Tchp trichoplein, keratin filament binding [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tchpprovided by MGI
Official Full Name: trichoplein, keratin filament bindingprovided by MGI
Primary source: MGI:MGI:1925082
See related: Ensembl:ENSMUSG00000002486 AllianceGenome:MGI:1925082
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A930031F18Rik
Summary: Predicted to be involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Located in desmosome and keratin filament. Part of ciliary transition fiber. Is expressed in inner ear and olfactory epithelium. Orthologous to human TCHP (trichoplein keratin filament binding). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 22.2), CNS E11.5 (RPKM 10.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.99 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (114845813..114860388)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (114707779..114722327)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.
Title: Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.
MITOSTATIN may acts as a tumor suppressor gene in prostate cancer.
Title: Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical cortex	ISO Inferred from Sequence Orthology more info
located_in apical cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
part_of ciliary transition fiber	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in desmosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IDA Inferred from Direct Assay more info	PubMed
located_in keratin filament	ISO Inferred from Sequence Orthology more info
located_in keratin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: trichoplein keratin filament-binding protein

Names: mitochondrial protein with oncostatic activity; mitostatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029992.2 → NP_084268.2 trichoplein keratin filament-binding protein

See identical proteins and their annotated locations for NP_084268.2

Status: VALIDATED

Source sequence(s)

AK020912, AK159947, BC043048, BU512279

Consensus CDS

CCDS51624.1

UniProtKB/Swiss-Prot

Q3TVW5, Q80ZV6, Q8C459, Q9CTP0

Related

ENSMUSP00000092009.5, ENSMUST00000094441.11

Conserved Domains (1) summary

pfam13868
Location:145 → 479

TPH; Trichohyalin-plectin-homology domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

114845813..114860388

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530508.4 → XP_006530571.1 trichoplein keratin filament-binding protein isoform X1

Conserved Domains (1) summary

pfam13868
Location:83 → 420

TPH; Trichohyalin-plectin-homology domain
XM_036165613.1 → XP_036021506.1 trichoplein keratin filament-binding protein isoform X3

Conserved Domains (1) summary

pfam13868
Location:4 → 223

TPH; Trichohyalin-plectin-homology domain
XM_006530510.5 → XP_006530573.1 trichoplein keratin filament-binding protein isoform X3

See identical proteins and their annotated locations for XP_006530573.1

UniProtKB/Swiss-Prot

Q3TVW5

Conserved Domains (1) summary

pfam13868
Location:4 → 223

TPH; Trichohyalin-plectin-homology domain
XM_006530511.5 → XP_006530574.1 trichoplein keratin filament-binding protein isoform X2

Conserved Domains (1) summary

pfam13868
Location:1 → 282

TPH; Trichohyalin-plectin-homology domain