Kif1c kinesin family member 1C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif1cprovided by MGI
Official Full Name: kinesin family member 1Cprovided by MGI
Primary source: MGI:MGI:1098260
See related: Ensembl:ENSMUSG00000020821 AllianceGenome:MGI:1098260
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ltxs1; Orch3; D11Bwg1349e; B430105J22Rik
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi apparatus. Is expressed in alimentary system; hindbrain meninges; submandibular gland primordium; telencephalon; and vibrissa. Human ortholog(s) of this gene implicated in spastic ataxia 2. Orthologous to human KIF1C (kinesin family member 1C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 50.0), colon adult (RPKM 41.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 43.21 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70591170..70622796)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70700396..70731970)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas.
Title: Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas.
Study shows that the microtubule binding surface of Kif1c motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells.
Title: PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
The melanocore-interacting Kif1c-tail (M-INK) probe localize melanosomes in keratinocytes.
Title: M-INK, a novel tool for visualizing melanosomes and melanocores.
by utilizing a forward genetic approach, we identified kinesin family member 1C (Kif1c) as a positional candidate for Orch3 and, using a transgenic approach, demonstrated that Kif1c is Orch3
Title: Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C.
Kif1c was excluded as a candidate anthrax susceptibility gene
Title: Exclusion of Kif1c as a candidate gene for anthrax toxin susceptibility.
More than 90% of early endocytic vesicles associated with Kifc1 also contained Kif5B, and inhibition of Kifc1 with antibody resulted in enhancement of plus-end-directed motility.
Title: Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver.

Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description	Tests
autoimmune orchitis resistance 3 GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

QTL (4) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125046 (e-PCR)
- UniSTS:161868

NoName (e-PCR)
- UniSTS:224387

D11Bwg1349e (e-PCR), detects polymorphism
- UniSTS:141726

Kif1c (e-PCR), detects polymorphism
- UniSTS:525251

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anterograde neuronal dense core vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in retrograde neuronal dense core vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde neuronal dense core vesicle transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein KIF1C

Names: N-3 kinsin; kinesin 1C; kinesin superfamily protein 1C; lethal factor toxin susceptibility 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153103.2 → NP_694743.2 kinesin-like protein KIF1C

See identical proteins and their annotated locations for NP_694743.2

Status: VALIDATED

Source sequence(s)

AB074017, AK029250, AK046574, AL596117

Consensus CDS

CCDS24965.1

UniProtKB/Swiss-Prot

O35071, Q5SX62

UniProtKB/TrEMBL

Q8VI89

Related

ENSMUSP00000092075.5, ENSMUST00000094499.11

Conserved Domains (3) summary

cd00060
Location:499 → 599

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 355

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam16183
Location:352 → 522

Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

70591170..70622796

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156353.1 → XP_036012246.1 kinesin-like protein KIF1C isoform X1

UniProtKB/TrEMBL

E9Q9B0, Q6A011

Conserved Domains (3) summary

cd00060
Location:499 → 599

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 355

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam16183
Location:352 → 522

Kinesin_assoc; Kinesin-associated
XM_006532321.5 → XP_006532384.1 kinesin-like protein KIF1C isoform X2

See identical proteins and their annotated locations for XP_006532384.1

UniProtKB/Swiss-Prot

O35071, Q5SX62

UniProtKB/TrEMBL

Q8VI89

Related

ENSMUSP00000099614.2, ENSMUST00000102554.8

Conserved Domains (3) summary

cd00060
Location:499 → 599

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 355

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam16183
Location:352 → 522

Kinesin_assoc; Kinesin-associated
XM_036156351.1 → XP_036012244.1 kinesin-like protein KIF1C isoform X1

UniProtKB/TrEMBL

E9Q9B0, Q6A011

Conserved Domains (3) summary

cd00060
Location:499 → 599

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 355

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam16183
Location:352 → 522

Kinesin_assoc; Kinesin-associated
XM_006532323.5 → XP_006532386.1 kinesin-like protein KIF1C isoform X4

Conserved Domains (2) summary

cd01365
Location:4 → 355

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam16183
Location:352 → 522

Kinesin_assoc; Kinesin-associated
XM_036156354.1 → XP_036012247.1 kinesin-like protein KIF1C isoform X1

UniProtKB/TrEMBL

E9Q9B0, Q6A011

Related

ENSMUSP00000072048.6, ENSMUST00000072187.12

Conserved Domains (3) summary

cd00060
Location:499 → 599

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 355

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam16183
Location:352 → 522

Kinesin_assoc; Kinesin-associated
XM_006532322.5 → XP_006532385.1 kinesin-like protein KIF1C isoform X2

See identical proteins and their annotated locations for XP_006532385.1

UniProtKB/Swiss-Prot

O35071, Q5SX62

UniProtKB/TrEMBL

Q8VI89

Conserved Domains (3) summary

cd00060
Location:499 → 599

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 355

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam16183
Location:352 → 522

Kinesin_assoc; Kinesin-associated
XM_036156352.1 → XP_036012245.1 kinesin-like protein KIF1C isoform X1

UniProtKB/TrEMBL

E9Q9B0, Q6A011

Conserved Domains (3) summary

cd00060
Location:499 → 599

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 355

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam16183
Location:352 → 522

Kinesin_assoc; Kinesin-associated
XM_036156355.1 → XP_036012248.1 kinesin-like protein KIF1C isoform X3

Conserved Domains (2) summary

cd00060
Location:14 → 114

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam16183
Location:11 → 37

Kinesin_assoc; Kinesin-associated
XM_036156356.1 → XP_036012249.1 kinesin-like protein KIF1C isoform X5