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    Eml5 echinoderm microtubule associated protein like 5 [ Mus musculus (house mouse) ]

    Gene ID: 319670, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eml5provided by MGI
    Official Full Name
    echinoderm microtubule associated protein like 5provided by MGI
    Primary source
    MGI:MGI:2442513
    See related
    Ensembl:ENSMUSG00000051166 AllianceGenome:MGI:2442513
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C130068M19Rik
    Summary
    Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Orthologous to human EML5 (EMAP like 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 12.3), cerebellum adult (RPKM 9.9) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eml5 in Genome Data Viewer
    Location:
    12 E; 12 49.88 cM
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (98752863..98867770, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (98786604..98901511, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 7 Neighboring gene STARR-seq mESC enhancer starr_33000 Neighboring gene protein tyrosine phosphatase, non-receptor type 21 Neighboring gene STARR-positive B cell enhancer ABC_E9861 Neighboring gene zinc finger CCCH type containing 14 Neighboring gene predicted gene, 35463 Neighboring gene STARR-seq mESC enhancer starr_33001 Neighboring gene STARR-seq mESC enhancer starr_33002 Neighboring gene STARR-positive B cell enhancer ABC_E5348 Neighboring gene tetratricopeptide repeat domain 8 Neighboring gene STARR-seq mESC enhancer starr_33003 Neighboring gene predicted gene, 40554 Neighboring gene ribosomal protein L30, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Schilling K, et al. Cerebellum, 2009 Dec. PMID 19554387
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    echinoderm microtubule-associated protein-like 5
    Names
    EMAP-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081191.1 → NP_001074660.1  echinoderm microtubule-associated protein-like 5

      See identical proteins and their annotated locations for NP_001074660.1

      Status: PROVISIONAL

      Source sequence(s)
      AC159193
      Consensus CDS
      CCDS36519.1
      UniProtKB/Swiss-Prot
      Q8BQM8, Q8BRL0, Q8R2W0
      UniProtKB/TrEMBL
      B2RY88
      Related
      ENSMUSP00000152709.2, ENSMUST00000223282.2
      Conserved Domains (4) summary
      COG2319
      Location:353 → 845
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      98752863..98867770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515972.4 → XP_006516035.1  echinoderm microtubule-associated protein-like 5 isoform X3

      UniProtKB/TrEMBL
      B2RY88
      Conserved Domains (4) summary
      COG2319
      Location:1387 → 1806
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      cl29593
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006515970.4 → XP_006516033.1  echinoderm microtubule-associated protein-like 5 isoform X1

      UniProtKB/TrEMBL
      B2RY88
      Conserved Domains (4) summary
      COG2319
      Location:1392 → 1811
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      cl29593
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_036157493.1 → XP_036013386.1  echinoderm microtubule-associated protein-like 5 isoform X4

      UniProtKB/TrEMBL
      B2RY88
      Conserved Domains (4) summary
      COG2319
      Location:1461 → 1867
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      cl29593
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_017315105.2 → XP_017170594.1  echinoderm microtubule-associated protein-like 5 isoform X2

      UniProtKB/TrEMBL
      B2RY88
      Conserved Domains (4) summary
      COG2319
      Location:1395 → 1806
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      cl29593
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_030246770.1 → XP_030102630.1  echinoderm microtubule-associated protein-like 5 isoform X5

      UniProtKB/TrEMBL
      B2RY88
      Conserved Domains (4) summary
      COG2319
      Location:1153 → 1572
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:45 → 80
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:431 → 472
      HELP; HELP motif
      cl29593
      Location:483 → 821
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_006515976.2 → XP_006516039.1  echinoderm microtubule-associated protein-like 5 isoform X8

      Conserved Domains (4) summary
      COG2319
      Location:572 → 991
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:882 → 920
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:516 → 586
      HELP; HELP motif
      cl29593
      Location:72 → 317
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_017315107.2 → XP_017170596.1  echinoderm microtubule-associated protein-like 5 isoform X6

      Conserved Domains (3) summary
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      cl29593
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_030246771.1 → XP_030102631.1  echinoderm microtubule-associated protein-like 5 isoform X7

      Conserved Domains (3) summary
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      cl29593
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_004937514.1 RNA Sequence

    2. XR_004937513.1 RNA Sequence

    3. XR_001780456.2 RNA Sequence

    4. XR_004937508.1 RNA Sequence

    5. XR_001780453.2 RNA Sequence

    6. XR_003950056.1 RNA Sequence

    7. XR_004937516.1 RNA Sequence

    8. XR_004937510.1 RNA Sequence

    9. XR_004937509.1 RNA Sequence

    10. XR_003950058.1 RNA Sequence

    11. XR_004937512.1 RNA Sequence

    12. XR_004937511.1 RNA Sequence

    13. XR_001780457.2 RNA Sequence

    14. XR_001780455.2 RNA Sequence

    15. XR_003950059.2 RNA Sequence

    16. XR_004937515.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQM8.2 GenPept UniProtKB/Swiss-Prot:Q8BQM8

    Gene LinkOut

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