Bnip2 BCL2/adenovirus E1B interacting protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bnip2provided by MGI
Official Full Name: BCL2/adenovirus E1B interacting protein 2provided by MGI
Primary source: MGI:MGI:109327
See related: Ensembl:ENSMUSG00000011958 AllianceGenome:MGI:109327
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nip21; BNIP2beta; 5730523P12Rik
Summary: Acts upstream of or within several processes, including blastocyst development; centrosome cycle; and positive regulation of intracellular signal transduction. Located in centriole and spindle pole centrosome. Is expressed in neocortex. Orthologous to human BNIP2 (BCL2 interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 17.0), CNS E11.5 (RPKM 12.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 39.15 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (69896660..69918941)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (69989438..70011659)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that mBNIP-21 functions without need of the Bcl-2 homology 3 domain but its Cdc42GAP homology domain is critical for its activity in inducing cell elongation, membrane protrusions and apoptotic cell death.
Title: Pro-apoptotic activity of mBNIP-21 depends on its BNIP-2 and Cdc42GAP homology (BCH) domain and is enhanced by coxsackievirus B3 infection.
Cdo also interacts with Bnip-2, a protein that binds the small guanosine triphosphatase (GTPase) Cdc42 and a negative regulator of Cdc42, Cdc42 GTPase-activating protein (GAP).
Title: A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation.
Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptosis (Nip21)
Title: Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptotic cell death via a mitochondria-dependent pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bnip2 (e-PCR), detects polymorphism
- UniSTS:532248

AF035207 (e-PCR)
- UniSTS:185795

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within striated muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle pole centrosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

Names: BCL2/adenovirus E1B 19 kDa-interacting protein 2 beta; BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2; BCL2/adenovirus E1B interacting protein 1, NIP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008238.3 → NP_001008239.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform alpha

See identical proteins and their annotated locations for NP_001008239.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform alpha.

Source sequence(s)

AC137108

Consensus CDS

CCDS23318.1

UniProtKB/TrEMBL

Q91VL0, Q9D632

Related

ENSMUSP00000082513.7, ENSMUST00000085393.13

Conserved Domains (2) summary

cd00170
Location:147 → 290

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

pfam12496
Location:49 → 163

BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
NM_001374750.1 → NP_001361679.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (c).

Source sequence(s)

AC137108, AK014659

Consensus CDS

CCDS90612.1

UniProtKB/TrEMBL

G5E8U9, Q9D632

Related

ENSMUSP00000113466.2, ENSMUST00000117450.8

Conserved Domains (2) summary

cd00170
Location:147 → 290

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

pfam12496
Location:50 → 163

BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
NM_016787.4 → NP_058067.2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform beta

See identical proteins and their annotated locations for NP_058067.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame exon in the 3' coding region compared to variant alpha. It encodes isoform beta which is longer than isoform alpha.

Source sequence(s)

AC137108, AK054288

Consensus CDS

CCDS23319.1

UniProtKB/Swiss-Prot

O54940, Q8K4H0

UniProtKB/TrEMBL

Q9D632

Related

ENSMUSP00000034754.6, ENSMUST00000034754.12

Conserved Domains (2) summary

cd00170
Location:147 → 290

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

pfam12496
Location:49 → 163

BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

69896660..69918941

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510791.5 → XP_006510854.2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X1

UniProtKB/TrEMBL

Q9D632

Conserved Domains (2) summary

cd00170
Location:147 → 290

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

pfam12496
Location:50 → 163

BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
XM_006510793.5 → XP_006510856.2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X2

UniProtKB/TrEMBL

Q9D632

Conserved Domains (2) summary

cd00170
Location:147 → 290

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

pfam12496
Location:50 → 163

BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
XM_036154575.1 → XP_036010468.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X3

Conserved Domains (1) summary

cd00170
Location:16 → 159

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
XM_036154578.1 → XP_036010471.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X4

Conserved Domains (1) summary

cd00170
Location:16 → 159

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
XM_036154576.1 → XP_036010469.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X3

Conserved Domains (1) summary

cd00170
Location:16 → 159

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
XM_036154577.1 → XP_036010470.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X3

Conserved Domains (1) summary

cd00170
Location:16 → 159

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...