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    Nxpe4 neurexophilin and PC-esterase domain family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 244853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nxpe4provided by MGI
    Official Full Name
    neurexophilin and PC-esterase domain family, member 4provided by MGI
    Primary source
    MGI:MGI:1924792
    See related
    Ensembl:ENSMUSG00000044229 AllianceGenome:MGI:1924792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam55d; C130036J11; D930028F11Rik
    Summary
    Predicted to be located in extracellular region. Orthologous to human NXPE4 (neurexophilin and PC-esterase domain family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 3.1), liver E14.5 (RPKM 3.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nxpe4 in Genome Data Viewer
    Location:
    9 A5.3; 9 26.39 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (48073302..48311325)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (48162004..48400025)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32016 Neighboring gene STARR-seq mESC enhancer starr_24057 Neighboring gene STARR-seq mESC enhancer starr_24058 Neighboring gene predicted gene, 40518 Neighboring gene STARR-positive B cell enhancer mm9_chr9:48025608-48025909 Neighboring gene predicted gene, 57543 Neighboring gene predicted gene, 51672 Neighboring gene STARR-seq mESC enhancer starr_24065 Neighboring gene neurexophilin and PC-esterase domain family, member 2 Neighboring gene neurexophilin and PC-esterase domain family, member 1, pseudogene Neighboring gene predicted gene, 32131 Neighboring gene NHP2 non-histone chromosome protein 2-like 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The genomic determinants of alcohol preference in mice. Tabakoff B, et al. Mamm Genome, 2008 May. PMID 18563486, Free PMC Article
    2. Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL. Yaguchi H, et al. Genomics, 2005 May. PMID 15820311
    3. Candidate genes and their regulatory elements: alcohol preference and tolerance. Saba L, et al. Mamm Genome, 2006 Jun. PMID 16783646
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NXPE family member 4
    Names
    family with sequence similarity 55, member D
    protein FAM55D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172921.3 → NP_766509.2  NXPE family member 4

      See identical proteins and their annotated locations for NP_766509.2

      Status: VALIDATED

      Source sequence(s)
      AC154373, AC160992
      Consensus CDS
      CCDS23152.1
      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Related
      ENSMUSP00000091375.5, ENSMUST00000093853.5
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      48073302..48311325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154984.1 → XP_036010877.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    2. XM_030244373.1 → XP_030100233.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    3. XM_036154989.1 → XP_036010882.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    4. XM_017313377.2 → XP_017168866.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    5. XM_036154996.1 → XP_036010889.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    6. XM_036154986.1 → XP_036010879.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    7. XM_017313375.3 → XP_017168864.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    8. XM_036154995.1 → XP_036010888.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    9. XM_030244370.2 → XP_030100230.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    10. XM_036155001.1 → XP_036010894.1  NXPE family member 4 isoform X2

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    11. XM_030244368.1 → XP_030100228.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    12. XM_030244367.1 → XP_030100227.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    13. XM_036154991.1 → XP_036010884.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    14. XM_017313379.2 → XP_017168868.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    15. XM_036154983.1 → XP_036010876.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    16. XM_011242528.3 → XP_011240830.1  NXPE family member 4 isoform X4

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    17. XM_036154994.1 → XP_036010887.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    18. XM_030244369.1 → XP_030100229.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    19. XM_036154997.1 → XP_036010890.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    20. XM_030244366.1 → XP_030100226.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    21. XM_036154987.1 → XP_036010880.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    22. XM_036154985.1 → XP_036010878.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    23. XM_006510325.2 → XP_006510388.1  NXPE family member 4 isoform X3

      See identical proteins and their annotated locations for XP_006510388.1

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Related
      ENSMUSP00000149741.2, ENSMUST00000215780.2
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    24. XM_030244376.2 → XP_030100236.1  NXPE family member 4 isoform X4

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    25. XM_030244371.1 → XP_030100231.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    26. XM_036154998.1 → XP_036010891.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    27. XM_017313384.1 → XP_017168873.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    28. XM_036154988.1 → XP_036010881.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    29. XM_036154993.1 → XP_036010886.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    30. XM_036154999.1 → XP_036010892.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    31. XM_030244374.1 → XP_030100234.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    32. XM_036154990.1 → XP_036010883.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    33. XM_017313378.1 → XP_017168867.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    34. XM_030244377.2 → XP_030100237.1  NXPE family member 4 isoform X4

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    35. XM_030244375.1 → XP_030100235.1  NXPE family member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q0VGS9, Q52KP5, Q8BKY4
      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    36. XM_036155000.1 → XP_036010893.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin

    37. XM_036154992.1 → XP_036010885.1  NXPE family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UWC0
      Conserved Domains (1) summary
      pfam06312
      Location:129 → 255
      Neurexophilin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q52KP5.1 GenPept UniProtKB/Swiss-Prot:Q52KP5

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