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    Zfp59 zinc finger protein 59 [ Mus musculus (house mouse) ]

    Gene ID: 22717, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp59provided by MGI
    Official Full Name
    zinc finger protein 59provided by MGI
    Primary source
    MGI:MGI:99206
    See related
    Ensembl:ENSMUSG00000078779 AllianceGenome:MGI:99206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mfg2; Mfg-2
    Summary
    The Krueppel-associated box (KRAB) is a domain of around 75 amino acids found in the N-terminal portion of about one third of eukaryotic Krueppel-type C2H2 zinc finger proteins (ZFPs). The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. Although the function of KRAB-ZFPs is largely unknown, they appear to play important roles during cell differentiation and development. This gene encodes a protein belonging to the Krueppel family of C2H2-type zinc finger proteins and has been shown to accumulate in the nuclei of mature sperm in association with the nuclear matrix. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in CNS E11.5 (RPKM 2.2), CNS E18 (RPKM 2.2) and 24 other tissues See more
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    Genomic context

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    See Zfp59 in Genome Data Viewer
    Location:
    7 A3; 7 15.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27535471..27556218)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27836046..27856793)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29810 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28589770-28589879 Neighboring gene zinc finger protein 626 Neighboring gene STARR-seq mESC enhancer starr_18392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28645358-28645700 Neighboring gene zinc finger protein 607A Neighboring gene STARR-seq mESC enhancer starr_18395 Neighboring gene protein kinase C, zeta 2 Neighboring gene zinc finger protein 974 Neighboring gene predicted gene, 26891

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The product of Zfp59 (Mfg2), a mouse gene expressed at the spermatid stage of spermatogenesis, accumulates in spermatozoa nuclei. Passananti C, et al. Cell Growth Differ, 1995 Aug. PMID 8547218
    2. Mouse genes coding for "zinc-finger"-containing proteins: characterization and expression in differentiated cells. Passananti C, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2512579, Free PMC Article
    3. Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. Peng H, et al. J Biol Chem, 2000 Jun 16. PMID 10748030
    4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 59
    Names
    zfp-59
    zinc finger protein Mfg-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011762.4 → NP_035892.2  zinc finger protein 59

      See identical proteins and their annotated locations for NP_035892.2

      Status: VALIDATED

      Source sequence(s)
      AC139063, AC164532
      Consensus CDS
      CCDS39851.1
      UniProtKB/Swiss-Prot
      F8VPX4, P16373, Q61849
      Related
      ENSMUSP00000145671.2, ENSMUST00000205701.2
      Conserved Domains (3) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:167 → 554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27535471..27556218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242394.1 → XP_030098254.1  zinc finger protein 59 isoform X1

      UniProtKB/Swiss-Prot
      F8VPX4, P16373, Q61849
      Conserved Domains (3) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:167 → 554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030242396.1 → XP_030098256.1  zinc finger protein 59 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:125 → 512
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 33
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. XM_030242397.2 → XP_030098257.1  zinc finger protein 59 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:93 → 480
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:212 → 232
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16373.3 GenPept UniProtKB/Swiss-Prot:P16373

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