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    Jakmip3 janus kinase and microtubule interacting protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 74004, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Jakmip3provided by MGI
    Official Full Name
    janus kinase and microtubule interacting protein 3provided by MGI
    Primary source
    MGI:MGI:1921254
    See related
    Ensembl:ENSMUSG00000056856 AllianceGenome:MGI:1921254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4091; 6330417G02Rik
    Summary
    Predicted to enable kinase binding activity and microtubule binding activity. Predicted to be located in Golgi apparatus. Orthologous to human JAKMIP3 (Janus kinase and microtubule interacting protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 6.7), cortex adult (RPKM 6.6) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Jakmip3 in Genome Data Viewer
    Location:
    7 F4; 7 83.0 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138542057..138663893)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (138940730..139083976)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20412 Neighboring gene STARR-positive B cell enhancer ABC_E11372 Neighboring gene gamma-glutamyl hydrolase pseudogene Neighboring gene BCL2/adenovirus E1B interacting protein 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_20414 Neighboring gene dihydropyrimidinase-like 4 Neighboring gene serine/threonine kinase 32C Neighboring gene STARR-positive B cell enhancer ABC_E11373 Neighboring gene STARR-positive B cell enhancer ABC_E296 Neighboring gene leucine rich repeat containing 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E (-/-) mice. Mu X, et al. Free Radic Biol Med, 2024 Apr. PMID 38461872
    2. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E [-/-] mice.
      Title: The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E (-/-) mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4091

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    janus kinase and microtubule-interacting protein 3
    Names
    neuroendocrine long coiled-coil protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433479.1 → NP_001420408.1  janus kinase and microtubule-interacting protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC174642, AC241620, AEKQ02141041, AEKQ02141042

    2. NM_028708.2 → NP_082984.1  janus kinase and microtubule-interacting protein 3 isoform 1

      See identical proteins and their annotated locations for NP_082984.1

      Status: VALIDATED

      Source sequence(s)
      AK018189, AK220482
      UniProtKB/Swiss-Prot
      Q0VDR4, Q0VDR5, Q5DTN8, Q9CU41
      Related
      ENSMUSP00000130207.4, ENSMUST00000166163.4
      Conserved Domains (2) summary
      TIGR02168
      Location:8 → 816
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16034
      Location:430 → 626
      JAKMIP_CC3; JAKMIP CC3 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      138542057..138663893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153483.1 → XP_036009376.1  janus kinase and microtubule-interacting protein 3 isoform X2

      Conserved Domains (2) summary
      PHA02682
      Location:411 → 530
      PHA02682; ORF080 virion core protein; Provisional
      COG1196
      Location:8 → 360
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_036153486.1 → XP_036009379.1  janus kinase and microtubule-interacting protein 3 isoform X4

      Conserved Domains (2) summary
      PHA02682
      Location:339 → 458
      PHA02682; ORF080 virion core protein; Provisional
      COG1196
      Location:13 → 315
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_036153488.1 → XP_036009381.1  janus kinase and microtubule-interacting protein 3 isoform X5

      Conserved Domains (2) summary
      PHA02682
      Location:337 → 456
      PHA02682; ORF080 virion core protein; Provisional
      COG1196
      Location:13 → 301
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_036153490.1 → XP_036009383.1  janus kinase and microtubule-interacting protein 3 isoform X7

      Conserved Domains (2) summary
      PHA02682
      Location:336 → 455
      PHA02682; ORF080 virion core protein; Provisional
      COG1196
      Location:13 → 300
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_036153485.1 → XP_036009378.1  janus kinase and microtubule-interacting protein 3 isoform X4

      Conserved Domains (2) summary
      PHA02682
      Location:339 → 458
      PHA02682; ORF080 virion core protein; Provisional
      COG1196
      Location:13 → 315
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_036153487.1 → XP_036009380.1  janus kinase and microtubule-interacting protein 3 isoform X5

      Conserved Domains (2) summary
      PHA02682
      Location:337 → 456
      PHA02682; ORF080 virion core protein; Provisional
      COG1196
      Location:13 → 301
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_036153484.1 → XP_036009377.1  janus kinase and microtubule-interacting protein 3 isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:8 → 366
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam16034
      Location:430 → 533
      JAKMIP_CC3; JAKMIP CC3 domain

    8. XM_036153481.1 → XP_036009374.1  janus kinase and microtubule-interacting protein 3 isoform X1

      Conserved Domains (2) summary
      TIGR02168
      Location:8 → 825
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16034
      Location:430 → 627
      JAKMIP_CC3; JAKMIP CC3 domain

    9. XM_036153482.1 → XP_036009375.1  janus kinase and microtubule-interacting protein 3 isoform X1

      Conserved Domains (2) summary
      TIGR02168
      Location:8 → 825
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16034
      Location:430 → 627
      JAKMIP_CC3; JAKMIP CC3 domain

    10. XM_036153489.1 → XP_036009382.1  janus kinase and microtubule-interacting protein 3 isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:26 → 303
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam16034
      Location:358 → 462
      JAKMIP_CC3; JAKMIP CC3 domain

    11. XM_036153491.1 → XP_036009384.1  janus kinase and microtubule-interacting protein 3 isoform X8

      Conserved Domains (2) summary
      COG1196
      Location:26 → 301
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam16034
      Location:356 → 460
      JAKMIP_CC3; JAKMIP CC3 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DTN8.2 GenPept UniProtKB/Swiss-Prot:Q5DTN8

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