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    Dpy19l2 dpy-19 like 2 [ Mus musculus (house mouse) ]

    Gene ID: 320752, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dpy19l2provided by MGI
    Official Full Name
    dpy-19 like 2provided by MGI
    Primary source
    MGI:MGI:2444662
    See related
    Ensembl:ENSMUSG00000085576 AllianceGenome:MGI:2444662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm18376; 4932443J21Rik
    Summary
    Predicted to enable mannosyltransferase activity. Involved in spermatid development. Located in nuclear inner membrane. Is expressed in cerebral cortex. Human ortholog(s) of this gene implicated in spermatogenic failure 9. Orthologous to several human genes including DPY19L2 (dpy-19 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 21.8) See more
    Orthologs
    human all
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    Genomic context

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    See Dpy19l2 in Genome Data Viewer
    Location:
    9 A4; 9 10.22 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (24468343..24607752, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (24557047..24696457, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10701 Neighboring gene predicted gene, 22380 Neighboring gene dpy-19 like C-mannosyltransferase 1 Neighboring gene predicted gene, 57533 Neighboring gene STARR-seq mESC enhancer starr_23585 Neighboring gene STARR-seq mESC enhancer starr_23586 Neighboring gene cysteine-rich perinuclear theca 4 Neighboring gene STARR-seq mESC enhancer starr_23587 Neighboring gene STARR-seq mESC enhancer starr_23588 Neighboring gene T-box 20 Neighboring gene predicted gene, 29824

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization of phospholipase Cζ in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation. Escoffier J, et al. Mol Hum Reprod, 2015 Feb. PMID 25354701, Free PMC Article
    2. Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development. Yassine S, et al. Mol Hum Reprod, 2015 Feb. PMID 25354700, Free PMC Article
    3. Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope. Yassine S, et al. PLoS One, 2015. PMID 25775128, Free PMC Article
    4. Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus. Pierre V, et al. Development, 2012 Aug. PMID 22764053
    5. FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice. Castaneda JM, et al. J Cell Sci, 2021 Nov 1. PMID 34471926, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In Dpy19l2 knock-out round spermatids, the detachment of the acrosome leads to Sun5 and lamin B1 relocalization, confirming that Sun5 protein is excluded from the nuclear envelope facing the acrosome.
      Title: Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.
    2. Absence of Dpy19l2 leads to the destabilization of both the nuclear dense lamina and the junction between the acroplaxome and the nuclear envelope in spermatids. Consequently, the acrosome and the manchette fail to be linked to the nucleus.
      Title: Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable C-mannosyltransferase DPY19L2
    Names
    dpy-19-like protein 2
    protein dpy-19 homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166207.1 → NP_001159679.1  probable C-mannosyltransferase DPY19L2

      See identical proteins and their annotated locations for NP_001159679.1

      Status: VALIDATED

      Source sequence(s)
      AK029497, AK030128, AV254516
      Consensus CDS
      CCDS52743.1
      UniProtKB/Swiss-Prot
      P0CW70
      Related
      ENSMUSP00000132092.2, ENSMUST00000133010.4
      Conserved Domains (1) summary
      pfam10034
      Location:130 → 771
      Dpy19; Q-cell neuroblast polarization

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      24468343..24607752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510428.5 → XP_006510491.1  probable C-mannosyltransferase DPY19L2 isoform X2

      Conserved Domains (1) summary
      pfam10034
      Location:130 → 730
      Dpy19; Q-cell neuroblast polarisation

    2. XM_006510427.5 → XP_006510490.1  probable C-mannosyltransferase DPY19L2 isoform X1

      Conserved Domains (1) summary
      pfam10034
      Location:130 → 745
      Dpy19; Q-cell neuroblast polarisation

    3. XM_011242557.3 → XP_011240859.1  probable C-mannosyltransferase DPY19L2 isoform X4

      Conserved Domains (1) summary
      pfam10034
      Location:1 → 502
      Dpy19; Q-cell neuroblast polarisation

    4. XM_030244421.1 → XP_030100281.1  probable C-mannosyltransferase DPY19L2 isoform X5

      Conserved Domains (1) summary
      pfam10034
      Location:4 → 411
      Dpy19; Q-cell neuroblast polarisation

    5. XM_011242556.4 → XP_011240858.1  probable C-mannosyltransferase DPY19L2 isoform X3

      Conserved Domains (1) summary
      pfam10034
      Location:130 → 531
      Dpy19; Q-cell neuroblast polarisation

    6. XM_017313436.2 → XP_017168925.1  probable C-mannosyltransferase DPY19L2 isoform X6

      Conserved Domains (1) summary
      pfam10034
      Location:130 → 378
      Dpy19; Q-cell neuroblast polarisation

    RNA

    1. XR_870529.4 RNA Sequence

    2. XR_001778933.3 RNA Sequence

    3. XR_379122.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_020863.1: Suppressed sequence

      Description
      NG_020863.1: This RefSeq was permanently suppressed because it is now thought that this gene is not a pseudogene.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CW70.1 GenPept UniProtKB/Swiss-Prot:P0CW70

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