3) summary
      cl00034
      Location:87 → 139
      Bbox_SF; B-box-type zinc finger superfamily
      cl02614
      Location:329 → 441
      SPRY; SPRY domain
      cl17238
      Location:14 → 58
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      88721217..88736480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511358.5 → XP_006511421.1  tripartite motif-containing protein 43C isoform X1

      See identical proteins and their annotated locations for XP_006511421.1

      UniProtKB/Swiss-Prot
      P86449
      UniProtKB/TrEMBL
      A0A087WPC1
      Conserved Domains (3) summary
      cl00034
      Location:87 → 139
      Bbox_SF; B-box-type zinc finger superfamily
      cl02614
      Location:329 → 441
      SPRY; SPRY domain
      cl17238
      Location:14 → 58
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P86449.1 GenPept UniProtKB/Swiss-Prot:P86449

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