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    Acsl1 acyl-CoA synthetase long-chain family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 14081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acsl1provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 1provided by MGI
    Primary source
    MGI:MGI:102797
    See related
    Ensembl:ENSMUSG00000018796 AllianceGenome:MGI:102797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acs; Acas; FACS; Acas1; Facl2; LACS1; LACS 1
    Summary
    The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in liver E18 (RPKM 94.6), subcutaneous fat pad adult (RPKM 79.5) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acsl1 in Genome Data Viewer
    Location:
    8 B1.1; 8 26.36 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46924214..46989088)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46471037..46536051)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:47396583-47396884 Neighboring gene predicted gene, 39168 Neighboring gene STARR-seq mESC enhancer starr_21381 Neighboring gene predicted gene, 30931 Neighboring gene STARR-seq mESC enhancer starr_21383 Neighboring gene STARR-seq mESC enhancer starr_21384 Neighboring gene STARR-positive B cell enhancer ABC_E2261 Neighboring gene STARR-positive B cell enhancer ABC_E6635 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:47637172-47637355 Neighboring gene centromere protein U Neighboring gene primase and polymerase (DNA-directed) Neighboring gene predicted gene 45607

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration. Li Y, et al. Life Sci, 2022 Apr 1. PMID 35122795
    2. Proteolipid domains form in biomimetic and cardiac mitochondrial vesicles and are regulated by cardiolipin concentration but not monolyso-cardiolipin. Pennington ER, et al. J Biol Chem, 2018 Oct 12. PMID 30158245, Free PMC Article
    3. Modeling the Transition From Decompensated to Pathological Hypertrophy. Pascual F, et al. J Am Heart Assoc, 2018 Apr 5. PMID 29622588, Free PMC Article
    4. Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function. Zhao L, et al. J Biol Chem, 2019 May 31. PMID 30975900, Free PMC Article
    5. Acyl CoA synthetase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male versus female mice. Goldenberg JR, et al. J Mol Cell Cardiol, 2016 May. PMID 26995156, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
      Title: The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
    2. ACSL1 positively regulates adipogenic differentiation.
      Title: ACSL1 positively regulates adipogenic differentiation.
    3. shRNA-mediated down-regulation of Acsl1 reverses skeletal muscle insulin resistance in obese C57BL6/J mice.
      Title: shRNA-mediated down-regulation of Acsl1 reverses skeletal muscle insulin resistance in obese C57BL6/J mice.
    4. Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of omega-O-acylceramide in mice.
      Title: Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice.
    5. Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1.
      Title: Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1.
    6. PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis.
      Title: PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis.
    7. ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease.
      Title: ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease.
    8. Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
      Title: Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
    9. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
      Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
    10. Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis.
      Title: Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oleoyl-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oleoyl-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phytanate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phytanate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pristanate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adiponectin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid import into cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of long-chain fatty acid import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of long-chain fatty acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oleic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in xenobiotic catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase 1
    Names
    acetate-CoA ligase
    acetyl-CoA synthetase
    acetyl-Coenzyme A synthetase 1 (ADP forming)
    arachidonate--CoA ligase
    fatty acid Coenzyme A ligase, long chain 2
    long-chain acyl-CoA synthetase 1
    phytanate--CoA ligase
    NP_001289092.1
    NP_001411721.1
    NP_001411722.1
    NP_001411723.1
    NP_032007.2
    XP_006509325.2
    XP_006509328.1
    XP_006509329.1
    XP_017168052.1
    XP_030099145.1
    XP_036009645.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302163.2 → NP_001289092.1  long-chain-fatty-acid--CoA ligase 1 isoform 1

      See identical proteins and their annotated locations for NP_001289092.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AC119267, AC138367
      Consensus CDS
      CCDS22291.1
      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Related
      ENSMUSP00000106001.2, ENSMUST00000110372.9
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. NM_001424792.1 → NP_001411721.1  long-chain-fatty-acid--CoA ligase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC119267, AC138367
      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5

    3. NM_001424793.1 → NP_001411722.1  long-chain-fatty-acid--CoA ligase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119267, AC138367

    4. NM_001424794.1 → NP_001411723.1  long-chain-fatty-acid--CoA ligase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119267, AC138367

    5. NM_007981.5 → NP_032007.2  long-chain-fatty-acid--CoA ligase 1 isoform 1

      See identical proteins and their annotated locations for NP_032007.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a distinct 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AC119267, AC138367
      Consensus CDS
      CCDS22291.1
      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Related
      ENSMUSP00000034046.6, ENSMUST00000034046.13
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      46924214..46989088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312563.3 → XP_017168052.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. XM_006509266.4 → XP_006509329.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509329.1

      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    3. XM_006509265.4 → XP_006509328.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509328.1

      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    4. XM_030243285.2 → XP_030099145.1  long-chain-fatty-acid--CoA ligase 1 isoform X3

      UniProtKB/TrEMBL
      D3Z041
      Related
      ENSMUSP00000106000.2, ENSMUST00000110371.8
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    5. XM_006509262.4 → XP_006509325.2  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509325.2

      UniProtKB/Swiss-Prot
      P41216, Q6GTG6, Q9DBK5
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    6. XM_036153752.1 → XP_036009645.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

      Conserved Domains (1) summary
      cl17068
      Location:1 → 370
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RNA

    1. XR_004934769.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41216.2 GenPept UniProtKB/Swiss-Prot:P41216

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