Coro2b coronin, actin binding protein, 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Coro2bprovided by MGI
Official Full Name: coronin, actin binding protein, 2Bprovided by MGI
Primary source: MGI:MGI:2444283
See related: Ensembl:ENSMUSG00000041729 AllianceGenome:MGI:2444283
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLIPINC; E130012P22Rik
Summary: Predicted to enable actin filament binding activity; talin binding activity; and vinculin binding activity. Acts upstream of or within focal adhesion assembly; negative regulation of stress fiber assembly; and regulation of glomerular filtration. Located in focal adhesion. Is expressed in cerebral cortex; dorsal root ganglion; and hippocampus. Orthologous to human CORO2B (coronin 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 45.9), cortex adult (RPKM 26.6) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 33.71 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (62326770..62444326, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (62419490..62537044, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition.
Title: Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition.
Coronin 2B regulates dendrite outgrowth by modulating actin dynamics.
Title: Coronin 2B regulates dendrite outgrowth by modulating actin dynamics.
CORO2B is a novel podocyte enriched protein influencing cytoskeletal plasticity and stress adaptation.
Title: The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236156

D8Rat212 (e-PCR), detects polymorphism
- UniSTS:228278

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables talin binding	ISO Inferred from Sequence Orthology more info	PubMed
enables vinculin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of establishment of protein localization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of establishment of protein localization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info	PubMed
located_in stress fiber	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: coronin-2B

Names: E130012P22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175484.3 → NP_780693.2 coronin-2B

Status: VALIDATED

Source sequence(s)

AK087414, BB647296, BC062649

Consensus CDS

CCDS23264.2

UniProtKB/Swiss-Prot

Q6P5U9, Q8BH44

Related

ENSMUSP00000041826.6, ENSMUST00000048043.12

Conserved Domains (2) summary

sd00039
Location:45 → 85

7WD40; WD40 repeat [structural motif]

cl29593
Location:15 → 460

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

62326770..62444326 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511100.4 → XP_006511163.1 coronin-2B isoform X3

UniProtKB/Swiss-Prot

Q8BH44

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 455

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006511094.5 → XP_006511157.3 coronin-2B isoform X1

Conserved Domains (2) summary

sd00039
Location:65 → 105

7WD40; WD40 repeat [structural motif]

cl29593
Location:35 → 480

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036154902.1 → XP_036010795.1 coronin-2B isoform X3

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 455

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006511099.5 → XP_006511162.1 coronin-2B isoform X3

UniProtKB/Swiss-Prot

Q8BH44

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 455

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006511097.5 → XP_006511160.1 coronin-2B isoform X3

UniProtKB/Swiss-Prot

Q8BH44

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 455

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006511098.5 → XP_006511161.1 coronin-2B isoform X3

UniProtKB/Swiss-Prot

Q8BH44

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 455

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006511095.3 → XP_006511158.1 coronin-2B isoform X2

Conserved Domains (2) summary

sd00039
Location:43 → 83

7WD40; WD40 repeat [structural motif]

cl29593
Location:13 → 458

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...