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    Snx31 sorting nexin 31 [ Mus musculus (house mouse) ]

    Gene ID: 66696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx31provided by MGI
    Official Full Name
    sorting nexin 31provided by MGI
    Primary source
    MGI:MGI:1913946
    See related
    Ensembl:ENSMUSG00000013611 AllianceGenome:MGI:1913946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4631426E05Rik
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Part of protein-containing complex. Is expressed in alimentary system; autopod; epidermis; sensory organ; and urinary system. Orthologous to human SNX31 (sorting nexin 31). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward bladder adult (RPKM 80.8) See more
    Orthologs
    human all
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    Genomic context

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    See Snx31 in Genome Data Viewer
    Location:
    15 B3.1; 15 14.48 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (36504208..36560274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36504062..36560129, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:36390760-36390961 Neighboring gene predicted gene, 34316 Neighboring gene STARR-seq mESC enhancer starr_38360 Neighboring gene ankyrin repeat domain 46 Neighboring gene STARR-seq mESC enhancer starr_38361 Neighboring gene STARR-seq mESC enhancer starr_38364 Neighboring gene poly(A) binding protein, cytoplasmic 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An SNX31 variant underlies dominant familial exudative vitreoretinopathy-like pathogenesis. Xu N, et al. JCI Insight, 2023 May 22. PMID 37053012, Free PMC Article
    2. SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells. Vieira N, et al. PLoS One, 2014. PMID 24914955, Free PMC Article
    3. The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. Yu Z, et al. EMBO J, 2009 Jul 8. PMID 19494835, Free PMC Article
    4. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An SNX31 variant underlies dominant familial exudative vitreoretinopathy-like pathogenesis.
      Title: An SNX31 variant underlies dominant familial exudative vitreoretinopathy-like pathogenesis.
    2. These data support a model in which SNX31 mediates the endocytic degradation of uroplakins.
      Title: SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sorting nexin-31

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347022.2 → NP_001333951.1  sorting nexin-31 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC137871
      Consensus CDS
      CCDS84166.1
      UniProtKB/Swiss-Prot
      Q6P8Y7, Q8BH14, Q9D690
      Related
      ENSMUSP00000124063.2, ENSMUST00000161202.8

    2. NM_025712.5 → NP_079988.3  sorting nexin-31 isoform 1

      See identical proteins and their annotated locations for NP_079988.3

      Status: VALIDATED

      Source sequence(s)
      AC137871
      Consensus CDS
      CCDS27430.1
      UniProtKB/Swiss-Prot
      Q6P8Y7
      Related
      ENSMUSP00000013755.6, ENSMUST00000013755.12
      Conserved Domains (3) summary
      cd06885
      Location:4 → 106
      PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
      cl00155
      Location:116 → 204
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:270 → 384
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      36504208..36560274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316727.2 → XP_017172216.1  sorting nexin-31 isoform X3

      Conserved Domains (3) summary
      cl02563
      Location:1 → 40
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl17171
      Location:204 → 318
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:53 → 143
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_006520147.2 → XP_006520210.1  sorting nexin-31 isoform X2

      Conserved Domains (3) summary
      cd06885
      Location:4 → 106
      PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
      cl17171
      Location:270 → 384
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:119 → 209
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_017316726.2 → XP_017172215.1  sorting nexin-31 isoform X1

      Conserved Domains (3) summary
      cd06885
      Location:4 → 106
      PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
      cl17171
      Location:270 → 384
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:119 → 209
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P8Y7.1 GenPept UniProtKB/Swiss-Prot:Q6P8Y7

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