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    Mrpl4 mitochondrial ribosomal protein L4 [ Mus musculus (house mouse) ]

    Gene ID: 66163, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrpl4provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L4provided by MGI
    Primary source
    MGI:MGI:2137210
    See related
    Ensembl:ENSMUSG00000003299 AllianceGenome:MGI:2137210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110017G11Rik
    Summary
    Predicted to be a structural constituent of ribosome. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; liver; pancreas epithelium; and submandibular gland primordium. Orthologous to human MRPL4 (mitochondrial ribosomal protein L4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 78.0), kidney adult (RPKM 50.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl4 in Genome Data Viewer
    Location:
    9 A3; 9 7.69 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20907040..20920135)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21001252..21008839)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 1 Neighboring gene microRNA 7081 Neighboring gene STARR-seq mESC enhancer starr_23470 Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene STARR-seq mESC enhancer starr_23474 Neighboring gene STARR-seq mESC enhancer starr_23475 Neighboring gene STARR-seq mESC enhancer starr_23476 Neighboring gene intercellular adhesion molecule 1 Neighboring gene intercellular adhesion molecule 4, Landsteiner-Wiener blood group

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation. Liu HB, et al. Adv Sci (Weinh), 2019 Aug 7. PMID 31406667, Free PMC Article
    2. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. Suzuki T, et al. J Biol Chem, 2001 Jun 15. PMID 11279069
    3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    4. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL4m
    Names
    39S ribosomal protein L4, mitochondrial
    L4mt
    MRP-L4
    NP_001344828.1
    NP_075656.2
    XP_006510603.1
    XP_036011066.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357899.1 → NP_001344828.1  large ribosomal subunit protein uL4m isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159314
      UniProtKB/TrEMBL
      A0A1L1SSY9
      Related
      ENSMUSP00000150112.2, ENSMUST00000214124.2
      Conserved Domains (1) summary
      pfam00573
      Location:81 → 278
      Ribosomal_L4; Ribosomal protein L4/L1 family

    2. NM_023167.2 → NP_075656.2  large ribosomal subunit protein uL4m isoform 2

      See identical proteins and their annotated locations for NP_075656.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice junctions compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC159314, AK002464, BC051685
      Consensus CDS
      CCDS40548.1
      UniProtKB/Swiss-Prot
      Q811L8, Q8JZU9, Q9DCU6, Q9JJB3
      UniProtKB/TrEMBL
      A0A1L1SSY9
      Related
      ENSMUSP00000003386.6, ENSMUST00000003386.7
      Conserved Domains (1) summary
      pfam00573
      Location:81 → 272
      Ribosomal_L4; Ribosomal protein L4/L1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20907040..20920135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510540.3 → XP_006510603.1  large ribosomal subunit protein uL4m isoform X1

      UniProtKB/TrEMBL
      A0A1L1SSY9
      Conserved Domains (1) summary
      pfam00573
      Location:81 → 266
      Ribosomal_L4; Ribosomal protein L4/L1 family

    2. XM_036155173.1 → XP_036011066.1  large ribosomal subunit protein uL4m isoform X2

      Conserved Domains (1) summary
      pfam00573
      Location:66 → 189
      Ribosomal_L4; Ribosomal protein L4/L1 family

    RNA

    1. XR_003947968.2 RNA Sequence

    2. XR_379129.3 RNA Sequence

    3. XR_001778962.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCU6.1 GenPept UniProtKB/Swiss-Prot:Q9DCU6

    Gene LinkOut

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