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    Slc27a3 solute carrier family 27 (fatty acid transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 26568, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc27a3provided by MGI
    Official Full Name
    solute carrier family 27 (fatty acid transporter), member 3provided by MGI
    Primary source
    MGI:MGI:1347358
    See related
    Ensembl:ENSMUSG00000027932 AllianceGenome:MGI:1347358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FATP3; Acsvl3; FATP-3; Vlcs-3
    Summary
    Enables fatty-acyl-CoA synthase activity. Predicted to be involved in fatty acid transport and long-chain fatty acid metabolic process. Predicted to act upstream of or within acyl-CoA metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human SLC27A3 (solute carrier family 27 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in adrenal adult (RPKM 148.3), ovary adult (RPKM 32.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Slc27a3 in Genome Data Viewer
    Location:
    3 F1; 3 39.22 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90292540..90298693, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90385230..90390835, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 4B Neighboring gene microRNA 7012 Neighboring gene STARR-positive B cell enhancer ABC_E28 Neighboring gene GATA zinc finger domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_08281 Neighboring gene STARR-positive B cell enhancer ABC_E9009 Neighboring gene STARR-seq mESC enhancer starr_08284 Neighboring gene integrator complex subunit 3 Neighboring gene STARR-seq mESC enhancer starr_08286 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90237240-90237349 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90237716-90237903 Neighboring gene STARR-seq mESC enhancer starr_08287 Neighboring gene STARR-seq mESC enhancer starr_08288 Neighboring gene STARR-positive B cell enhancer ABC_E6072 Neighboring gene STARR-positive B cell enhancer ABC_E56 Neighboring gene natriuretic peptide receptor 1 Neighboring gene nuclear encoded tRNA methionine 11 (anticodon CAT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables arachidonate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty-acyl-CoA synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables very long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables very long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables very long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    long-chain fatty acid transport protein 3
    Names
    arachidonate--CoA ligase
    long-chain-fatty-acid--CoA ligase
    mFLJ00207 protein
    solute carrier family 27 member 3
    very long-chain acyl-CoA synthetase homolog 3
    NP_001303617.1
    NP_036118.2
    XP_011238431.1
    XP_011238432.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316688.2NP_001303617.1  long-chain fatty acid transport protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC145082
      UniProtKB/TrEMBL
      F7CPA3
      Related
      ENSMUSP00000122599.2, ENSMUST00000132041.2
      Conserved Domains (1) summary
      cl17068
      Location:64528
      AFD_class_I; Adenylate forming domain, Class I superfamily
    2. NM_011988.4NP_036118.2  long-chain fatty acid transport protein 3 isoform 1

      See identical proteins and their annotated locations for NP_036118.2

      Status: VALIDATED

      Source sequence(s)
      AC145082
      Consensus CDS
      CCDS17527.1
      UniProtKB/Swiss-Prot
      O88561, Q6PAU1, Q8BK70
      UniProtKB/TrEMBL
      B2RUG3, G3X8Y7
      Related
      ENSMUSP00000029541.6, ENSMUST00000029541.12
      Conserved Domains (2) summary
      PRK08279
      Location:62666
      PRK08279; long-chain-acyl-CoA synthetase; Validated
      cl17068
      Location:88657
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      90292540..90298693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240129.4XP_011238431.1  long-chain fatty acid transport protein 3 isoform X1

      UniProtKB/Swiss-Prot
      O88561, Q6PAU1, Q8BK70
      UniProtKB/TrEMBL
      B2RUG3
      Conserved Domains (1) summary
      cl17068
      Location:87609
      AFD_class_I; Adenylate forming domain, Class I superfamily
    2. XM_011240130.3XP_011238432.1  long-chain fatty acid transport protein 3 isoform X2

      Conserved Domains (1) summary
      cl17068
      Location:37480
      AFD_class_I; Adenylate forming domain, Class I superfamily