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    Nanos3 nanos C2HC-type zinc finger 3 [ Mus musculus (house mouse) ]

    Gene ID: 244551, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nanos3provided by MGI
    Official Full Name
    nanos C2HC-type zinc finger 3provided by MGI
    Primary source
    MGI:MGI:2675387
    See related
    Ensembl:ENSMUSG00000056155 AllianceGenome:MGI:2675387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nos3
    Summary
    Enables RNA binding activity. Involved in regulation of cell cycle; regulation of translation; and spermatogenesis. Acts upstream of or within negative regulation of apoptotic signaling pathway and oogenesis. Located in P-body; cytoplasmic stress granule; and nucleus. Is expressed in several structures, including gonad; metanephros; primordial germ cell; and telencephalon. Orthologous to human NANOS3 (nanos C2HC-type zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 2.1), whole brain E14.5 (RPKM 2.0) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nanos3 in Genome Data Viewer
    Location:
    8 C2; 8 40.45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84900359..84911396, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84173733..84176552, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene podocan-like 1 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene break repair meiotic recombinase recruitment factor 1 Neighboring gene microRNA 181d Neighboring gene microRNA 181c Neighboring gene STARR-seq mESC enhancer starr_22111 Neighboring gene STARR-seq mESC enhancer starr_22112 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86721349-86721458 Neighboring gene predicted gene, 26887 Neighboring gene microRNA 23a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC141148

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germ cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in germ cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of translation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in spermatogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357361.1NP_001344290.1  nanos homolog 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159266
      Consensus CDS
      CCDS90425.1
      UniProtKB/TrEMBL
      Q0VDU5
      Related
      ENSMUSP00000147775.2, ENSMUST00000210202.2
      Conserved Domains (1) summary
      pfam05741
      Location:57109
      zf-nanos; Nanos RNA binding domain
    2. NM_194059.2NP_918948.1  nanos homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_918948.1

      Status: VALIDATED

      Source sequence(s)
      AC159266
      Consensus CDS
      CCDS22470.1
      UniProtKB/Swiss-Prot
      P60324, Q0VDU6
      Related
      ENSMUSP00000067385.6, ENSMUST00000070102.6
      Conserved Domains (1) summary
      pfam05741
      Location:57109
      zf-nanos; Nanos RNA binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84900359..84911396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154034.1XP_036009927.1  nanos homolog 3 isoform X1

    2. XM_036154035.1XP_036009928.1  nanos homolog 3 isoform X2