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    Telo2 telomere maintenance 2 [ Mus musculus (house mouse) ]

    Gene ID: 71718, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Telo2provided by MGI
    Official Full Name
    telomere maintenance 2provided by MGI
    Primary source
    MGI:MGI:1918968
    See related
    Ensembl:ENSMUSG00000024170 AllianceGenome:MGI:1918968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tel2; mKIAA0683; 1200003M09Rik
    Summary
    Enables molecular adaptor activity. Involved in protein stabilization. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of TTT Hsp90 cochaperone complex. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human TELO2 (telomere maintenance 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.6), limb E14.5 (RPKM 9.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Telo2 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25318543..25334951, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25099569..25115974, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cramped chromatin regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E396 Neighboring gene intraflagellar transport 140 Neighboring gene STARR-positive B cell enhancer ABC_E11631 Neighboring gene transmembrane protein 204 Neighboring gene pentraxin 4 Neighboring gene chloride channel, voltage-sensitive 7 Neighboring gene microRNA 12188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The effects of Tel2 on cardiomyocyte survival. Yorichika N, et al. Life Sci, 2019 Sep 1. PMID 31323273, Free PMC Article
    2. Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1. Pal M, et al. Structure, 2014 Jun 10. PMID 24794838, Free PMC Article
    3. Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Rao F, et al. Mol Cell, 2014 Apr 10. PMID 24657168, Free PMC Article
    4. Tel2 regulates the stability of PI3K-related protein kinases. Takai H, et al. Cell, 2007 Dec 28. PMID 18160036
    5. CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Horejsí Z, et al. Mol Cell, 2010 Sep 24. PMID 20864032

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulating Tel2 expression increases mTOR-mediated cardiomyocyte survival and targeting Tel2 could be another therapeutic strategy against ischemic heart disease
      Title: The effects of Tel2 on cardiomyocyte survival.
    2. IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program.
      Title: Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.
    3. The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo.
      Title: CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.
    4. Identify Tel2 as a highly conserved regulator of the stability of PI3K-related protein kinases.
      Title: Tel2 regulates the stability of PI3K-related protein kinases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex stabilizing activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' cotranslational protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TTT Hsp90 cochaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TTT Hsp90 cochaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    telomere length regulation protein TEL2 homolog
    Names
    TEL2, telomere maintenance 2, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163661.1 → NP_001157133.1  telomere length regulation protein TEL2 homolog

      See identical proteins and their annotated locations for NP_001157133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK143827, AK146963, BB083455
      Consensus CDS
      CCDS28507.1
      UniProtKB/Swiss-Prot
      Q3U3J5, Q3UID7, Q3UP41, Q8BN03, Q8C1T3, Q91VQ3, Q9DC40
      Related
      ENSMUSP00000110835.3, ENSMUST00000115181.9
      Conserved Domains (1) summary
      pfam10193
      Location:513 → 621
      Telomere_reg-2; Telomere length regulation protein

    2. NM_027880.2 → NP_082156.2  telomere length regulation protein TEL2 homolog

      See identical proteins and their annotated locations for NP_082156.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK004582, AK146963, BB083455, BB844017, BQ560945
      Consensus CDS
      CCDS28507.1
      UniProtKB/Swiss-Prot
      Q3U3J5, Q3UID7, Q3UP41, Q8BN03, Q8C1T3, Q91VQ3, Q9DC40
      Related
      ENSMUSP00000024987.6, ENSMUST00000024987.6
      Conserved Domains (1) summary
      pfam10193
      Location:513 → 621
      Telomere_reg-2; Telomere length regulation protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25318543..25334951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160789.1 → XP_036016682.1  telomere length regulation protein TEL2 homolog isoform X1

      Conserved Domains (1) summary
      pfam10193
      Location:200 → 308
      Telomere_reg-2; Telomere length regulation protein

    2. XM_036160788.1 → XP_036016681.1  telomere length regulation protein TEL2 homolog isoform X1

      Conserved Domains (1) summary
      pfam10193
      Location:200 → 308
      Telomere_reg-2; Telomere length regulation protein

    3. XM_011246618.3 → XP_011244920.1  telomere length regulation protein TEL2 homolog isoform X1

      Conserved Domains (1) summary
      pfam10193
      Location:200 → 308
      Telomere_reg-2; Telomere length regulation protein

    4. XM_011246619.4 → XP_011244921.1  telomere length regulation protein TEL2 homolog isoform X2

    RNA

    1. XR_385366.5 RNA Sequence

    2. XR_004939579.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DC40.2 GenPept UniProtKB/Swiss-Prot:Q9DC40

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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