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    Shank1 SH3 and multiple ankyrin repeat domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 243961, updated on 9-Dec-2024

    Summary

    Official Symbol
    Shank1provided by MGI
    Official Full Name
    SH3 and multiple ankyrin repeat domains 1provided by MGI
    Primary source
    MGI:MGI:3613677
    See related
    Ensembl:ENSMUSG00000038738 AllianceGenome:MGI:3613677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. A structural constituent of postsynaptic density. Involved in several processes, including dendritic spine morphogenesis; learning or memory; and regulation of signal transduction. Acts upstream of or within negative regulation of actin filament bundle assembly. Located in dendritic spine; excitatory synapse; and plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex; frontal cortex; and neocortex region. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 16.9), cortex adult (RPKM 13.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Shank1 in Genome Data Viewer
    Location:
    7 B3; 7 28.83 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43958343..44009518)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44308916..44360094)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7238 Neighboring gene STARR-positive B cell enhancer ABC_E129 Neighboring gene C-type lectin domain family 11, member a Neighboring gene RIKEN cDNA 1700008O03 gene Neighboring gene STARR-seq mESC enhancer starr_18792 Neighboring gene predicted gene, 39001 Neighboring gene synaptotagmin III

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ankyrin repeat binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ankyrin repeat binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ionotropic glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor complex adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables somatostatin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables somatostatin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables structural constituent of postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    enables structural constituent of postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables synaptic receptor adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables synaptic receptor adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables synaptic receptor adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adult behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adult behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of affect IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in determination of affect ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in habituation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of postsynaptic density structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of AMPA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in righting reflex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synapse maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vocalization behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vocalization behavior ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SH3 and multiple ankyrin repeat domains protein 1
    Names
    SH3/ankyrin domain gene 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034115.1NP_001029287.1  SH3 and multiple ankyrin repeat domains protein 1

      See identical proteins and their annotated locations for NP_001029287.1

      Status: VALIDATED

      Source sequence(s)
      AC152939
      Consensus CDS
      CCDS52229.1
      UniProtKB/Swiss-Prot
      D3YZU1
      Related
      ENSMUSP00000103571.2, ENSMUST00000107938.8
      Conserved Domains (8) summary
      PTZ00322
      Location:333468
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd09506
      Location:21002165
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03095
      Location:174392
      PHA03095; ankyrin-like protein; Provisional
      PRK07764
      Location:9471156
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cd17175
      Location:70158
      FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43958343..44009518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540864.5XP_006540927.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006540927.1

      UniProtKB/Swiss-Prot
      D3YZU1
      Conserved Domains (8) summary
      PTZ00322
      Location:333468
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd09506
      Location:21002165
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03095
      Location:174392
      PHA03095; ankyrin-like protein; Provisional
      PRK07764
      Location:9471156
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cd17175
      Location:70158
      FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    2. XM_006540868.5XP_006540931.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X8

      Conserved Domains (7) summary
      PTZ00322
      Location:333468
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA03095
      Location:174392
      PHA03095; ankyrin-like protein; Provisional
      PRK07764
      Location:9471156
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cd17175
      Location:70158
      FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    3. XM_006540867.5XP_006540930.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X7

      Conserved Domains (7) summary
      PTZ00322
      Location:333468
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA03095
      Location:174392
      PHA03095; ankyrin-like protein; Provisional
      PRK07764
      Location:9471156
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cd17175
      Location:70158
      FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    4. XM_036153110.1XP_036009003.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X5

      Conserved Domains (8) summary
      PTZ00322
      Location:333468
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd09506
      Location:20652130
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03095
      Location:174392
      PHA03095; ankyrin-like protein; Provisional
      PRK07764
      Location:9121121
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cd17175
      Location:70158
      FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    5. XM_006540865.5XP_006540928.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X2

      UniProtKB/TrEMBL
      D3YZU4
      Related
      ENSMUSP00000103568.2, ENSMUST00000107935.8
      Conserved Domains (8) summary
      PTZ00322
      Location:333468
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd09506
      Location:20922157
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03095
      Location:174392
      PHA03095; ankyrin-like protein; Provisional
      PRK07764
      Location:9391148
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cd17175
      Location:70158
      FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    6. XM_006540866.5XP_006540929.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X3

      UniProtKB/TrEMBL
      D3YZU5
      Related
      ENSMUSP00000103567.2, ENSMUST00000107934.2
      Conserved Domains (8) summary
      PTZ00322
      Location:333468
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd09506
      Location:20912156
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03095
      Location:174392
      PHA03095; ankyrin-like protein; Provisional
      PRK07764
      Location:9381147
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:652745
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cd17175
      Location:70158
      FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    7. XM_030242576.2XP_030098436.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X4

      Conserved Domains (8) summary
      PTZ00322
      Location:333468
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd09506
      Location:20832148
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03095
      Location:174392
      PHA03095; ankyrin-like protein; Provisional
      PRK07764
      Location:9301139
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:652745
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cd17175
      Location:70158
      FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    8. XM_036153111.1XP_036009004.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X6

      Conserved Domains (8) summary
      PTZ00322
      Location:333468
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd09506
      Location:20562121
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03095
      Location:174392
      PHA03095; ankyrin-like protein; Provisional
      PRK07764
      Location:9031112
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:652745
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cd17175
      Location:70158
      FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    9. XM_030242575.2XP_030098435.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3YZU1
      Conserved Domains (8) summary
      PTZ00322
      Location:333468
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd09506
      Location:21002165
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03095
      Location:174392
      PHA03095; ankyrin-like protein; Provisional
      PRK07764
      Location:9471156
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cd17175
      Location:70158
      FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    10. XM_006540874.3XP_006540937.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X15

      Conserved Domains (3) summary
      cd09506
      Location:14501515
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PRK07764
      Location:297506
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:51104
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    11. XM_006540872.3XP_006540935.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X13

      Conserved Domains (3) summary
      cd09506
      Location:14861551
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PRK07764
      Location:333542
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:47140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    12. XM_030242578.2XP_030098438.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X14

      Conserved Domains (3) summary
      cd09506
      Location:14781543
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PRK07764
      Location:325534
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:47140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    13. XM_006540869.4XP_006540932.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X9

      Conserved Domains (3) summary
      cd09506
      Location:15781643
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PRK07764
      Location:425634
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:179232
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    14. XM_036153113.1XP_036009006.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X12

      Conserved Domains (3) summary
      cd09506
      Location:15291594
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PRK07764
      Location:376585
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:130183
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    15. XM_036153112.1XP_036009005.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X9

      Conserved Domains (3) summary
      cd09506
      Location:15781643
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PRK07764
      Location:425634
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:179232
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    16. XM_006540870.4XP_006540933.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X10

      Conserved Domains (3) summary
      cd09506
      Location:15621627
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PRK07764
      Location:409618
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:150216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    17. XM_006540871.4XP_006540934.3  SH3 and multiple ankyrin repeat domains protein 1 isoform X11

      Conserved Domains (3) summary
      cd09506
      Location:15521617
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PRK07764
      Location:399608
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:113206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    18. XM_006540876.5XP_006540939.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X17

      Conserved Domains (2) summary
      cd09506
      Location:12081273
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PRK07764
      Location:55264
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
    19. XM_006540875.5XP_006540938.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X16

      Conserved Domains (2) summary
      cd09506
      Location:12431308
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PRK07764
      Location:90299
      PRK07764; DNA polymerase III subunits gamma and tau; Validated