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    Spaca6 sperm acrosome associated 6 [ Mus musculus (house mouse) ]

    Gene ID: 75202, updated on 27-Nov-2024

    Summary

    Official Symbol
    Spaca6provided by MGI
    Official Full Name
    sperm acrosome associated 6provided by MGI
    Primary source
    MGI:MGI:1922452
    See related
    Ensembl:ENSMUSG00000080316 AllianceGenome:MGI:1922452
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    let-7e; SPACA6A; mir-99b; mir-125a; Ncrna00085; 4930546H06Rik; 9530079D04Rik; B230206P06Rik
    Summary
    Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Located in acrosomal vesicle. Orthologous to human SPACA6 (sperm acrosome associated 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.5), limb E14.5 (RPKM 5.9) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Spaca6 in Genome Data Viewer
    Location:
    17 A3.2; 17 10.5 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (18045955..18063274)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (17826085..17843010)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene vomeronasal 2, receptor 90 Neighboring gene STARR-seq mESC enhancer starr_41964 Neighboring gene STARR-seq mESC enhancer starr_41965 Neighboring gene STARR-seq mESC enhancer starr_41966 Neighboring gene STARR-seq mESC enhancer starr_41967 Neighboring gene STARR-seq mESC enhancer starr_41968 Neighboring gene microRNA let7e Neighboring gene microRNA 125a Neighboring gene microRNA 99b Neighboring gene predicted gene, 36907 Neighboring gene hyaluronan synthase 1 Neighboring gene formyl peptide receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General protein information

    Preferred Names
    sperm acrosome membrane-associated protein 6
    Names
    immunoglobulin domain-containing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162909.1NP_001156381.1  sperm acrosome membrane-associated protein 6 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AC165361
      Consensus CDS
      CCDS49967.1
      UniProtKB/Swiss-Prot
      B7ZWC7, D3Z1S3, E9Q8Q8, J3QMI7
      Related
      ENSMUSP00000128732.3, ENSMUST00000172097.9
      Conserved Domains (2) summary
      smart00410
      Location:172242
      IG_like; Immunoglobulin like
      cl11960
      Location:175245
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      18045955..18063274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246692.4XP_011244994.1  sperm acrosome membrane-associated protein 6 isoform X7

    2. XM_017317705.3XP_017173194.1  sperm acrosome membrane-associated protein 6 isoform X9

      Conserved Domains (1) summary
      pfam12101
      Location:5878
      DUF3577; Protein of unknown function (DUF3577)
    3. XM_006525053.4XP_006525116.1  sperm acrosome membrane-associated protein 6 isoform X1

    4. XM_036160818.1XP_036016711.1  sperm acrosome membrane-associated protein 6 isoform X2

    5. XM_006525055.5XP_006525118.1  sperm acrosome membrane-associated protein 6 isoform X3

      Conserved Domains (1) summary
      cl09930
      Location:1270
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    6. XM_036160819.1XP_036016712.1  sperm acrosome membrane-associated protein 6 isoform X5

    7. XM_006525056.5XP_006525119.1  sperm acrosome membrane-associated protein 6 isoform X4

    8. XM_030250121.2XP_030105981.1  sperm acrosome membrane-associated protein 6 isoform X6

    9. XM_011246695.4XP_011244997.1  sperm acrosome membrane-associated protein 6 isoform X8

      See identical proteins and their annotated locations for XP_011244997.1

      Conserved Domains (1) summary
      pfam12101
      Location:5878
      DUF3577; Protein of unknown function (DUF3577)

    RNA

    1. XR_385379.5 RNA Sequence

    2. XR_876567.4 RNA Sequence

    3. XR_876568.4 RNA Sequence

    4. XR_876572.4 RNA Sequence

    5. XR_003952208.2 RNA Sequence

    6. XR_385377.4 RNA Sequence

    7. XR_003952205.2 RNA Sequence

    8. XR_876569.4 RNA Sequence

    9. XR_385378.5 RNA Sequence

    10. XR_004939594.1 RNA Sequence

    11. XR_003952206.2 RNA Sequence

    12. XR_004939595.1 RNA Sequence

    13. XR_004939596.1 RNA Sequence

    14. XR_004939593.1 RNA Sequence

    15. XR_003952207.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029205.2: Suppressed sequence

      Description
      NM_029205.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.