Dis3l2 DIS3 like 3'-5' exoribonuclease 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dis3l2provided by MGI
Official Full Name: DIS3 like 3'-5' exoribonuclease 2provided by MGI
Primary source: MGI:MGI:2442555
See related: Ensembl:ENSMUSG00000053333 AllianceGenome:MGI:2442555
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930429A22Rik; 8030493P09Rik
Summary: Enables 3'-5'-RNA exonuclease activity; magnesium ion binding activity; and poly(U) RNA binding activity. Involved in miRNA catabolic process and stem cell population maintenance. Located in cytoplasm. Is expressed in several structures, including central nervous system; ganglia; metanephros; molar; and nose. Used to study Perlman syndrome. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 10.6), whole brain E14.5 (RPKM 10.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 43.99 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (86629646..86977819)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (86701924..87050097)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DIS3L2 ribonuclease degrades terminal-uridylated RNA to ensure oocyte maturation and female fertility.
Title: DIS3L2 ribonuclease degrades terminal-uridylated RNA to ensure oocyte maturation and female fertility.
The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis.
Title: The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis.
7SB ribosomal RNA can be oligoadenylated by an unknown enzyme and/or oligouridylated by TUT4/7 and subsequently processed by Dis3l2 and Eri1.
Title: Exonuclease requirements for mammalian ribosomal RNA biogenesis and surveillance.
DIS3L2 loss of function results in transcriptional activation of the Igf2/H19 locus in nephron progenitor cells, most likely by leading to the activation of shared cis-regulatory elements that control these genes.
Title: Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and results in up-regulation of Igf2 in nephron progenitor cells.
Dis3l2-mediated decay is a quality control pathway for noncoding RNAs.
Title: Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs.
DIS3L2 interacts with Ago2 and governs target RNA-directed miRNA degradation.
Title: Identification of factors involved in target RNA-directed microRNA degradation.
structure of mouse Dis3l2 in complex with an oligoU RNA to mimic the uridylated tail of pre-let-7
Title: Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway.
identification of Dis3l2 as the 3'-5' exonuclease responsible for the decay of uridylated pre-let-7 in mouse embryonic stem cells
Title: A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5'-RNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5'-RNA exonuclease activity	TAS Traceable Author Statement more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA nuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables poly(U) RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables poly(U) RNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid separation	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid separation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear-transcribed mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in polyuridylation-dependent mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: DIS3-like exonuclease 2

Names: DIS3 mitotic control homolog-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172157.1 → NP_001165628.1 DIS3-like exonuclease 2 isoform 1

See identical proteins and their annotated locations for NP_001165628.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK031180, BB406146, BB654969, CJ063044

Consensus CDS

CCDS48304.1

UniProtKB/Swiss-Prot

Q8CI75

Related

ENSMUSP00000132673.2, ENSMUST00000168237.8

Conserved Domains (2) summary

COG0557
Location:228 → 824

VacB; Exoribonuclease R [Transcription]

pfam17216
Location:50 → 250

Rrp44_CSD1; Rrp44-like cold shock domain
NM_153530.2 → NP_705758.1 DIS3-like exonuclease 2 isoform 2

See identical proteins and their annotated locations for NP_705758.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC102491, AC120860, AC138595

Consensus CDS

CCDS15124.1

UniProtKB/Swiss-Prot

Q8BMG9, Q8CI75

Related

ENSMUSP00000070506.7, ENSMUST00000065694.8

Conserved Domains (2) summary

COG0557
Location:214 → 810

VacB; Exoribonuclease R [Transcription]

pfam00773
Location:369 → 717

RNB; RNB domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

86629646..86977819

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163094.1 → XP_036018987.1 DIS3-like exonuclease 2 isoform X5

Conserved Domains (1) summary

COG0557
Location:125 → 721

VacB; Exoribonuclease R [Transcription]
XM_030252488.2 → XP_030108348.1 DIS3-like exonuclease 2 isoform X7

Conserved Domains (1) summary

COG0557
Location:7 → 603

VacB; Exoribonuclease R [Transcription]
XM_006529301.5 → XP_006529364.1 DIS3-like exonuclease 2 isoform X7

See identical proteins and their annotated locations for XP_006529364.1

Conserved Domains (1) summary

COG0557
Location:7 → 603

VacB; Exoribonuclease R [Transcription]
XM_030252497.2 → XP_030108357.1 DIS3-like exonuclease 2 isoform X8

Conserved Domains (1) summary

COG0557
Location:7 → 567

VacB; Exoribonuclease R [Transcription]
XM_017319469.3 → XP_017174958.1 DIS3-like exonuclease 2 isoform X3

Conserved Domains (2) summary

COG0557
Location:228 → 746

VacB; Exoribonuclease R [Transcription]

pfam17216
Location:50 → 250

Rrp44_CSD1; Rrp44-like cold shock domain
XM_006529298.4 → XP_006529361.1 DIS3-like exonuclease 2 isoform X2

Conserved Domains (2) summary

COG0557
Location:228 → 788

VacB; Exoribonuclease R [Transcription]

pfam17216
Location:50 → 250

Rrp44_CSD1; Rrp44-like cold shock domain
XM_030252485.2 → XP_030108345.1 DIS3-like exonuclease 2 isoform X7

Conserved Domains (1) summary

COG0557
Location:7 → 603

VacB; Exoribonuclease R [Transcription]
XM_006529300.4 → XP_006529363.1 DIS3-like exonuclease 2 isoform X7

See identical proteins and their annotated locations for XP_006529363.1

Conserved Domains (1) summary

COG0557
Location:7 → 603

VacB; Exoribonuclease R [Transcription]
XM_036163093.1 → XP_036018986.1 DIS3-like exonuclease 2 isoform X4

Conserved Domains (2) summary

COG0557
Location:214 → 732

VacB; Exoribonuclease R [Transcription]

pfam17216
Location:50 → 236

Rrp44_CSD1; Rrp44-like cold shock domain
XM_030252483.2 → XP_030108343.1 DIS3-like exonuclease 2 isoform X1

Conserved Domains (2) summary

COG0557
Location:228 → 824

VacB; Exoribonuclease R [Transcription]

pfam17216
Location:50 → 250

Rrp44_CSD1; Rrp44-like cold shock domain
XM_036163095.1 → XP_036018988.1 DIS3-like exonuclease 2 isoform X6

Conserved Domains (1) summary

COG0557
Location:18 → 614

VacB; Exoribonuclease R [Transcription]