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    Ggta1 glycoprotein galactosyltransferase alpha 1, 3 [ Mus musculus (house mouse) ]

    Gene ID: 14594, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ggta1provided by MGI
    Official Full Name
    glycoprotein galactosyltransferase alpha 1, 3provided by MGI
    Primary source
    MGI:MGI:95704
    See related
    Ensembl:ENSMUSG00000035778 AllianceGenome:MGI:95704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gal; GALT; Ggta; Ggta-1; alpha Gal; alpha3GalT
    Summary
    This gene encodes a member of the galactosyltransferase family of intracellular, membrane-bound enzymes that are involved in the biosynthesis of glycoproteins and glycolipids. The encoded protein catalyzes the transfer of galactose from UDP-galactose to N-acetyllactosamine in an alpha(1,3) linkage to form galactose alpha(1,3)-galactose. Mice lacking the encoded protein develop cortical cataracts. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 6.2), lung adult (RPKM 5.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ggta1 in Genome Data Viewer
    Location:
    2 B; 2 23.6 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (35290191..35354393, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35400179..35464381, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930568D16 gene Neighboring gene RIKEN cDNA 4930402F06 gene Neighboring gene predicted gene, 39797 Neighboring gene STARR-positive B cell enhancer ABC_E9510 Neighboring gene STARR-positive B cell enhancer mm9_chr2:35316734-35317035 Neighboring gene STARR-positive B cell enhancer ABC_E2034 Neighboring gene transmembrane emp24 protein transport domain containing 9 pseudogene Neighboring gene predicted gene 13445

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vivo T-cell depletion enhances production of anti-GALalpha1,3GAL natural antibodies in alpha1,3-galactosyltransferase-deficient mice. Ohdan H, et al. Transplantation, 2000 Mar 15. PMID 10755549
    2. Cutting Edge: NK cells mediate IgG1-dependent hyperacute rejection of xenografts. Yin D, et al. J Immunol, 2004 Jun 15. PMID 15187097
    3. Suppression of Lewis lung tumor development in alpha 1,3 galactosyltransferase knock-out mice. Posekany KJ, et al. Anticancer Res, 2004 Mar-Apr. PMID 15161001
    4. Mouse-heart grafts expressing an incompatible carbohydrate antigen. II. Transition from accommodation to tolerance. Ogawa H, et al. Transplantation, 2004 Feb 15. PMID 14966409
    5. Tolerance induction to a mammalian blood group-like carbohydrate antigen by syngeneic lymphocytes expressing the antigen. Ogawa H, et al. Blood, 2003 Mar 15. PMID 12406874

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report immune responses and calcification in bovine/porcine heart valves implanted in alpha1,3-galactosyltransferase knockout mice.
      Title: The Immune Responses and Calcification of Bioprostheses in the α1,3-Galactosyltransferase Knockout Mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyllactosaminide alpha-1,3-galactosyltransferase
    Names
    UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase
    glycoprotein alpha galactosyl transferase 1
    NP_001139293.1
    NP_001295228.1
    NP_001295229.1
    NP_001407194.1
    NP_001407195.1
    NP_001407196.1
    NP_001407197.1
    NP_001407198.1
    NP_001407199.1
    NP_001407200.1
    NP_001407201.1
    NP_001407202.1
    NP_001407206.1
    NP_001407207.1
    NP_034413.2
    XP_011237329.1
    XP_011237330.1
    XP_011237331.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145821.3 → NP_001139293.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001139293.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 7 both encode the same isoform (2).
      Source sequence(s)
      AL929076, AL929199
      Consensus CDS
      CCDS50576.1
      UniProtKB/Swiss-Prot
      P23336, Q91V22
      UniProtKB/TrEMBL
      Q3TXW0
      Related
      ENSMUSP00000108626.3, ENSMUST00000113002.9
      Conserved Domains (1) summary
      pfam03414
      Location:71 → 392
      Glyco_transf_6; Glycosyltransferase family 6

    2. NM_001308299.2 → NP_001295228.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 3

      See identical proteins and their annotated locations for NP_001295228.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AL929076, AL929199
      Consensus CDS
      CCDS79787.1
      UniProtKB/TrEMBL
      A2AUR0, Q8C2H7
      Related
      ENSMUSP00000108625.3, ENSMUST00000113001.9
      Conserved Domains (1) summary
      pfam03414
      Location:81 → 382
      Glyco_transf_6; Glycosyltransferase family 6

    3. NM_001308300.2 → NP_001295229.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 4

      See identical proteins and their annotated locations for NP_001295229.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Variants 4 and 8 both encode the same isoform (4).
      Source sequence(s)
      AL929076, AL929199
      Consensus CDS
      CCDS79786.1
      UniProtKB/TrEMBL
      Q91W00
      Related
      ENSMUSP00000078393.5, ENSMUST00000079424.11
      Conserved Domains (1) summary
      pfam03414
      Location:69 → 370
      Glyco_transf_6; Glycosyltransferase family 6

    4. NM_001420265.1 → NP_001407194.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 5, and 6 all encode the same isoform (1).
      Source sequence(s)
      AL929076, AL929199
      UniProtKB/TrEMBL
      Q9DBU1

    5. NM_001420266.1 → NP_001407195.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 5, and 6 all encode the same isoform (1).
      Source sequence(s)
      AL929199
      UniProtKB/TrEMBL
      Q9DBU1
      Related
      ENSMUSP00000049408.7, ENSMUST00000044255.13

    6. NM_001420267.1 → NP_001407196.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 2. Variants 2 and 7 both encode the same isoform (2).
      Source sequence(s)
      AL929076, AL929199
      UniProtKB/Swiss-Prot
      P23336, Q91V22
      UniProtKB/TrEMBL
      Q3TXW0

    7. NM_001420268.1 → NP_001407197.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 4. Variants 4 and 8 both encode the same isoform (4).
      Source sequence(s)
      AL929076, AL929199
      UniProtKB/TrEMBL
      Q91W00

    8. NM_001420269.1 → NP_001407198.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL929076, AL929199

    9. NM_001420270.1 → NP_001407199.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL929076, AL929199

    10. NM_001420271.1 → NP_001407200.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL929076, AL929199

    11. NM_001420272.1 → NP_001407201.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL929076, AL929199

    12. NM_001420273.1 → NP_001407202.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL929076, AL929199

    13. NM_001420277.1 → NP_001407206.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL929076, AL929199

    14. NM_001420278.1 → NP_001407207.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL929076, AL929199

    15. NM_010283.5 → NP_034413.2  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1

      See identical proteins and their annotated locations for NP_034413.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 5, and 6 all encode the same isoform (1).
      Source sequence(s)
      AL929076, AL929199
      Consensus CDS
      CCDS15964.2
      UniProtKB/TrEMBL
      Q9DBU1
      Related
      ENSMUSP00000099858.2, ENSMUST00000102794.8
      Conserved Domains (1) summary
      pfam03414
      Location:83 → 404
      Glyco_transf_6; Glycosyltransferase family 6

    RNA

    1. NR_185155.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL929076, AL929199

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      35290191..35354393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239029.2 → XP_011237331.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011237331.1

      UniProtKB/TrEMBL
      Q9DBU1
      Conserved Domains (1) summary
      pfam03414
      Location:83 → 404
      Glyco_transf_6; Glycosyltransferase family 6

    2. XM_011239027.3 → XP_011237329.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011237329.1

      UniProtKB/TrEMBL
      Q9DBU1
      Conserved Domains (1) summary
      pfam03414
      Location:83 → 404
      Glyco_transf_6; Glycosyltransferase family 6

    3. XM_011239028.4 → XP_011237330.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011237330.1

      UniProtKB/TrEMBL
      Q9DBU1
      Conserved Domains (1) summary
      pfam03414
      Location:83 → 404
      Glyco_transf_6; Glycosyltransferase family 6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23336.1 GenPept UniProtKB/Swiss-Prot:P23336

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