Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnh7provided by MGI
Official Full Name: potassium voltage-gated channel, subfamily H (eag-related), member 7provided by MGI
Primary source: MGI:MGI:2159566
See related: Ensembl:ENSMUSG00000059742 AllianceGenome:MGI:2159566
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: erg3; Kv11.3; 9330137I11Rik
Summary: Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including heart; nervous system; retina; skeletal muscle; and skin. Orthologous to human KCNH7 (potassium voltage-gated channel subfamily H member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 1.9), frontal lobe adult (RPKM 1.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.3; 2 36.5 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (62524428..63014980, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (62693410..63184287, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-a-go-go-related gene) K[+] channel subunits.
Title: Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go-related gene) K(+) channel subunits.
Low ERG3 expression is associated with epilepsy.
Title: ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice.
Egr3 has an essential role in regulating cortical arousal, wakefulness, and sleep, presumably by its regulation of 5-HT2 receptors.
Title: Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT(2) Deficits.
ERG3 K+ channels contribute to threshold excitability of mouse auditory brainstem neurons.
Title: Ether-à-go-go-related gene K+ channels contribute to threshold excitability of mouse auditory brainstem neurons.
erg3 gene expression pattern in the developing embryo.
Title: Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-gated inwardly rectifying potassium channel KCNH7; potassium voltage-gated channel subfamily H member 7

Names: ERG-3; eag-related protein 3; ether-a-go-go-related gene potassium channel 3; ether-a-go-go-related protein 3; potassium channel protein erg3; voltage-gated potassium channel subunit Kv11.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133207.2 → NP_573470.2 voltage-gated inwardly rectifying potassium channel KCNH7

See identical proteins and their annotated locations for NP_573470.2

Status: VALIDATED

Source sequence(s)

AL928663, AL928689, AL929246

Consensus CDS

CCDS38128.1

UniProtKB/Swiss-Prot

A2AUY8, Q9ER47

Related

ENSMUSP00000074563.4, ENSMUST00000075052.10

Conserved Domains (6) summary

COG0664
Location:739 → 869

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:745 → 856

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:41 → 130

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:448 → 671

Ion_trans; Ion transport protein

pfam07885
Location:614 → 668

Ion_trans_2; Ion channel

pfam13426
Location:29 → 134

PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

62524428..63014980 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239315.4 → XP_011237617.1 potassium voltage-gated channel subfamily H member 7 isoform X5

Conserved Domains (3) summary

cd00038
Location:739 → 850

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:402 → 664

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_036158885.1 → XP_036014778.1 potassium voltage-gated channel subfamily H member 7 isoform X4

Conserved Domains (3) summary

cd00038
Location:743 → 854

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:410 → 672

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_011239314.4 → XP_011237616.1 potassium voltage-gated channel subfamily H member 7 isoform X3

Conserved Domains (3) summary

cd00038
Location:747 → 858

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:410 → 672

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_017315931.3 → XP_017171420.1 potassium voltage-gated channel subfamily H member 7 isoform X6

Conserved Domains (3) summary

cd00038
Location:612 → 723

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:388 → 537

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_006498825.4 → XP_006498888.1 potassium voltage-gated channel subfamily H member 7 isoform X2

Conserved Domains (3) summary

cd00038
Location:750 → 861

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:417 → 679

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_011239313.4 → XP_011237615.1 potassium voltage-gated channel subfamily H member 7 isoform X1

Conserved Domains (3) summary

cd00038
Location:753 → 864

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:417 → 679

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_011239317.4 → XP_011237619.1 potassium voltage-gated channel subfamily H member 7 isoform X13

Conserved Domains (2) summary

cd00038
Location:241 → 352

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:7 → 166

Ion_trans; Ion transport protein
XM_036158888.1 → XP_036014781.1 potassium voltage-gated channel subfamily H member 7 isoform X8

Conserved Domains (1) summary

PLN03192
Location:47 → 520

PLN03192; Voltage-dependent potassium channel; Provisional
XM_017315932.2 → XP_017171421.1 potassium voltage-gated channel subfamily H member 7 isoform X7

Conserved Domains (3) summary

cd00038
Location:754 → 865

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:417 → 679

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_006498828.2 → XP_006498891.1 potassium voltage-gated channel subfamily H member 7 isoform X11

Conserved Domains (2) summary

pfam00520
Location:402 → 664

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_017315936.3 → XP_017171425.1 potassium voltage-gated channel subfamily H member 7 isoform X12

Conserved Domains (2) summary

pfam00520
Location:409 → 671

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_030247906.2 → XP_030103766.1 potassium voltage-gated channel subfamily H member 7 isoform X14

UniProtKB/TrEMBL

Q8CC38

Related

ENSMUSP00000108073.2, ENSMUST00000112454.8

Conserved Domains (2) summary

pfam00520
Location:417 → 579

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_006498826.2 → XP_006498889.1 potassium voltage-gated channel subfamily H member 7 isoform X9

Conserved Domains (2) summary

pfam00520
Location:417 → 679

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain
XM_006498827.2 → XP_006498890.1 potassium voltage-gated channel subfamily H member 7 isoform X10

Conserved Domains (2) summary

pfam00520
Location:417 → 679

Ion_trans; Ion transport protein

pfam13426
Location:29 → 134

PAS_9; PAS domain