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    Nup160 nucleoporin 160 [ Mus musculus (house mouse) ]

    Gene ID: 59015, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nup160provided by MGI
    Official Full Name
    nucleoporin 160provided by MGI
    Primary source
    MGI:MGI:1926227
    See related
    Ensembl:ENSMUSG00000051329 AllianceGenome:MGI:1926227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtl13; 160kDa; Gtl-13; Gtl1-13; mKIAA0197; 2810011M03Rik
    Summary
    A structural constituent of nuclear pore. Involved in mRNA export from nucleus. Part of nuclear pore. Human ortholog(s) of this gene implicated in nephrotic syndrome type 19. Orthologous to human NUP160 (nucleoporin 160). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 4.4), CNS E11.5 (RPKM 4.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nup160 in Genome Data Viewer
    Location:
    2 E1; 2 50.32 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90504405..90570217)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90677215..90739327)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5942 Neighboring gene predicted gene, 39870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90481961-90482070 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90490258-90490559 Neighboring gene predicted gene, 39871 Neighboring gene STARR-positive B cell enhancer ABC_E7838 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90519352-90519653 Neighboring gene STARR-seq mESC enhancer starr_05093 Neighboring gene STARR-seq mESC enhancer starr_05095 Neighboring gene predicted gene, 39872 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90585318-90585501 Neighboring gene ribosomal protein L30, pseudogene 3 Neighboring gene formin binding protein 4 Neighboring gene ATP/GTP binding protein-like 2 Neighboring gene predicted gene 13772

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy. Xie J, et al. Bioengineered, 2021 Dec. PMID 34533106, Free PMC Article
    2. Knockdown of NUP160 inhibits cell proliferation, induces apoptosis, autophagy and cell migration, and alters the expression and localization of podocyte associated molecules in mouse podocytes. Wang P, et al. Gene, 2018 Jul 20. PMID 29704630
    3. Podocyte-specific Nup160 knockout mice develop nephrotic syndrome and glomerulosclerosis. Li Y, et al. Hum Mol Genet, 2024 Apr 8. PMID 38224683
    4. Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death. Sakuma S, et al. Cancer Discov, 2021 Jan. PMID 32988961, Free PMC Article
    5. Dynamics of Lamins B and A/C and Nucleoporin Nup160 during Meiotic Maturation in Mouse Oocytes. Nikolova V, et al. Folia Biol (Praha), 2017. PMID 28374669

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Podocyte-specific Nup160 knockout mice develop nephrotic syndrome and glomerulosclerosis.
      Title: Podocyte-specific Nup160 knockout mice develop nephrotic syndrome and glomerulosclerosis.
    2. Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy.
      Title: Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy.
    3. Knockdown of NUP160 impairs mouse podocytes, i.e. inhibiting cell proliferation, inducing apoptosis, autophagy and cell migration of mouse podocytes, and altering the expression and localization of podocyte associated molecules
      Title: Knockdown of NUP160 inhibits cell proliferation, induces apoptosis, autophagy and cell migration, and alters the expression and localization of podocyte associated molecules in mouse podocytes.
    4. While the distribution patterns of both lamins closely paralleled the respective stages of mitosis, Nup160 localization in metaphase oocytes corresponded to that in mitotic prometaphase rather than metaphase.
      Title: Dynamics of Lamins B and A/C and Nucleoporin Nup160 during Meiotic Maturation in Mouse Oocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0197

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nephron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of nuclear pore outer ring ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore outer ring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup160
    Names
    160 kDa nucleoporin
    gene trap locus 1-13 protein
    gene trap locus-13
    nucleoporin 160kDa
    nucleoporin Nup160

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418509.1 → NP_001405438.1  nuclear pore complex protein Nup160 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL714026, AL935132

    2. NM_001418510.1 → NP_001405439.1  nuclear pore complex protein Nup160 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL935132

    3. NM_001418511.1 → NP_001405440.1  nuclear pore complex protein Nup160 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL714026

    4. NM_021512.3 → NP_067487.1  nuclear pore complex protein Nup160 isoform 1

      See identical proteins and their annotated locations for NP_067487.1

      Status: VALIDATED

      Source sequence(s)
      AL714026, AL935132
      Consensus CDS
      CCDS16413.1
      UniProtKB/Swiss-Prot
      Q3TBI7, Q3TP11, Q3U250, Q6A0A7, Q7TME1, Q9CZD9, Q9Z0W3
      Related
      ENSMUSP00000059289.7, ENSMUST00000057481.7
      Conserved Domains (1) summary
      pfam11715
      Location:28 → 543
      Nup160; Nucleoporin Nup120/160

    RNA

    1. NR_184761.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL714026, AL935132

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      90504405..90570217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499968.5 → XP_006500031.1  nuclear pore complex protein Nup160 isoform X1

      See identical proteins and their annotated locations for XP_006500031.1

      UniProtKB/Swiss-Prot
      Q3TBI7, Q3TP11, Q3U250, Q6A0A7, Q7TME1, Q9CZD9, Q9Z0W3
      Conserved Domains (1) summary
      pfam11715
      Location:28 → 543
      Nup160; Nucleoporin Nup120/160

    2. XM_030251919.2 → XP_030107779.1  nuclear pore complex protein Nup160 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0W3.2 GenPept UniProtKB/Swiss-Prot:Q9Z0W3

    Gene LinkOut

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