Map3k13 mitogen-activated protein kinase kinase kinase 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map3k13provided by MGI
Official Full Name: mitogen-activated protein kinase kinase kinase 13provided by MGI
Primary source: MGI:MGI:2444243
See related: Ensembl:ENSMUSG00000033618 AllianceGenome:MGI:2444243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LZK; C130026N12Rik
Summary: Enables protein serine/threonine kinase activator activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of JUN kinase activity; positive regulation of branching morphogenesis of a nerve; and positive regulation of cell projection organization. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in diencephalon lateral wall mantle layer; dorsal grey horn; late tubule; midbrain mantle layer; and ureter. Orthologous to human MAP3K13 (mitogen-activated protein kinase kinase kinase 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 1.4), small intestine adult (RPKM 1.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B1; 16 12.92 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (21643923..21752189)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (21824056..21933439)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord.
Title: A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord.
Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.
Title: Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.
LZK overexpression in astrocytes enhanced astrogliosis and reduced lesion size. Remarkably, in the absence of injury, LZK overexpression alone induced widespread astrogliosis in the CNS and upregulated astrogliosis activators pSTAT3 and SOX9.
Title: Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS.
By gain- and loss-of-function analyses in neuronal cultures, the authors identify LZK as a novel positive regulator of axon growth.
Title: Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.
LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury.
Title: Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.
Scaffold protein POSH, in association with Shroom3 and mixed lineage kinase LZK, relays axon outgrowth inhibition downstream of NogoA and PirB proteins.
Title: POSH is an intracellular signal transducer for the axon outgrowth inhibitor Nogo66.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables IkappaB kinase complex binding	IEA Inferred from Electronic Annotation more info
enables IkappaB kinase complex binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching morphogenesis of a nerve	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase 13

NP_766409.2

EC 2.7.11.25

XP_006522645.1

EC 2.7.11.25

XP_006522646.1

EC 2.7.11.25

XP_006522647.1

EC 2.7.11.25

XP_011244317.1

EC 2.7.11.25

XP_011244318.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172821.3 → NP_766409.2 mitogen-activated protein kinase kinase kinase 13

See identical proteins and their annotated locations for NP_766409.2

Status: VALIDATED

Source sequence(s)

AK047986, AK054039, BB455895, BB549158, BP761466, CX240141, DQ480427

Consensus CDS

CCDS37294.1

UniProtKB/Swiss-Prot

Q1HKZ5, Q8BKN0

Related

ENSMUSP00000047388.7, ENSMUST00000042065.7

Conserved Domains (1) summary

cd14059
Location:173 → 409

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

21643923..21752189

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522583.5 → XP_006522646.1 mitogen-activated protein kinase kinase kinase 13 isoform X1

See identical proteins and their annotated locations for XP_006522646.1

UniProtKB/Swiss-Prot

Q1HKZ5, Q8BKN0

Related

ENSMUSP00000156202.2, ENSMUST00000232240.2

Conserved Domains (1) summary

cd14059
Location:173 → 409

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
XM_006522582.4 → XP_006522645.1 mitogen-activated protein kinase kinase kinase 13 isoform X1

See identical proteins and their annotated locations for XP_006522645.1

UniProtKB/Swiss-Prot

Q1HKZ5, Q8BKN0

Related

ENSMUSP00000156075.2, ENSMUST00000231988.2

Conserved Domains (1) summary

cd14059
Location:173 → 409

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
XM_011246016.2 → XP_011244318.1 mitogen-activated protein kinase kinase kinase 13 isoform X1

See identical proteins and their annotated locations for XP_011244318.1

UniProtKB/Swiss-Prot

Q1HKZ5, Q8BKN0

Conserved Domains (1) summary

cd14059
Location:173 → 409

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
XM_011246015.3 → XP_011244317.1 mitogen-activated protein kinase kinase kinase 13 isoform X1

See identical proteins and their annotated locations for XP_011244317.1

UniProtKB/Swiss-Prot

Q1HKZ5, Q8BKN0

Conserved Domains (1) summary

cd14059
Location:173 → 409

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
XM_006522584.4 → XP_006522647.1 mitogen-activated protein kinase kinase kinase 13 isoform X1

See identical proteins and their annotated locations for XP_006522647.1

UniProtKB/Swiss-Prot

Q1HKZ5, Q8BKN0

Conserved Domains (1) summary

cd14059
Location:173 → 409

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13