Usp38 ubiquitin specific peptidase 38 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp38provided by MGI
Official Full Name: ubiquitin specific peptidase 38provided by MGI
Primary source: MGI:MGI:1922091
See related: Ensembl:ENSMUSG00000038250 AllianceGenome:MGI:1922091
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1891; 4631402N15Rik; 4833420O05Rik
Summary: Predicted to enable cysteine-type deubiquitinase activity and protein sequestering activity. Predicted to be involved in negative regulation of innate immune response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of protein stability. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human USP38 (ubiquitin specific peptidase 38). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 6.0), thymus adult (RPKM 5.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 38.68 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (81707353..81741631, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (80980724..81015013, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP38 exacerbates pressure overload-induced left ventricular electrical remodeling.
Title: USP38 exacerbates pressure overload-induced left ventricular electrical remodeling.
Ubiquitin specific protease 38 aggravates pathological cardiac remodeling by stabilizing phospho-TBK1.
Title: Ubiquitin specific protease 38 aggravates pathological cardiac remodeling by stabilizing phospho-TBK1.
Ubiquitin-specific protease 38 promotes inflammatory atrial fibrillation induced by pressure overload.
Title: Ubiquitin-specific protease 38 promotes inflammatory atrial fibrillation induced by pressure overload.
USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice.
Title: USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice.
Mechanistically, USP38 directly associated with JunB, deubiquitinated Lys-48-linked poly-ubiquitination of JunB, and consequently blocked TCR-induced JunB turnover. USP38 represents the first identified deubiquitinase specifically for Th2 immunity and the associated asthma.
Title: USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.
USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome.
Title: USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU044701 (e-PCR)
- UniSTS:159779

AW544820 (e-PCR)
- UniSTS:179769

RH124306 (e-PCR)
- UniSTS:161128

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	IEA Inferred from Electronic Annotation more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K33-linked deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 38

Names: deubiquitinating enzyme 38; ubiquitin specific protease 38; ubiquitin thioesterase 38; ubiquitin thiolesterase 38; ubiquitin-specific-processing protease 38

NP_081830.2

EC 3.4.19.12

XP_006531513.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027554.2 → NP_081830.2 ubiquitin carboxyl-terminal hydrolase 38

See identical proteins and their annotated locations for NP_081830.2

Status: PROVISIONAL

Source sequence(s)

BC054404

Consensus CDS

CCDS22444.1

UniProtKB/Swiss-Prot

Q8BW70, Q8BWL1, Q8BX03

UniProtKB/TrEMBL

Q6ZPG3

Related

ENSMUSP00000039943.7, ENSMUST00000042724.8

Conserved Domains (2) summary

cd02664
Location:446 → 947

Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:445 → 946

UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

81707353..81741631 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531450.5 → XP_006531513.1 ubiquitin carboxyl-terminal hydrolase 38 isoform X1

Conserved Domains (1) summary

cd02664
Location:112 → 613

Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...