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    Lrig2 leucine-rich repeats and immunoglobulin-like domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 269473, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrig2provided by MGI
    Official Full Name
    leucine-rich repeats and immunoglobulin-like domains 2provided by MGI
    Primary source
    MGI:MGI:2443718
    See related
    Ensembl:ENSMUSG00000032913 AllianceGenome:MGI:2443718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LIG-2; 4632419I10Rik
    Summary
    Enables signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of axon regeneration; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of protein localization to cell surface. Located in growth cone; intracellular vesicle; and membrane. Is expressed in several structures, including branchial arch; central nervous system; eye; inner ear; and nasal pit. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human LRIG2 (leucine rich repeats and immunoglobulin like domains 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.1), whole brain E14.5 (RPKM 6.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrig2 in Genome Data Viewer
    Location:
    3 F2.2; 3 45.62 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104361296..104419251, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104453980..104511918, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5546 Neighboring gene STARR-seq mESC enhancer starr_08609 Neighboring gene STARR-seq mESC enhancer starr_08610 Neighboring gene predicted gene, 38412 Neighboring gene STARR-seq mESC enhancer starr_08611 Neighboring gene phosducin-like 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4569 Neighboring gene STARR-seq mESC enhancer starr_08613 Neighboring gene STARR-seq mESC enhancer starr_08614 Neighboring gene STARR-seq mESC enhancer starr_08615 Neighboring gene STARR-seq mESC enhancer starr_08617 Neighboring gene STARR-positive B cell enhancer ABC_E4570 Neighboring gene VISTA enhancer mm1537 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104369426-104369609 Neighboring gene predicted gene, 34490 Neighboring gene predicted gene, 54213

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma. Li ZQ, et al. BMC Cancer, 2022 Oct 1. PMID 36183058, Free PMC Article
    2. Lrig2-deficient mice are protected against PDGFB-induced glioma. Rondahl V, et al. PLoS One, 2013. PMID 24023893, Free PMC Article
    3. Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder. Roberts NA, et al. Kidney Int, 2019 May. PMID 30885509, Free PMC Article
    4. Urinary tract effects of HPSE2 mutations. Stuart HM, et al. J Am Soc Nephrol, 2015 Apr. PMID 25145936, Free PMC Article
    5. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. Del Rio T, et al. PLoS Genet, 2013. PMID 24086156, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma.
      Title: LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma.
    2. Mice with homozygous mutations in either Lrig2 or Hpse2 had increased nerve density within the urinary bladder body and decreased nerve density around the urinary outflow tract. Observations provide evidence that a peripheral neuropathy is central to the pathobiology of functional bladder outlet obstruction in urofacial syndrome and emphasize the importance of LRIG2 and Hpse2 for nerve patterning in the urinary tract.
      Title: Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.
    3. Lrig2 has a role in negative regulation of ectodomain shedding of axon guidance receptors by ADAM17 protease
      Title: Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
    4. phenotype of Lrig2E12-/- mice showed that Lrig2 was a promoter of PDGFB-induced glioma
      Title: Lrig2-deficient mice are protected against PDGFB-induced glioma.
    5. At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia
      Title: In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within innervation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of membrane protein ectodomain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of membrane protein ectodomain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of platelet-derived growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeats and immunoglobulin-like domains protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025067.2 → NP_001020238.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001020238.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC094228, BY205369, CN532345
      Consensus CDS
      CCDS17701.1
      UniProtKB/Swiss-Prot
      Q52KR2, Q69ZY8
      Related
      ENSMUSP00000035999.7, ENSMUST00000046316.11
      Conserved Domains (10) summary
      cd05763
      Location:618 → 692
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00082
      Location:444 → 492
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:503 → 597
      IG_like; Immunoglobulin like
      cd00116
      Location:16 → 204
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:601 → 691
      I-set; Immunoglobulin I-set domain
      sd00031
      Location:53 → 75
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:145 → 167
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:385 → 426
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:311 → 370
      LRR_8; Leucine rich repeat
      cl11960
      Location:713 → 782
      Ig; Immunoglobulin domain

    2. NM_001310698.1 → NP_001297627.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001297627.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in its 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK036116, BC094228, BY205369, CK636907, CN532345
      Consensus CDS
      CCDS79993.1
      UniProtKB/TrEMBL
      B2RRI5
      Related
      ENSMUSP00000142540.2, ENSMUST00000198332.2
      Conserved Domains (10) summary
      cd05763
      Location:618 → 692
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00082
      Location:444 → 492
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:503 → 597
      IG_like; Immunoglobulin like
      cd00116
      Location:16 → 204
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:601 → 691
      I-set; Immunoglobulin I-set domain
      sd00031
      Location:53 → 75
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:145 → 167
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:385 → 426
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:311 → 370
      LRR_8; Leucine rich repeat
      cl11960
      Location:713 → 782
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104361296..104419251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319602.3 → XP_017175091.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X3

      Related
      ENSMUSP00000142373.2, ENSMUST00000199070.5
      Conserved Domains (4) summary
      cd05763
      Location:200 → 274
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00082
      Location:26 → 74
      LRRCT; Leucine rich repeat C-terminal domain
      pfam07679
      Location:277 → 364
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:83 → 179
      Ig; Immunoglobulin domain

    2. XM_036163127.1 → XP_036019020.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1

      Conserved Domains (10) summary
      TIGR00864
      Location:367 → 444
      PCC; polycystin cation channel protein
      sd00031
      Location:53 → 75
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:145 → 167
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07679
      Location:647 → 734
      I-set; Immunoglobulin I-set domain
      pfam13855
      Location:338 → 389
      LRR_8; Leucine rich repeat
      pfam13927
      Location:448 → 535
      Ig_3; Immunoglobulin domain
      cd00096
      Location:655 → 658
      Ig; Ig strand A' [structural motif]
      cd05763
      Location:554 → 644
      IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains
      cd21340
      Location:171 → 349
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl39015
      Location:16 → 204
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. XM_006501544.4 → XP_006501607.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2

      Conserved Domains (4) summary
      cd05763
      Location:200 → 274
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00082
      Location:26 → 74
      LRRCT; Leucine rich repeat C-terminal domain
      pfam07679
      Location:277 → 364
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:83 → 179
      Ig; Immunoglobulin domain

    4. XM_030252634.2 → XP_030108494.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X4

      Conserved Domains (3) summary
      cd05763
      Location:91 → 165
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      pfam07679
      Location:168 → 255
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:5 → 70
      Ig; Immunoglobulin domain

    RNA

    1. XR_004941331.1 RNA Sequence

    2. XR_004941330.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q52KR2.1 GenPept UniProtKB/Swiss-Prot:Q52KR2

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