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    Stpg1 sperm tail PG rich repeat containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 78806, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Stpg1provided by MGI
    Official Full Name
    sperm tail PG rich repeat containing 1provided by MGI
    Primary source
    MGI:MGI:1926056
    See related
    Ensembl:ENSMUSG00000028801 AllianceGenome:MGI:1926056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mapo2; 4930403G18Rik; 4930555I21Rik
    Summary
    Predicted to be involved in positive regulation of apoptotic process and positive regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to be located in mitochondrion and nucleus. Orthologous to human STPG1 (sperm tail PG-rich repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 36.0) See more
    Orthologs
    human all
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    Genomic context

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    See Stpg1 in Genome Data Viewer
    Location:
    4 D3; 4 67.7 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135221971..135265015)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135494670..135537803)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene noncompact myelin associated protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134982608-134982761 Neighboring gene regulator of calcineurin 3 Neighboring gene microRNA 700 Neighboring gene STARR-positive B cell enhancer ABC_E9603 Neighboring gene STARR-positive B cell enhancer ABC_E1286 Neighboring gene NIPA-like domain containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:135050361-135050662 Neighboring gene STARR-seq mESC enhancer starr_11721 Neighboring gene STARR-seq mESC enhancer starr_11724 Neighboring gene grainyhead like transcription factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E6235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135126769-135126952 Neighboring gene STARR-seq mESC enhancer starr_11727 Neighboring gene predicted gene, 30888 Neighboring gene STARR-seq mESC enhancer starr_11728 Neighboring gene STARR-seq mESC enhancer starr_11730 Neighboring gene RIKEN cDNA 1700029M20 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine. Fujikane R, et al. PLoS One, 2012. PMID 23028632, Free PMC Article
    2. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Osipovich AB, et al. Genome Res, 2005 Mar. PMID 15741512, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAPO2 gene product might positively contribute to the induction of apoptosis triggered by O-methylguanine
      Title: The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    O(6)-methylguanine-induced apoptosis 2
    Names
    O6-methylguanine-induced apoptosis 2
    UPF0490 protein C1orf201 homolog
    sperm-tail PG-rich repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419281.1 → NP_001406210.1  O(6)-methylguanine-induced apoptosis 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL670720
      UniProtKB/Swiss-Prot
      Q9D2F5

    2. NM_001419282.1 → NP_001406211.1  O(6)-methylguanine-induced apoptosis 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL670720

    3. NM_001419286.1 → NP_001406215.1  O(6)-methylguanine-induced apoptosis 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL670720

    4. NM_001419287.1 → NP_001406216.1  O(6)-methylguanine-induced apoptosis 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL670720

    5. NM_030189.4 → NP_084465.1  O(6)-methylguanine-induced apoptosis 2 isoform a

      See identical proteins and their annotated locations for NP_084465.1

      Status: VALIDATED

      Source sequence(s)
      AL670720
      Consensus CDS
      CCDS18787.1
      UniProtKB/Swiss-Prot
      Q9D2F5
      UniProtKB/TrEMBL
      A6H5V9
      Related
      ENSMUSP00000067647.3, ENSMUST00000063707.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135221971..135265015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320458.3 → XP_017175947.1  O(6)-methylguanine-induced apoptosis 2 isoform X5

    2. XM_017320457.3 → XP_017175946.1  O(6)-methylguanine-induced apoptosis 2 isoform X4

      UniProtKB/TrEMBL
      A6H5V9

    3. XM_006539286.5 → XP_006539349.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

      See identical proteins and their annotated locations for XP_006539349.1

      UniProtKB/Swiss-Prot
      Q9D2F5
      UniProtKB/TrEMBL
      A6H5V9

    4. XM_006539285.4 → XP_006539348.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

      See identical proteins and their annotated locations for XP_006539348.1

      UniProtKB/Swiss-Prot
      Q9D2F5
      UniProtKB/TrEMBL
      A6H5V9

    5. XM_006539287.4 → XP_006539350.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

      See identical proteins and their annotated locations for XP_006539350.1

      UniProtKB/Swiss-Prot
      Q9D2F5
      UniProtKB/TrEMBL
      A6H5V9

    6. XM_011250356.3 → XP_011248658.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

      See identical proteins and their annotated locations for XP_011248658.1

      UniProtKB/Swiss-Prot
      Q9D2F5
      UniProtKB/TrEMBL
      A6H5V9

    7. XM_006539288.2 → XP_006539351.1  O(6)-methylguanine-induced apoptosis 2 isoform X2

      UniProtKB/TrEMBL
      A6H5V9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2F5.1 GenPept UniProtKB/Swiss-Prot:Q9D2F5

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